TIAM1

 

Full name: T cell lymphoma invasion and metastasis 1 Alias Symbol: 
Type: protein-coding gene Cytoband: 21q22.11
Entrez ID: 7074 HGNC ID: HGNC:11805 Ensembl Gene: ENSG00000156299 OMIM ID: 600687
Drug and gene relationship at DGIdb

 

TIAM1 involved pathways:

KEGG pathway Description View
hsa04014Ras signaling pathway
hsa04015Rap1 signaling pathway
hsa04024cAMP signaling pathway
hsa04062Chemokine signaling pathway
hsa04810Regulation of actin cytoskeleton
hsa05205Proteoglycans in cancer

 

Expression of TIAM1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 TIAM1 7074 213135_at -0.7375 0.3760
GSE20347 TIAM1 7074 213135_at -1.7246 0.0000
GSE23400 TIAM1 7074 213135_at -1.4795 0.0000
GSE26886 TIAM1 7074 213135_at -1.7910 0.0000
GSE29001 TIAM1 7074 213135_at -1.5058 0.0024
GSE38129 TIAM1 7074 213135_at -1.1267 0.0007
GSE45670 TIAM1 7074 213135_at -0.3468 0.1127
GSE53622 TIAM1 7074 79753 -1.5729 0.0000
GSE53624 TIAM1 7074 79753 -1.6920 0.0000
GSE63941 TIAM1 7074 213135_at 2.9058 0.0014
GSE77861 TIAM1 7074 213135_at -1.5058 0.0096
GSE97050 TIAM1 7074 A_33_P3381751 -0.8715 0.2417
SRP007169 TIAM1 7074 RNAseq -1.4246 0.0002
SRP008496 TIAM1 7074 RNAseq -1.5613 0.0000
SRP064894 TIAM1 7074 RNAseq -1.3132 0.0000
SRP133303 TIAM1 7074 RNAseq -1.8577 0.0000
SRP159526 TIAM1 7074 RNAseq -1.9753 0.0000
SRP193095 TIAM1 7074 RNAseq -1.6884 0.0000
SRP219564 TIAM1 7074 RNAseq -2.3299 0.0011
TCGA TIAM1 7074 RNAseq 0.3300 0.0051

Upregulated datasets: 1; Downregulated datasets: 15.  

 

Survival by TIAM1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of TIAM1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 TIAM1 7074 3 10 17
GSE20123 TIAM1 7074 3 10 17
GSE43470 TIAM1 7074 2 9 32
GSE46452 TIAM1 7074 1 21 37
GSE47630 TIAM1 7074 6 17 17
GSE54993 TIAM1 7074 9 1 60
GSE54994 TIAM1 7074 1 9 43
GSE60625 TIAM1 7074 0 0 11
GSE74703 TIAM1 7074 2 6 28
GSE74704 TIAM1 7074 2 6 12
TCGA TIAM1 7074 8 38 50

Total number of gains: 37; Total number of losses: 127; Total Number of normals: 324.  

 

Somatic mutations of TIAM1:

 

Generating mutation plots.

 

Highly correlated genes for TIAM1:

 

Showing top 20/1555 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
TIAM1CYSRT10.849083606
TIAM1C6orf1320.844006606
TIAM1VSIG10L0.831787606
TIAM1ARHGAP270.829978808
TIAM1TMEM1540.827362606
TIAM1BLNK0.82443111011
TIAM1EPGN0.824047303
TIAM1RASSF50.820556707
TIAM1SLC16A60.81785511011
TIAM1NIPAL10.81405303
TIAM1MPZL30.811287808
TIAM1ZDHHC130.81083711011
TIAM1SCEL0.81082211011
TIAM1GRPEL20.808674707
TIAM1RAB250.80679412012
TIAM1SCNN1B0.80662310010
TIAM1TMPRSS11E0.80661410010
TIAM1FCHO20.80618707
TIAM1USP6NL0.80576811011
TIAM1GBP60.805665404

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