| Full name: retinoic acid receptor beta | Alias Symbol: HAP|NR1B2|RRB2 | ||
| Type: protein-coding gene | Cytoband: 3p24.2 | ||
| Entrez ID: 5915 | HGNC ID: HGNC:9865 | Ensembl Gene: ENSG00000077092 | OMIM ID: 180220 |
| Drug and gene relationship at DGIdb | |||
RARB involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05200 | Pathways in cancer | |
| hsa05222 | Small cell lung cancer | |
| hsa05223 | Non-small cell lung cancer |
Expression of RARB:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RARB | 5915 | 205080_at | -0.4351 | 0.7027 | |
| GSE20347 | RARB | 5915 | 205080_at | -0.0877 | 0.6617 | |
| GSE23400 | RARB | 5915 | 205080_at | -0.0958 | 0.0634 | |
| GSE26886 | RARB | 5915 | 205080_at | -0.7556 | 0.0253 | |
| GSE29001 | RARB | 5915 | 205080_at | -0.3295 | 0.1479 | |
| GSE38129 | RARB | 5915 | 205080_at | -0.2453 | 0.1284 | |
| GSE45670 | RARB | 5915 | 205080_at | -0.6646 | 0.0764 | |
| GSE53622 | RARB | 5915 | 8392 | -0.3403 | 0.0621 | |
| GSE53624 | RARB | 5915 | 8392 | -0.6649 | 0.0000 | |
| GSE63941 | RARB | 5915 | 205080_at | 0.8075 | 0.5159 | |
| GSE77861 | RARB | 5915 | 205080_at | -0.0707 | 0.8332 | |
| GSE97050 | RARB | 5915 | A_33_P3305749 | -0.8267 | 0.1372 | |
| SRP007169 | RARB | 5915 | RNAseq | -0.7239 | 0.3095 | |
| SRP008496 | RARB | 5915 | RNAseq | 0.8675 | 0.1121 | |
| SRP064894 | RARB | 5915 | RNAseq | 0.0967 | 0.7373 | |
| SRP133303 | RARB | 5915 | RNAseq | -0.1312 | 0.6501 | |
| SRP159526 | RARB | 5915 | RNAseq | -0.0796 | 0.8450 | |
| SRP193095 | RARB | 5915 | RNAseq | 0.1164 | 0.6237 | |
| SRP219564 | RARB | 5915 | RNAseq | -0.0242 | 0.9782 | |
| TCGA | RARB | 5915 | RNAseq | -0.0289 | 0.8832 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by RARB expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RARB:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RARB | 5915 | 0 | 18 | 12 | |
| GSE20123 | RARB | 5915 | 0 | 18 | 12 | |
| GSE43470 | RARB | 5915 | 0 | 20 | 23 | |
| GSE46452 | RARB | 5915 | 2 | 17 | 40 | |
| GSE47630 | RARB | 5915 | 1 | 24 | 15 | |
| GSE54993 | RARB | 5915 | 6 | 2 | 62 | |
| GSE54994 | RARB | 5915 | 1 | 32 | 20 | |
| GSE60625 | RARB | 5915 | 5 | 0 | 6 | |
| GSE74703 | RARB | 5915 | 0 | 17 | 19 | |
| GSE74704 | RARB | 5915 | 0 | 12 | 8 | |
| TCGA | RARB | 5915 | 1 | 71 | 24 |
Total number of gains: 16; Total number of losses: 231; Total Number of normals: 241.
Somatic mutations of RARB:
Generating mutation plots.
Highly correlated genes for RARB:
Showing top 20/325 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RARB | WEE1 | 0.769392 | 3 | 0 | 3 |
| RARB | ZNF844 | 0.731525 | 3 | 0 | 3 |
| RARB | RFX5 | 0.730429 | 3 | 0 | 3 |
| RARB | WDR13 | 0.729594 | 3 | 0 | 3 |
| RARB | ICA1L | 0.725298 | 4 | 0 | 3 |
| RARB | PARD3B | 0.723487 | 4 | 0 | 4 |
| RARB | MAT2B | 0.720293 | 3 | 0 | 3 |
| RARB | SAP30L | 0.718494 | 3 | 0 | 3 |
| RARB | ATXN7L3B | 0.707624 | 3 | 0 | 3 |
| RARB | ZNF548 | 0.694245 | 3 | 0 | 3 |
| RARB | TRAPPC2 | 0.690164 | 3 | 0 | 3 |
| RARB | TRAPPC8 | 0.689568 | 3 | 0 | 3 |
| RARB | COX10 | 0.688773 | 3 | 0 | 3 |
| RARB | TSPAN3 | 0.686496 | 3 | 0 | 3 |
| RARB | SLC25A3 | 0.682608 | 4 | 0 | 3 |
| RARB | TNFRSF19 | 0.682212 | 3 | 0 | 3 |
| RARB | NDUFS3 | 0.679838 | 3 | 0 | 3 |
| RARB | NHSL2 | 0.678026 | 3 | 0 | 3 |
| RARB | RABL3 | 0.675803 | 4 | 0 | 3 |
| RARB | ARAF | 0.670665 | 3 | 0 | 3 |
For details and further investigation, click here
