RHOB

 

Full name: ras homolog family member B Alias Symbol: RhoB|RHOH6|MST081
Type: protein-coding gene Cytoband: 2p24.1
Entrez ID: 388 HGNC ID: HGNC:668 Ensembl Gene: ENSG00000143878 OMIM ID: 165370
Drug and gene relationship at DGIdb
Screen Evidence:
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of RHOB:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 RHOB 388 212099_at -0.8122 0.2533
GSE20347 RHOB 388 212099_at 0.2113 0.5537
GSE23400 RHOB 388 212099_at -0.1533 0.4277
GSE26886 RHOB 388 212099_at 2.2074 0.0002
GSE29001 RHOB 388 212099_at 0.0133 0.9795
GSE38129 RHOB 388 212099_at -0.6093 0.1054
GSE45670 RHOB 388 212099_at -1.3036 0.0002
GSE53622 RHOB 388 79151 -0.4960 0.0002
GSE53624 RHOB 388 79151 -0.1594 0.1610
GSE63941 RHOB 388 212099_at 0.8454 0.5752
GSE77861 RHOB 388 212099_at 1.4196 0.0056
GSE97050 RHOB 388 A_33_P3398862 -0.7227 0.3072
SRP007169 RHOB 388 RNAseq 0.1348 0.7636
SRP008496 RHOB 388 RNAseq 0.5609 0.0552
SRP064894 RHOB 388 RNAseq -0.2148 0.4367
SRP133303 RHOB 388 RNAseq 0.1611 0.6672
SRP159526 RHOB 388 RNAseq 0.0608 0.8570
SRP193095 RHOB 388 RNAseq 1.2557 0.0000
SRP219564 RHOB 388 RNAseq 0.5602 0.3722
TCGA RHOB 388 RNAseq -0.2605 0.0009

Upregulated datasets: 3; Downregulated datasets: 1.  

 

Survival by RHOB expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of RHOB:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 RHOB 388 10 2 18
GSE20123 RHOB 388 10 2 18
GSE43470 RHOB 388 2 0 41
GSE46452 RHOB 388 3 4 52
GSE47630 RHOB 388 7 0 33
GSE54993 RHOB 388 0 7 63
GSE54994 RHOB 388 11 0 42
GSE60625 RHOB 388 0 3 8
GSE74703 RHOB 388 2 0 34
GSE74704 RHOB 388 8 2 10
TCGA RHOB 388 36 2 58

Total number of gains: 89; Total number of losses: 22; Total Number of normals: 377.  

 

Somatic mutations of RHOB:

 

Generating mutation plots.

 

Highly correlated genes for RHOB:

 

Showing top 20/885 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
RHOBCORO2B0.790166505
RHOBC11orf960.763111404
RHOBWSCD20.761474303
RHOBANP32B0.757214303
RHOBRAD23A0.746805303
RHOBMRVI10.744928404
RHOBSLC35F10.743211303
RHOBFGF120.738779303
RHOBALKBH60.729814303
RHOBMYOCD0.724261404
RHOBTCEAL30.722506404
RHOBLINC007020.72198303
RHOBASB50.721628404
RHOBNUCKS10.721128303
RHOBB3GNT90.718389303
RHOBSNAPC20.716307404
RHOBPRKG20.715923303
RHOBTGFB1I10.71438910010
RHOBEID30.714381303
RHOBZNF5580.713247303

For details and further investigation, click here