ARAF

 

Full name: A-Raf proto-oncogene, serine/threonine kinase Alias Symbol: 
Type: protein-coding gene Cytoband: Xp11.3
Entrez ID: 369 HGNC ID: HGNC:646 Ensembl Gene: ENSG00000078061 OMIM ID: 311010
Drug and gene relationship at DGIdb
Screen Evidence:
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

ARAF involved pathways:

KEGG pathway Description View
hsa04012ErbB signaling pathway
hsa04068FoxO signaling pathway
hsa04270Vascular smooth muscle contraction
hsa04650Natural killer cell mediated cytotoxicity
hsa04720Long-term potentiation
hsa04726Serotonergic synapse
hsa04730Long-term depression
hsa04810Regulation of actin cytoskeleton
hsa04910Insulin signaling pathway
hsa04914Progesterone-mediated oocyte maturation
hsa05034Alcoholism
hsa05160Hepatitis C
hsa05200Pathways in cancer
hsa05205Proteoglycans in cancer
hsa05210Colorectal cancer
hsa05211Renal cell carcinoma
hsa05212Pancreatic cancer
hsa05213Endometrial cancer
hsa05214Glioma
hsa05215Prostate cancer
hsa05218Melanoma
hsa05219Bladder cancer
hsa05220Chronic myeloid leukemia
hsa05221Acute myeloid leukemia
hsa05223Non-small cell lung cancer

 

Expression of ARAF:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 ARAF 369 201895_at 0.0429 0.9518
GSE20347 ARAF 369 201895_at -0.1697 0.1825
GSE23400 ARAF 369 201895_at -0.0101 0.8443
GSE26886 ARAF 369 201895_at -0.1047 0.5430
GSE29001 ARAF 369 201895_at -0.2721 0.1550
GSE38129 ARAF 369 201895_at -0.1645 0.3130
GSE45670 ARAF 369 201895_at 0.2484 0.1710
GSE53622 ARAF 369 43354 -0.0256 0.7236
GSE53624 ARAF 369 111765 0.0223 0.7717
GSE63941 ARAF 369 201895_at 0.7513 0.0229
GSE77861 ARAF 369 201895_at -0.0398 0.8065
GSE97050 ARAF 369 A_23_P73511 0.1949 0.5507
SRP007169 ARAF 369 RNAseq 0.3006 0.4957
SRP008496 ARAF 369 RNAseq 0.3994 0.1546
SRP064894 ARAF 369 RNAseq 0.3142 0.1673
SRP133303 ARAF 369 RNAseq 0.0985 0.6605
SRP159526 ARAF 369 RNAseq 0.1058 0.6438
SRP193095 ARAF 369 RNAseq -0.0119 0.9088
SRP219564 ARAF 369 RNAseq 0.2164 0.3978
TCGA ARAF 369 RNAseq -0.1930 0.0000

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by ARAF expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of ARAF:

 

No record found for this gene.

 

Somatic mutations of ARAF:

 

Generating mutation plots.

 

Highly correlated genes for ARAF:

 

Showing top 20/306 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
ARAFZBTB220.764553404
ARAFAP1B10.764135303
ARAFNUDT160.749894303
ARAFTMEM2050.745939303
ARAFZNF8620.740983303
ARAFECSIT0.738734303
ARAFGANAB0.73755303
ARAFTEX2610.733763303
ARAFEEFSEC0.728931504
ARAFZNF4670.723374303
ARAFTMEM530.722095303
ARAFMAP1S0.721284303
ARAFMAST10.720756403
ARAFSNAPC40.718781303
ARAFMED250.716699303
ARAFRNF1250.713296303
ARAFCCDC240.707435303
ARAFRAPGEF10.705348303
ARAFKDM4B0.704906303
ARAFATAT10.704048303

For details and further investigation, click here