| Full name: methionine adenosyltransferase 2B | Alias Symbol: MATIIbeta|SDR23E1 | ||
| Type: protein-coding gene | Cytoband: 5q34 | ||
| Entrez ID: 27430 | HGNC ID: HGNC:6905 | Ensembl Gene: ENSG00000038274 | OMIM ID: 605527 |
| Drug and gene relationship at DGIdb | |||
Expression of MAT2B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MAT2B | 27430 | 217993_s_at | 0.1141 | 0.8004 | |
| GSE20347 | MAT2B | 27430 | 217993_s_at | -0.1200 | 0.4445 | |
| GSE23400 | MAT2B | 27430 | 217993_s_at | 0.2844 | 0.0001 | |
| GSE26886 | MAT2B | 27430 | 217993_s_at | -0.6948 | 0.0014 | |
| GSE29001 | MAT2B | 27430 | 217993_s_at | 0.0358 | 0.9165 | |
| GSE38129 | MAT2B | 27430 | 217993_s_at | -0.0976 | 0.3954 | |
| GSE45670 | MAT2B | 27430 | 217993_s_at | -0.1688 | 0.2609 | |
| GSE53622 | MAT2B | 27430 | 49377 | -0.0699 | 0.2428 | |
| GSE53624 | MAT2B | 27430 | 36792 | -0.2141 | 0.0582 | |
| GSE63941 | MAT2B | 27430 | 217993_s_at | 0.3288 | 0.3832 | |
| GSE77861 | MAT2B | 27430 | 217993_s_at | -0.2881 | 0.1551 | |
| GSE97050 | MAT2B | 27430 | A_33_P3246543 | -0.1637 | 0.5294 | |
| SRP007169 | MAT2B | 27430 | RNAseq | 0.2369 | 0.6314 | |
| SRP008496 | MAT2B | 27430 | RNAseq | 0.1670 | 0.5801 | |
| SRP064894 | MAT2B | 27430 | RNAseq | -0.1032 | 0.5884 | |
| SRP133303 | MAT2B | 27430 | RNAseq | 0.1087 | 0.5091 | |
| SRP159526 | MAT2B | 27430 | RNAseq | -0.3156 | 0.4578 | |
| SRP193095 | MAT2B | 27430 | RNAseq | -0.4827 | 0.0001 | |
| SRP219564 | MAT2B | 27430 | RNAseq | -0.0385 | 0.8833 | |
| TCGA | MAT2B | 27430 | RNAseq | 0.0377 | 0.4274 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by MAT2B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MAT2B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MAT2B | 27430 | 0 | 12 | 18 | |
| GSE20123 | MAT2B | 27430 | 0 | 12 | 18 | |
| GSE43470 | MAT2B | 27430 | 2 | 10 | 31 | |
| GSE46452 | MAT2B | 27430 | 0 | 27 | 32 | |
| GSE47630 | MAT2B | 27430 | 0 | 20 | 20 | |
| GSE54993 | MAT2B | 27430 | 9 | 2 | 59 | |
| GSE54994 | MAT2B | 27430 | 2 | 15 | 36 | |
| GSE60625 | MAT2B | 27430 | 1 | 0 | 10 | |
| GSE74703 | MAT2B | 27430 | 2 | 8 | 26 | |
| GSE74704 | MAT2B | 27430 | 0 | 7 | 13 | |
| TCGA | MAT2B | 27430 | 6 | 38 | 52 |
Total number of gains: 22; Total number of losses: 151; Total Number of normals: 315.
Somatic mutations of MAT2B:
Generating mutation plots.
Highly correlated genes for MAT2B:
Showing top 20/702 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MAT2B | LMBR1 | 0.78308 | 3 | 0 | 3 |
| MAT2B | SNUPN | 0.758597 | 3 | 0 | 3 |
| MAT2B | PPP4R1 | 0.752519 | 3 | 0 | 3 |
| MAT2B | CLP1 | 0.751798 | 3 | 0 | 3 |
| MAT2B | RABGAP1L | 0.751111 | 3 | 0 | 3 |
| MAT2B | NAGA | 0.744424 | 3 | 0 | 3 |
| MAT2B | TRIP12 | 0.742457 | 3 | 0 | 3 |
| MAT2B | TMEM218 | 0.741994 | 3 | 0 | 3 |
| MAT2B | LAMTOR3 | 0.739226 | 4 | 0 | 4 |
| MAT2B | GRAMD1C | 0.738176 | 3 | 0 | 3 |
| MAT2B | DNAJB14 | 0.73402 | 5 | 0 | 4 |
| MAT2B | FOXJ2 | 0.730428 | 3 | 0 | 3 |
| MAT2B | ARL4C | 0.729456 | 3 | 0 | 3 |
| MAT2B | COQ3 | 0.726569 | 3 | 0 | 3 |
| MAT2B | XPO1 | 0.724853 | 3 | 0 | 3 |
| MAT2B | RARB | 0.720293 | 3 | 0 | 3 |
| MAT2B | ABHD2 | 0.718089 | 3 | 0 | 3 |
| MAT2B | SDHD | 0.717208 | 4 | 0 | 4 |
| MAT2B | CCL28 | 0.716472 | 3 | 0 | 3 |
| MAT2B | RAB21 | 0.713963 | 4 | 0 | 3 |
For details and further investigation, click here
