| Full name: RIO kinase 2 | Alias Symbol: FLJ11159 | ||
| Type: protein-coding gene | Cytoband: 5q15 | ||
| Entrez ID: 55781 | HGNC ID: HGNC:18999 | Ensembl Gene: ENSG00000058729 | OMIM ID: 617754 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of RIOK2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RIOK2 | 55781 | 218535_s_at | -0.0183 | 0.9830 | |
| GSE20347 | RIOK2 | 55781 | 218535_s_at | -0.0176 | 0.9335 | |
| GSE23400 | RIOK2 | 55781 | 218535_s_at | 0.2014 | 0.0012 | |
| GSE26886 | RIOK2 | 55781 | 218535_s_at | -0.3377 | 0.3009 | |
| GSE29001 | RIOK2 | 55781 | 218535_s_at | 0.2597 | 0.4980 | |
| GSE38129 | RIOK2 | 55781 | 218535_s_at | 0.0530 | 0.6967 | |
| GSE45670 | RIOK2 | 55781 | 218535_s_at | 0.1873 | 0.2876 | |
| GSE63941 | RIOK2 | 55781 | 218535_s_at | -0.4825 | 0.2590 | |
| GSE77861 | RIOK2 | 55781 | 218535_s_at | -0.2108 | 0.4287 | |
| GSE97050 | RIOK2 | 55781 | A_23_P133284 | 0.0902 | 0.7082 | |
| SRP007169 | RIOK2 | 55781 | RNAseq | -0.0873 | 0.8344 | |
| SRP008496 | RIOK2 | 55781 | RNAseq | 0.0841 | 0.7636 | |
| SRP064894 | RIOK2 | 55781 | RNAseq | -0.1613 | 0.3760 | |
| SRP133303 | RIOK2 | 55781 | RNAseq | 0.3057 | 0.0377 | |
| SRP159526 | RIOK2 | 55781 | RNAseq | -0.1059 | 0.7767 | |
| SRP193095 | RIOK2 | 55781 | RNAseq | -0.4315 | 0.0000 | |
| SRP219564 | RIOK2 | 55781 | RNAseq | -0.3098 | 0.3457 | |
| TCGA | RIOK2 | 55781 | RNAseq | -0.1570 | 0.0043 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by RIOK2 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of RIOK2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RIOK2 | 55781 | 1 | 13 | 16 | |
| GSE20123 | RIOK2 | 55781 | 1 | 13 | 16 | |
| GSE43470 | RIOK2 | 55781 | 3 | 9 | 31 | |
| GSE46452 | RIOK2 | 55781 | 0 | 28 | 31 | |
| GSE47630 | RIOK2 | 55781 | 0 | 20 | 20 | |
| GSE54993 | RIOK2 | 55781 | 8 | 1 | 61 | |
| GSE54994 | RIOK2 | 55781 | 1 | 18 | 34 | |
| GSE60625 | RIOK2 | 55781 | 0 | 0 | 11 | |
| GSE74703 | RIOK2 | 55781 | 2 | 7 | 27 | |
| GSE74704 | RIOK2 | 55781 | 1 | 7 | 12 | |
| TCGA | RIOK2 | 55781 | 3 | 43 | 50 |
Total number of gains: 20; Total number of losses: 159; Total Number of normals: 309.
Somatic mutations of RIOK2:
Generating mutation plots.
Highly correlated genes for RIOK2:
Showing top 20/492 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RIOK2 | ARL10 | 0.826805 | 3 | 0 | 3 |
| RIOK2 | COG3 | 0.813658 | 3 | 0 | 3 |
| RIOK2 | CHURC1 | 0.798708 | 3 | 0 | 3 |
| RIOK2 | PEX2 | 0.77726 | 3 | 0 | 3 |
| RIOK2 | DNAJC15 | 0.775443 | 3 | 0 | 3 |
| RIOK2 | PDZD11 | 0.765531 | 3 | 0 | 3 |
| RIOK2 | CD164 | 0.764012 | 3 | 0 | 3 |
| RIOK2 | AP4E1 | 0.762948 | 3 | 0 | 3 |
| RIOK2 | PEX19 | 0.760208 | 3 | 0 | 3 |
| RIOK2 | SREK1IP1 | 0.74946 | 3 | 0 | 3 |
| RIOK2 | NEDD8 | 0.744804 | 4 | 0 | 3 |
| RIOK2 | POLR3F | 0.744222 | 3 | 0 | 3 |
| RIOK2 | TACO1 | 0.743315 | 3 | 0 | 3 |
| RIOK2 | VAPA | 0.742461 | 3 | 0 | 3 |
| RIOK2 | ELP4 | 0.742105 | 4 | 0 | 4 |
| RIOK2 | FYTTD1 | 0.73774 | 3 | 0 | 3 |
| RIOK2 | P2RX7 | 0.730911 | 3 | 0 | 3 |
| RIOK2 | PARP2 | 0.727857 | 4 | 0 | 3 |
| RIOK2 | RMND1 | 0.727433 | 3 | 0 | 3 |
| RIOK2 | TMEM161B | 0.723552 | 4 | 0 | 4 |
For details and further investigation, click here
