RFX5

 

Full name: regulatory factor X5 Alias Symbol: 
Type: protein-coding gene Cytoband: 1q21.3
Entrez ID: 5993 HGNC ID: HGNC:9986 Ensembl Gene: ENSG00000143390 OMIM ID: 601863
Drug and gene relationship at DGIdb

 

RFX5 involved pathways:

KEGG pathway Description View
hsa04612Antigen processing and presentation
hsa05152Tuberculosis

 

Expression of RFX5:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 RFX5 5993 202963_at 0.2142 0.6305
GSE20347 RFX5 5993 202963_at 0.4682 0.0049
GSE23400 RFX5 5993 202964_s_at 0.1629 0.0005
GSE26886 RFX5 5993 202963_at 0.6656 0.0208
GSE29001 RFX5 5993 202963_at 0.8184 0.0144
GSE38129 RFX5 5993 202963_at 0.3116 0.0293
GSE45670 RFX5 5993 202963_at 0.1091 0.5965
GSE53622 RFX5 5993 155074 0.3184 0.0018
GSE53624 RFX5 5993 155074 0.3001 0.0034
GSE63941 RFX5 5993 202963_at 0.2427 0.6519
GSE77861 RFX5 5993 202963_at 0.2747 0.4475
GSE97050 RFX5 5993 A_24_P20032 -0.0707 0.7538
SRP007169 RFX5 5993 RNAseq 0.5953 0.1222
SRP008496 RFX5 5993 RNAseq 0.8075 0.0030
SRP064894 RFX5 5993 RNAseq 0.1368 0.3373
SRP133303 RFX5 5993 RNAseq 0.0228 0.9114
SRP159526 RFX5 5993 RNAseq 0.0830 0.6618
SRP193095 RFX5 5993 RNAseq 0.2486 0.0181
SRP219564 RFX5 5993 RNAseq -0.1181 0.7639
TCGA RFX5 5993 RNAseq 0.1199 0.0238

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by RFX5 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of RFX5:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 RFX5 5993 14 0 16
GSE20123 RFX5 5993 14 0 16
GSE43470 RFX5 5993 6 1 36
GSE46452 RFX5 5993 2 1 56
GSE47630 RFX5 5993 14 0 26
GSE54993 RFX5 5993 0 4 66
GSE54994 RFX5 5993 15 0 38
GSE60625 RFX5 5993 0 0 11
GSE74703 RFX5 5993 6 1 29
GSE74704 RFX5 5993 7 0 13
TCGA RFX5 5993 37 2 57

Total number of gains: 115; Total number of losses: 9; Total Number of normals: 364.  

 

Somatic mutations of RFX5:

 

Generating mutation plots.

 

Highly correlated genes for RFX5:

 

Showing top 20/727 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
RFX5B3GALNT20.819202303
RFX5TEX2610.796474303
RFX5COMMD70.784808303
RFX5METAP1D0.779835303
RFX5LRRC580.75904303
RFX5C15orf610.751482303
RFX5SLC25A330.749431404
RFX5DLG50.746931303
RFX5ZNF320.741207403
RFX5MX10.740837303
RFX5FBXO60.739993303
RFX5YBEY0.733624303
RFX5SBNO10.733578404
RFX5RARB0.730429303
RFX5VPS26B0.728683303
RFX5ACP60.728121303
RFX5LRRC340.725463303
RFX5DEXI0.725326303
RFX5ASB70.724845303
RFX5USP340.716106303

For details and further investigation, click here