| Full name: RNA polymerase I and III subunit C | Alias Symbol: RPA40|RPA39|RPA5|RPAC1 | ||
| Type: protein-coding gene | Cytoband: 6p21.1 | ||
| Entrez ID: 9533 | HGNC ID: HGNC:20194 | Ensembl Gene: ENSG00000171453 | OMIM ID: 610060 |
| Drug and gene relationship at DGIdb | |||
Expression of POLR1C:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | POLR1C | 9533 | 209317_at | 1.0407 | 0.1173 | |
| GSE20347 | POLR1C | 9533 | 209317_at | 0.5389 | 0.0008 | |
| GSE23400 | POLR1C | 9533 | 207515_s_at | 0.2899 | 0.0000 | |
| GSE26886 | POLR1C | 9533 | 209317_at | 0.1519 | 0.2934 | |
| GSE29001 | POLR1C | 9533 | 209317_at | 0.5477 | 0.0194 | |
| GSE38129 | POLR1C | 9533 | 209317_at | 0.8290 | 0.0000 | |
| GSE45670 | POLR1C | 9533 | 209317_at | 0.4159 | 0.0027 | |
| GSE53622 | POLR1C | 9533 | 58310 | 0.1855 | 0.0080 | |
| GSE53624 | POLR1C | 9533 | 122194 | 0.4628 | 0.0000 | |
| GSE63941 | POLR1C | 9533 | 207515_s_at | 1.0095 | 0.0146 | |
| GSE77861 | POLR1C | 9533 | 209317_at | 0.0758 | 0.8064 | |
| GSE97050 | POLR1C | 9533 | A_23_P70409 | 0.3611 | 0.2261 | |
| SRP007169 | POLR1C | 9533 | RNAseq | 0.5116 | 0.2256 | |
| SRP008496 | POLR1C | 9533 | RNAseq | 0.1297 | 0.6861 | |
| SRP064894 | POLR1C | 9533 | RNAseq | 0.2588 | 0.1793 | |
| SRP133303 | POLR1C | 9533 | RNAseq | 0.2163 | 0.1697 | |
| SRP159526 | POLR1C | 9533 | RNAseq | 0.3273 | 0.1377 | |
| SRP193095 | POLR1C | 9533 | RNAseq | 0.1461 | 0.1836 | |
| SRP219564 | POLR1C | 9533 | RNAseq | 0.4597 | 0.2486 | |
| TCGA | POLR1C | 9533 | RNAseq | 0.1787 | 0.0064 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by POLR1C expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of POLR1C:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | POLR1C | 9533 | 7 | 0 | 23 | |
| GSE20123 | POLR1C | 9533 | 7 | 0 | 23 | |
| GSE43470 | POLR1C | 9533 | 6 | 0 | 37 | |
| GSE46452 | POLR1C | 9533 | 2 | 9 | 48 | |
| GSE47630 | POLR1C | 9533 | 8 | 4 | 28 | |
| GSE54993 | POLR1C | 9533 | 3 | 2 | 65 | |
| GSE54994 | POLR1C | 9533 | 11 | 4 | 38 | |
| GSE60625 | POLR1C | 9533 | 0 | 1 | 10 | |
| GSE74703 | POLR1C | 9533 | 6 | 0 | 30 | |
| GSE74704 | POLR1C | 9533 | 3 | 0 | 17 | |
| TCGA | POLR1C | 9533 | 20 | 12 | 64 |
Total number of gains: 73; Total number of losses: 32; Total Number of normals: 383.
Somatic mutations of POLR1C:
Generating mutation plots.
Highly correlated genes for POLR1C:
Showing top 20/1314 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| POLR1C | NACC1 | 0.785601 | 3 | 0 | 3 |
| POLR1C | PNKP | 0.754327 | 3 | 0 | 3 |
| POLR1C | ZNF518B | 0.753285 | 3 | 0 | 3 |
| POLR1C | STRN4 | 0.74538 | 3 | 0 | 3 |
| POLR1C | ALG1 | 0.74358 | 3 | 0 | 3 |
| POLR1C | SFR1 | 0.742137 | 3 | 0 | 3 |
| POLR1C | PIF1 | 0.73523 | 3 | 0 | 3 |
| POLR1C | LRRC58 | 0.730707 | 4 | 0 | 3 |
| POLR1C | COMMD2 | 0.728191 | 4 | 0 | 3 |
| POLR1C | ZNF451 | 0.724264 | 4 | 0 | 3 |
| POLR1C | ZNF670 | 0.721455 | 3 | 0 | 3 |
| POLR1C | CCDC85C | 0.71653 | 3 | 0 | 3 |
| POLR1C | PPP1R9B | 0.715523 | 3 | 0 | 3 |
| POLR1C | LRRC34 | 0.714282 | 3 | 0 | 3 |
| POLR1C | SIX4 | 0.708792 | 4 | 0 | 4 |
| POLR1C | MED12 | 0.705689 | 3 | 0 | 3 |
| POLR1C | ISOC2 | 0.704777 | 3 | 0 | 3 |
| POLR1C | PPIL1 | 0.697567 | 8 | 0 | 7 |
| POLR1C | WDR81 | 0.696328 | 3 | 0 | 3 |
| POLR1C | HAS3 | 0.69615 | 3 | 0 | 3 |
For details and further investigation, click here
