| Full name: protein kinase cGMP-dependent 2 | Alias Symbol: cGKII|PRKGR2|PKG2 | ||
| Type: protein-coding gene | Cytoband: 4q21.21 | ||
| Entrez ID: 5593 | HGNC ID: HGNC:9416 | Ensembl Gene: ENSG00000138669 | OMIM ID: 601591 |
| Drug and gene relationship at DGIdb | |||
PRKG2 involved pathways:
Expression of PRKG2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PRKG2 | 5593 | 207505_at | -0.1815 | 0.8001 | |
| GSE20347 | PRKG2 | 5593 | 207505_at | 0.0544 | 0.5183 | |
| GSE23400 | PRKG2 | 5593 | 207505_at | -0.0027 | 0.9447 | |
| GSE26886 | PRKG2 | 5593 | 207505_at | 0.0779 | 0.7723 | |
| GSE29001 | PRKG2 | 5593 | 207505_at | -0.0986 | 0.3995 | |
| GSE38129 | PRKG2 | 5593 | 207505_at | -0.0981 | 0.2867 | |
| GSE45670 | PRKG2 | 5593 | 207505_at | -0.0091 | 0.9621 | |
| GSE53622 | PRKG2 | 5593 | 52584 | -0.5148 | 0.0110 | |
| GSE53624 | PRKG2 | 5593 | 52584 | -0.6278 | 0.0000 | |
| GSE63941 | PRKG2 | 5593 | 207505_at | -0.2716 | 0.3934 | |
| GSE77861 | PRKG2 | 5593 | 207505_at | 0.0716 | 0.5160 | |
| GSE97050 | PRKG2 | 5593 | A_33_P3342598 | -1.1524 | 0.2018 | |
| SRP007169 | PRKG2 | 5593 | RNAseq | 1.2615 | 0.0821 | |
| SRP064894 | PRKG2 | 5593 | RNAseq | -0.6644 | 0.0448 | |
| SRP133303 | PRKG2 | 5593 | RNAseq | -0.0940 | 0.8399 | |
| SRP159526 | PRKG2 | 5593 | RNAseq | 0.9325 | 0.1668 | |
| SRP219564 | PRKG2 | 5593 | RNAseq | 0.0104 | 0.9912 | |
| TCGA | PRKG2 | 5593 | RNAseq | -0.1312 | 0.6664 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by PRKG2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PRKG2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PRKG2 | 5593 | 1 | 10 | 19 | |
| GSE20123 | PRKG2 | 5593 | 1 | 10 | 19 | |
| GSE43470 | PRKG2 | 5593 | 0 | 13 | 30 | |
| GSE46452 | PRKG2 | 5593 | 1 | 36 | 22 | |
| GSE47630 | PRKG2 | 5593 | 1 | 19 | 20 | |
| GSE54993 | PRKG2 | 5593 | 8 | 0 | 62 | |
| GSE54994 | PRKG2 | 5593 | 0 | 9 | 44 | |
| GSE60625 | PRKG2 | 5593 | 0 | 0 | 11 | |
| GSE74703 | PRKG2 | 5593 | 0 | 11 | 25 | |
| GSE74704 | PRKG2 | 5593 | 1 | 5 | 14 | |
| TCGA | PRKG2 | 5593 | 11 | 34 | 51 |
Total number of gains: 24; Total number of losses: 147; Total Number of normals: 317.
Somatic mutations of PRKG2:
Generating mutation plots.
Highly correlated genes for PRKG2:
Showing top 20/458 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PRKG2 | OCRL | 0.820504 | 3 | 0 | 3 |
| PRKG2 | IQUB | 0.810149 | 3 | 0 | 3 |
| PRKG2 | ILK | 0.78799 | 3 | 0 | 3 |
| PRKG2 | KATNAL1 | 0.780346 | 3 | 0 | 3 |
| PRKG2 | MRPL33 | 0.778866 | 3 | 0 | 3 |
| PRKG2 | TGFB1I1 | 0.75393 | 3 | 0 | 3 |
| PRKG2 | COL28A1 | 0.749533 | 3 | 0 | 3 |
| PRKG2 | DIAPH2 | 0.738901 | 3 | 0 | 3 |
| PRKG2 | NPY | 0.735785 | 3 | 0 | 3 |
| PRKG2 | CLEC1A | 0.734942 | 3 | 0 | 3 |
| PRKG2 | ANKRD40 | 0.734459 | 4 | 0 | 3 |
| PRKG2 | SLC25A25 | 0.729829 | 3 | 0 | 3 |
| PRKG2 | EGR3 | 0.725261 | 3 | 0 | 3 |
| PRKG2 | SPRYD3 | 0.724724 | 3 | 0 | 3 |
| PRKG2 | JMY | 0.71905 | 3 | 0 | 3 |
| PRKG2 | RHOB | 0.715923 | 3 | 0 | 3 |
| PRKG2 | FLNA | 0.713169 | 4 | 0 | 3 |
| PRKG2 | ITGA1 | 0.707443 | 3 | 0 | 3 |
| PRKG2 | TTBK2 | 0.706989 | 3 | 0 | 3 |
| PRKG2 | PITPNM3 | 0.699752 | 3 | 0 | 3 |
For details and further investigation, click here
