| Full name: nuclear casein kinase and cyclin dependent kinase substrate 1 | Alias Symbol: NUCKS | ||
| Type: protein-coding gene | Cytoband: 1q32.1 | ||
| Entrez ID: 64710 | HGNC ID: HGNC:29923 | Ensembl Gene: ENSG00000069275 | OMIM ID: 611912 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of NUCKS1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NUCKS1 | 64710 | 217802_s_at | 0.4294 | 0.4702 | |
| GSE20347 | NUCKS1 | 64710 | 217802_s_at | 0.4504 | 0.0001 | |
| GSE23400 | NUCKS1 | 64710 | 217802_s_at | 0.4313 | 0.0000 | |
| GSE26886 | NUCKS1 | 64710 | 229353_s_at | 0.6773 | 0.0001 | |
| GSE29001 | NUCKS1 | 64710 | 217802_s_at | 0.4991 | 0.0022 | |
| GSE38129 | NUCKS1 | 64710 | 217802_s_at | 0.3531 | 0.0008 | |
| GSE45670 | NUCKS1 | 64710 | 229353_s_at | 0.6133 | 0.0018 | |
| GSE53622 | NUCKS1 | 64710 | 92382 | 0.2152 | 0.0031 | |
| GSE53624 | NUCKS1 | 64710 | 92382 | 0.4380 | 0.0000 | |
| GSE63941 | NUCKS1 | 64710 | 226880_at | 3.2461 | 0.0000 | |
| GSE77861 | NUCKS1 | 64710 | 229353_s_at | 0.9441 | 0.0063 | |
| GSE97050 | NUCKS1 | 64710 | A_24_P374652 | -0.0681 | 0.8450 | |
| SRP007169 | NUCKS1 | 64710 | RNAseq | 1.0570 | 0.0040 | |
| SRP008496 | NUCKS1 | 64710 | RNAseq | 1.3798 | 0.0000 | |
| SRP064894 | NUCKS1 | 64710 | RNAseq | 0.6001 | 0.0027 | |
| SRP133303 | NUCKS1 | 64710 | RNAseq | 0.5262 | 0.0021 | |
| SRP159526 | NUCKS1 | 64710 | RNAseq | 0.8540 | 0.0000 | |
| SRP193095 | NUCKS1 | 64710 | RNAseq | 0.3934 | 0.0028 | |
| SRP219564 | NUCKS1 | 64710 | RNAseq | 0.5531 | 0.0823 | |
| TCGA | NUCKS1 | 64710 | RNAseq | 0.0775 | 0.0756 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by NUCKS1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NUCKS1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NUCKS1 | 64710 | 11 | 0 | 19 | |
| GSE20123 | NUCKS1 | 64710 | 11 | 0 | 19 | |
| GSE43470 | NUCKS1 | 64710 | 7 | 0 | 36 | |
| GSE46452 | NUCKS1 | 64710 | 3 | 1 | 55 | |
| GSE47630 | NUCKS1 | 64710 | 14 | 0 | 26 | |
| GSE54993 | NUCKS1 | 64710 | 0 | 6 | 64 | |
| GSE54994 | NUCKS1 | 64710 | 15 | 0 | 38 | |
| GSE60625 | NUCKS1 | 64710 | 0 | 0 | 11 | |
| GSE74703 | NUCKS1 | 64710 | 7 | 0 | 29 | |
| GSE74704 | NUCKS1 | 64710 | 5 | 0 | 15 | |
| TCGA | NUCKS1 | 64710 | 43 | 5 | 48 |
Total number of gains: 116; Total number of losses: 12; Total Number of normals: 360.
Somatic mutations of NUCKS1:
Generating mutation plots.
Highly correlated genes for NUCKS1:
Showing top 20/1298 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NUCKS1 | UTP23 | 0.800592 | 4 | 0 | 3 |
| NUCKS1 | CPT1A | 0.800036 | 3 | 0 | 3 |
| NUCKS1 | EIF3C | 0.786333 | 3 | 0 | 3 |
| NUCKS1 | MRPS26 | 0.783335 | 3 | 0 | 3 |
| NUCKS1 | MRPS22 | 0.760344 | 3 | 0 | 3 |
| NUCKS1 | HES4 | 0.760143 | 3 | 0 | 3 |
| NUCKS1 | HNRNPAB | 0.757487 | 3 | 0 | 3 |
| NUCKS1 | EEF1D | 0.757158 | 5 | 0 | 5 |
| NUCKS1 | STRN4 | 0.751838 | 3 | 0 | 3 |
| NUCKS1 | METTL8 | 0.739722 | 4 | 0 | 4 |
| NUCKS1 | ALKBH6 | 0.738855 | 5 | 0 | 4 |
| NUCKS1 | GATAD2B | 0.738596 | 4 | 0 | 4 |
| NUCKS1 | DEDD | 0.735101 | 3 | 0 | 3 |
| NUCKS1 | CTNNBL1 | 0.733376 | 3 | 0 | 3 |
| NUCKS1 | EFTUD2 | 0.733016 | 5 | 0 | 5 |
| NUCKS1 | PPP1R35 | 0.731169 | 4 | 0 | 4 |
| NUCKS1 | RNASEH2C | 0.728854 | 3 | 0 | 3 |
| NUCKS1 | SLC25A29 | 0.726948 | 4 | 0 | 3 |
| NUCKS1 | REL | 0.725685 | 4 | 0 | 3 |
| NUCKS1 | ZC3H18 | 0.725653 | 4 | 0 | 4 |
For details and further investigation, click here
