| Full name: Rap guanine nucleotide exchange factor 3 | Alias Symbol: cAMP-GEFI|EPAC|bcm910 | ||
| Type: protein-coding gene | Cytoband: 12q13.11 | ||
| Entrez ID: 10411 | HGNC ID: HGNC:16629 | Ensembl Gene: ENSG00000079337 | OMIM ID: 606057 |
| Drug and gene relationship at DGIdb | |||
RAPGEF3 involved pathways:
Expression of RAPGEF3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RAPGEF3 | 10411 | 210051_at | -0.1585 | 0.8727 | |
| GSE20347 | RAPGEF3 | 10411 | 210051_at | -0.4548 | 0.0003 | |
| GSE23400 | RAPGEF3 | 10411 | 215027_at | -0.4212 | 0.0000 | |
| GSE26886 | RAPGEF3 | 10411 | 210051_at | -0.5135 | 0.0045 | |
| GSE29001 | RAPGEF3 | 10411 | 210051_at | -0.2243 | 0.5315 | |
| GSE38129 | RAPGEF3 | 10411 | 210051_at | -0.7301 | 0.0000 | |
| GSE45670 | RAPGEF3 | 10411 | 210051_at | -0.3208 | 0.1009 | |
| GSE53622 | RAPGEF3 | 10411 | 87661 | 0.3101 | 0.0449 | |
| GSE53624 | RAPGEF3 | 10411 | 87661 | 0.0535 | 0.6840 | |
| GSE63941 | RAPGEF3 | 10411 | 210051_at | 0.2478 | 0.5609 | |
| GSE77861 | RAPGEF3 | 10411 | 210051_at | -0.2556 | 0.0376 | |
| GSE97050 | RAPGEF3 | 10411 | A_33_P3389178 | -0.1339 | 0.6146 | |
| SRP007169 | RAPGEF3 | 10411 | RNAseq | -1.3310 | 0.0524 | |
| SRP064894 | RAPGEF3 | 10411 | RNAseq | -0.4037 | 0.1839 | |
| SRP133303 | RAPGEF3 | 10411 | RNAseq | -1.2604 | 0.0000 | |
| SRP159526 | RAPGEF3 | 10411 | RNAseq | -2.1196 | 0.0000 | |
| SRP193095 | RAPGEF3 | 10411 | RNAseq | -0.4056 | 0.0621 | |
| SRP219564 | RAPGEF3 | 10411 | RNAseq | -0.8209 | 0.0021 | |
| TCGA | RAPGEF3 | 10411 | RNAseq | -0.5974 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by RAPGEF3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RAPGEF3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RAPGEF3 | 10411 | 6 | 1 | 23 | |
| GSE20123 | RAPGEF3 | 10411 | 6 | 1 | 23 | |
| GSE43470 | RAPGEF3 | 10411 | 3 | 1 | 39 | |
| GSE46452 | RAPGEF3 | 10411 | 8 | 1 | 50 | |
| GSE47630 | RAPGEF3 | 10411 | 11 | 2 | 27 | |
| GSE54993 | RAPGEF3 | 10411 | 0 | 5 | 65 | |
| GSE54994 | RAPGEF3 | 10411 | 6 | 1 | 46 | |
| GSE60625 | RAPGEF3 | 10411 | 0 | 0 | 11 | |
| GSE74703 | RAPGEF3 | 10411 | 3 | 1 | 32 | |
| GSE74704 | RAPGEF3 | 10411 | 4 | 1 | 15 | |
| TCGA | RAPGEF3 | 10411 | 16 | 12 | 68 |
Total number of gains: 63; Total number of losses: 26; Total Number of normals: 399.
Somatic mutations of RAPGEF3:
Generating mutation plots.
Highly correlated genes for RAPGEF3:
Showing top 20/832 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RAPGEF3 | LINC00930 | 0.901416 | 3 | 0 | 3 |
| RAPGEF3 | KRTAP10-3 | 0.78454 | 3 | 0 | 3 |
| RAPGEF3 | ZSCAN30 | 0.780201 | 3 | 0 | 3 |
| RAPGEF3 | USP2-AS1 | 0.778864 | 3 | 0 | 3 |
| RAPGEF3 | TCF23 | 0.773642 | 3 | 0 | 3 |
| RAPGEF3 | LINC01281 | 0.773308 | 3 | 0 | 3 |
| RAPGEF3 | SEZ6 | 0.752512 | 4 | 0 | 4 |
| RAPGEF3 | LINC00924 | 0.744303 | 3 | 0 | 3 |
| RAPGEF3 | HCG18 | 0.730746 | 4 | 0 | 3 |
| RAPGEF3 | KRTAP4-8 | 0.725466 | 3 | 0 | 3 |
| RAPGEF3 | C5orf17 | 0.72325 | 3 | 0 | 3 |
| RAPGEF3 | C20orf85 | 0.719131 | 3 | 0 | 3 |
| RAPGEF3 | FAM205A | 0.710834 | 3 | 0 | 3 |
| RAPGEF3 | LINC00632 | 0.709077 | 3 | 0 | 3 |
| RAPGEF3 | TIAM1 | 0.707135 | 4 | 0 | 4 |
| RAPGEF3 | EP300-AS1 | 0.706399 | 4 | 0 | 4 |
| RAPGEF3 | LINC00917 | 0.706216 | 3 | 0 | 3 |
| RAPGEF3 | RSPH9 | 0.703977 | 3 | 0 | 3 |
| RAPGEF3 | MIOX | 0.702303 | 3 | 0 | 3 |
| RAPGEF3 | GNRH2 | 0.701389 | 7 | 0 | 7 |
For details and further investigation, click here
