| Full name: cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 17p12 | ||
| Entrez ID: 1352 | HGNC ID: HGNC:2260 | Ensembl Gene: ENSG00000006695 | OMIM ID: 602125 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of COX10:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | COX10 | 1352 | 203858_s_at | -0.1452 | 0.6833 | |
| GSE20347 | COX10 | 1352 | 203858_s_at | -0.0761 | 0.4143 | |
| GSE23400 | COX10 | 1352 | 203858_s_at | -0.0247 | 0.5624 | |
| GSE26886 | COX10 | 1352 | 203858_s_at | -0.3956 | 0.0344 | |
| GSE29001 | COX10 | 1352 | 203858_s_at | -0.0540 | 0.7385 | |
| GSE38129 | COX10 | 1352 | 203858_s_at | -0.1286 | 0.1072 | |
| GSE45670 | COX10 | 1352 | 203858_s_at | 0.1566 | 0.1975 | |
| GSE53622 | COX10 | 1352 | 13637 | -0.0395 | 0.7365 | |
| GSE53624 | COX10 | 1352 | 13637 | 0.1311 | 0.3167 | |
| GSE63941 | COX10 | 1352 | 203858_s_at | 1.1312 | 0.0218 | |
| GSE77861 | COX10 | 1352 | 203858_s_at | -0.0414 | 0.8756 | |
| GSE97050 | COX10 | 1352 | A_23_P55123 | -0.3492 | 0.5008 | |
| SRP007169 | COX10 | 1352 | RNAseq | -0.0618 | 0.8974 | |
| SRP008496 | COX10 | 1352 | RNAseq | -0.4649 | 0.1175 | |
| SRP064894 | COX10 | 1352 | RNAseq | 0.3757 | 0.0380 | |
| SRP133303 | COX10 | 1352 | RNAseq | -0.0058 | 0.9677 | |
| SRP159526 | COX10 | 1352 | RNAseq | -0.1449 | 0.6692 | |
| SRP193095 | COX10 | 1352 | RNAseq | -0.0686 | 0.4893 | |
| SRP219564 | COX10 | 1352 | RNAseq | 0.3723 | 0.3666 | |
| TCGA | COX10 | 1352 | RNAseq | -0.0745 | 0.1850 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by COX10 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of COX10:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | COX10 | 1352 | 3 | 3 | 24 | |
| GSE20123 | COX10 | 1352 | 3 | 3 | 24 | |
| GSE43470 | COX10 | 1352 | 2 | 5 | 36 | |
| GSE46452 | COX10 | 1352 | 34 | 1 | 24 | |
| GSE47630 | COX10 | 1352 | 7 | 1 | 32 | |
| GSE54993 | COX10 | 1352 | 3 | 2 | 65 | |
| GSE54994 | COX10 | 1352 | 6 | 6 | 41 | |
| GSE60625 | COX10 | 1352 | 4 | 0 | 7 | |
| GSE74703 | COX10 | 1352 | 2 | 4 | 30 | |
| GSE74704 | COX10 | 1352 | 2 | 2 | 16 | |
| TCGA | COX10 | 1352 | 17 | 23 | 56 |
Total number of gains: 83; Total number of losses: 50; Total Number of normals: 355.
Somatic mutations of COX10:
Generating mutation plots.
Highly correlated genes for COX10:
Showing top 20/274 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| COX10 | VPS26A | 0.756611 | 3 | 0 | 3 |
| COX10 | NSMCE1 | 0.73198 | 3 | 0 | 3 |
| COX10 | TCHP | 0.723835 | 3 | 0 | 3 |
| COX10 | PDE6D | 0.719725 | 3 | 0 | 3 |
| COX10 | EIF3F | 0.714 | 3 | 0 | 3 |
| COX10 | PRPF38A | 0.709712 | 4 | 0 | 4 |
| COX10 | ATRIP | 0.706128 | 3 | 0 | 3 |
| COX10 | CHCHD3 | 0.705018 | 3 | 0 | 3 |
| COX10 | C21orf91 | 0.696954 | 3 | 0 | 3 |
| COX10 | PLEKHJ1 | 0.691464 | 3 | 0 | 3 |
| COX10 | USP54 | 0.690608 | 3 | 0 | 3 |
| COX10 | RARB | 0.688773 | 3 | 0 | 3 |
| COX10 | EIF2B2 | 0.684406 | 3 | 0 | 3 |
| COX10 | KTI12 | 0.669682 | 3 | 0 | 3 |
| COX10 | ELAVL1 | 0.667071 | 3 | 0 | 3 |
| COX10 | FGD6 | 0.666803 | 3 | 0 | 3 |
| COX10 | ACSS3 | 0.665062 | 4 | 0 | 3 |
| COX10 | BABAM1 | 0.664929 | 5 | 0 | 5 |
| COX10 | SPCS1 | 0.662779 | 3 | 0 | 3 |
| COX10 | GDPD1 | 0.662632 | 4 | 0 | 3 |
For details and further investigation, click here
