| Full name: adaptor related protein complex 4 subunit epsilon 1 | Alias Symbol: AP-4-EPSILON|SPG51 | ||
| Type: protein-coding gene | Cytoband: 15q21.2 | ||
| Entrez ID: 23431 | HGNC ID: HGNC:573 | Ensembl Gene: ENSG00000081014 | OMIM ID: 607244 |
| Drug and gene relationship at DGIdb | |||
Expression of AP4E1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | AP4E1 | 23431 | 228164_at | -0.0329 | 0.9684 | |
| GSE20347 | AP4E1 | 23431 | 220229_s_at | -0.0272 | 0.6170 | |
| GSE23400 | AP4E1 | 23431 | 220229_s_at | -0.0277 | 0.1641 | |
| GSE26886 | AP4E1 | 23431 | 228164_at | -0.3080 | 0.2169 | |
| GSE29001 | AP4E1 | 23431 | 220229_s_at | -0.1243 | 0.2374 | |
| GSE38129 | AP4E1 | 23431 | 220229_s_at | -0.0334 | 0.5446 | |
| GSE45670 | AP4E1 | 23431 | 228164_at | -0.0747 | 0.6964 | |
| GSE53622 | AP4E1 | 23431 | 105968 | -0.4142 | 0.0000 | |
| GSE53624 | AP4E1 | 23431 | 48093 | -0.2661 | 0.0000 | |
| GSE63941 | AP4E1 | 23431 | 228164_at | -1.1850 | 0.0112 | |
| GSE77861 | AP4E1 | 23431 | 228164_at | -0.1365 | 0.6478 | |
| GSE97050 | AP4E1 | 23431 | A_24_P929369 | -0.1966 | 0.4138 | |
| SRP007169 | AP4E1 | 23431 | RNAseq | -0.0554 | 0.8673 | |
| SRP008496 | AP4E1 | 23431 | RNAseq | 0.0527 | 0.8050 | |
| SRP064894 | AP4E1 | 23431 | RNAseq | -0.3262 | 0.1476 | |
| SRP133303 | AP4E1 | 23431 | RNAseq | 0.1098 | 0.4305 | |
| SRP159526 | AP4E1 | 23431 | RNAseq | -0.4640 | 0.1152 | |
| SRP193095 | AP4E1 | 23431 | RNAseq | -0.1559 | 0.0944 | |
| SRP219564 | AP4E1 | 23431 | RNAseq | -0.5104 | 0.0531 | |
| TCGA | AP4E1 | 23431 | RNAseq | 0.0964 | 0.1172 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by AP4E1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of AP4E1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | AP4E1 | 23431 | 5 | 3 | 22 | |
| GSE20123 | AP4E1 | 23431 | 5 | 3 | 22 | |
| GSE43470 | AP4E1 | 23431 | 5 | 3 | 35 | |
| GSE46452 | AP4E1 | 23431 | 3 | 7 | 49 | |
| GSE47630 | AP4E1 | 23431 | 8 | 10 | 22 | |
| GSE54993 | AP4E1 | 23431 | 4 | 6 | 60 | |
| GSE54994 | AP4E1 | 23431 | 5 | 7 | 41 | |
| GSE60625 | AP4E1 | 23431 | 4 | 0 | 7 | |
| GSE74703 | AP4E1 | 23431 | 5 | 2 | 29 | |
| GSE74704 | AP4E1 | 23431 | 2 | 3 | 15 | |
| TCGA | AP4E1 | 23431 | 9 | 16 | 71 |
Total number of gains: 55; Total number of losses: 60; Total Number of normals: 373.
Somatic mutations of AP4E1:
Generating mutation plots.
Highly correlated genes for AP4E1:
Showing top 20/469 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| AP4E1 | PLEKHM3 | 0.790222 | 3 | 0 | 3 |
| AP4E1 | USP32 | 0.765467 | 3 | 0 | 3 |
| AP4E1 | RIOK2 | 0.762948 | 3 | 0 | 3 |
| AP4E1 | BPGM | 0.758793 | 3 | 0 | 3 |
| AP4E1 | KIAA0355 | 0.743106 | 3 | 0 | 3 |
| AP4E1 | SNRPA1 | 0.740942 | 3 | 0 | 3 |
| AP4E1 | ANKRD13C | 0.739557 | 5 | 0 | 5 |
| AP4E1 | ZCCHC10 | 0.735062 | 4 | 0 | 4 |
| AP4E1 | LYRM7 | 0.732729 | 3 | 0 | 3 |
| AP4E1 | CCDC25 | 0.731268 | 3 | 0 | 3 |
| AP4E1 | PRELID1 | 0.720388 | 3 | 0 | 3 |
| AP4E1 | SUSD1 | 0.719468 | 3 | 0 | 3 |
| AP4E1 | SLC25A30 | 0.71895 | 3 | 0 | 3 |
| AP4E1 | WDR73 | 0.718664 | 3 | 0 | 3 |
| AP4E1 | LRIF1 | 0.712932 | 3 | 0 | 3 |
| AP4E1 | ATL1 | 0.712579 | 3 | 0 | 3 |
| AP4E1 | PPIP5K2 | 0.712203 | 4 | 0 | 4 |
| AP4E1 | FAHD1 | 0.712014 | 4 | 0 | 3 |
| AP4E1 | SNAP23 | 0.711894 | 4 | 0 | 3 |
| AP4E1 | FBXO42 | 0.711436 | 3 | 0 | 3 |
For details and further investigation, click here
