| Full name: WEE1 G2 checkpoint kinase | Alias Symbol: WEE1A | ||
| Type: protein-coding gene | Cytoband: 11p15.4 | ||
| Entrez ID: 7465 | HGNC ID: HGNC:12761 | Ensembl Gene: ENSG00000166483 | OMIM ID: 193525 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
WEE1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04110 | Cell cycle |
Expression of WEE1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | WEE1 | 7465 | 212533_at | -0.3332 | 0.6659 | |
| GSE20347 | WEE1 | 7465 | 212533_at | -0.6742 | 0.0109 | |
| GSE23400 | WEE1 | 7465 | 212533_at | -0.5364 | 0.0000 | |
| GSE26886 | WEE1 | 7465 | 212533_at | -0.2759 | 0.0847 | |
| GSE29001 | WEE1 | 7465 | 212533_at | -0.5544 | 0.0063 | |
| GSE38129 | WEE1 | 7465 | 212533_at | -0.3613 | 0.1298 | |
| GSE45670 | WEE1 | 7465 | 212533_at | -0.4239 | 0.0308 | |
| GSE53622 | WEE1 | 7465 | 5471 | -0.7576 | 0.0000 | |
| GSE53624 | WEE1 | 7465 | 5471 | -0.7131 | 0.0000 | |
| GSE63941 | WEE1 | 7465 | 212533_at | 0.1283 | 0.7611 | |
| GSE77861 | WEE1 | 7465 | 212533_at | 0.3430 | 0.5390 | |
| GSE97050 | WEE1 | 7465 | A_33_P3290567 | -0.3710 | 0.2569 | |
| SRP007169 | WEE1 | 7465 | RNAseq | -1.0636 | 0.0111 | |
| SRP008496 | WEE1 | 7465 | RNAseq | -0.7218 | 0.0441 | |
| SRP064894 | WEE1 | 7465 | RNAseq | -1.0508 | 0.0001 | |
| SRP133303 | WEE1 | 7465 | RNAseq | -0.4573 | 0.1001 | |
| SRP159526 | WEE1 | 7465 | RNAseq | -0.4397 | 0.1144 | |
| SRP193095 | WEE1 | 7465 | RNAseq | -0.0318 | 0.9022 | |
| SRP219564 | WEE1 | 7465 | RNAseq | -0.1059 | 0.7195 | |
| TCGA | WEE1 | 7465 | RNAseq | -0.0397 | 0.4885 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by WEE1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of WEE1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | WEE1 | 7465 | 0 | 9 | 21 | |
| GSE20123 | WEE1 | 7465 | 0 | 9 | 21 | |
| GSE43470 | WEE1 | 7465 | 1 | 6 | 36 | |
| GSE46452 | WEE1 | 7465 | 7 | 5 | 47 | |
| GSE47630 | WEE1 | 7465 | 3 | 11 | 26 | |
| GSE54993 | WEE1 | 7465 | 3 | 1 | 66 | |
| GSE54994 | WEE1 | 7465 | 2 | 13 | 38 | |
| GSE60625 | WEE1 | 7465 | 0 | 0 | 11 | |
| GSE74703 | WEE1 | 7465 | 1 | 4 | 31 | |
| GSE74704 | WEE1 | 7465 | 0 | 7 | 13 | |
| TCGA | WEE1 | 7465 | 11 | 33 | 52 |
Total number of gains: 28; Total number of losses: 98; Total Number of normals: 362.
Somatic mutations of WEE1:
Generating mutation plots.
Highly correlated genes for WEE1:
Showing top 20/210 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| WEE1 | WWC3 | 0.867522 | 3 | 0 | 3 |
| WEE1 | DOCK1 | 0.811442 | 3 | 0 | 3 |
| WEE1 | RNF214 | 0.778893 | 3 | 0 | 3 |
| WEE1 | RARB | 0.769392 | 3 | 0 | 3 |
| WEE1 | FAM76B | 0.758063 | 3 | 0 | 3 |
| WEE1 | SPRED2 | 0.741994 | 3 | 0 | 3 |
| WEE1 | ZNF512 | 0.740081 | 3 | 0 | 3 |
| WEE1 | AKIRIN1 | 0.738709 | 3 | 0 | 3 |
| WEE1 | ING4 | 0.732929 | 3 | 0 | 3 |
| WEE1 | RBM4B | 0.727386 | 3 | 0 | 3 |
| WEE1 | TXNDC16 | 0.717086 | 3 | 0 | 3 |
| WEE1 | REEP1 | 0.709423 | 3 | 0 | 3 |
| WEE1 | ZNF490 | 0.705259 | 3 | 0 | 3 |
| WEE1 | LRP6 | 0.70289 | 3 | 0 | 3 |
| WEE1 | FAM122B | 0.693735 | 3 | 0 | 3 |
| WEE1 | C12orf57 | 0.693272 | 3 | 0 | 3 |
| WEE1 | C11orf68 | 0.683599 | 4 | 0 | 3 |
| WEE1 | ZNF704 | 0.680112 | 3 | 0 | 3 |
| WEE1 | HNRNPH3 | 0.676646 | 3 | 0 | 3 |
| WEE1 | IRS2 | 0.674665 | 4 | 0 | 4 |
For details and further investigation, click here
