| Full name: purinergic receptor P2X 7 | Alias Symbol: P2X7|MGC20089 | ||
| Type: protein-coding gene | Cytoband: 12q24.31 | ||
| Entrez ID: 5027 | HGNC ID: HGNC:8537 | Ensembl Gene: ENSG00000089041 | OMIM ID: 602566 |
| Drug and gene relationship at DGIdb | |||
P2RX7 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04020 | Calcium signaling pathway |
Expression of P2RX7:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | P2RX7 | 5027 | 230741_at | 0.3972 | 0.6280 | |
| GSE20347 | P2RX7 | 5027 | 207091_at | -0.1566 | 0.0440 | |
| GSE23400 | P2RX7 | 5027 | 207091_at | -0.1081 | 0.0002 | |
| GSE26886 | P2RX7 | 5027 | 230741_at | 0.0691 | 0.9053 | |
| GSE29001 | P2RX7 | 5027 | 207091_at | 0.0856 | 0.5483 | |
| GSE38129 | P2RX7 | 5027 | 207091_at | -0.0788 | 0.3637 | |
| GSE45670 | P2RX7 | 5027 | 230741_at | -0.4083 | 0.2320 | |
| GSE53622 | P2RX7 | 5027 | 55321 | 0.2717 | 0.0066 | |
| GSE53624 | P2RX7 | 5027 | 55321 | 0.3819 | 0.0000 | |
| GSE63941 | P2RX7 | 5027 | 230741_at | -1.9154 | 0.0188 | |
| GSE77861 | P2RX7 | 5027 | 207091_at | -0.0827 | 0.5275 | |
| GSE97050 | P2RX7 | 5027 | A_33_P3263867 | 0.0968 | 0.7054 | |
| SRP007169 | P2RX7 | 5027 | RNAseq | 0.8784 | 0.1733 | |
| SRP008496 | P2RX7 | 5027 | RNAseq | 0.8174 | 0.1025 | |
| SRP064894 | P2RX7 | 5027 | RNAseq | 0.7038 | 0.0141 | |
| SRP133303 | P2RX7 | 5027 | RNAseq | 0.2918 | 0.2080 | |
| SRP159526 | P2RX7 | 5027 | RNAseq | -0.6054 | 0.3137 | |
| SRP193095 | P2RX7 | 5027 | RNAseq | 0.4391 | 0.0013 | |
| SRP219564 | P2RX7 | 5027 | RNAseq | -0.3490 | 0.4585 | |
| TCGA | P2RX7 | 5027 | RNAseq | 0.2778 | 0.1706 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by P2RX7 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of P2RX7:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | P2RX7 | 5027 | 6 | 3 | 21 | |
| GSE20123 | P2RX7 | 5027 | 6 | 3 | 21 | |
| GSE43470 | P2RX7 | 5027 | 2 | 2 | 39 | |
| GSE46452 | P2RX7 | 5027 | 9 | 1 | 49 | |
| GSE47630 | P2RX7 | 5027 | 9 | 3 | 28 | |
| GSE54993 | P2RX7 | 5027 | 0 | 5 | 65 | |
| GSE54994 | P2RX7 | 5027 | 6 | 7 | 40 | |
| GSE60625 | P2RX7 | 5027 | 0 | 0 | 11 | |
| GSE74703 | P2RX7 | 5027 | 2 | 1 | 33 | |
| GSE74704 | P2RX7 | 5027 | 3 | 2 | 15 | |
| TCGA | P2RX7 | 5027 | 21 | 11 | 64 |
Total number of gains: 64; Total number of losses: 38; Total Number of normals: 386.
Somatic mutations of P2RX7:
Generating mutation plots.
Highly correlated genes for P2RX7:
Showing top 20/122 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| P2RX7 | KIAA0513 | 0.777066 | 3 | 0 | 3 |
| P2RX7 | AP4S1 | 0.762176 | 3 | 0 | 3 |
| P2RX7 | ABLIM2 | 0.742474 | 3 | 0 | 3 |
| P2RX7 | RAD17 | 0.739126 | 3 | 0 | 3 |
| P2RX7 | RIOK2 | 0.730911 | 3 | 0 | 3 |
| P2RX7 | ARV1 | 0.728615 | 3 | 0 | 3 |
| P2RX7 | VPS26B | 0.722614 | 3 | 0 | 3 |
| P2RX7 | MFN2 | 0.721421 | 3 | 0 | 3 |
| P2RX7 | PAQR7 | 0.717531 | 3 | 0 | 3 |
| P2RX7 | NAGA | 0.705828 | 3 | 0 | 3 |
| P2RX7 | DNAJC11 | 0.701535 | 3 | 0 | 3 |
| P2RX7 | SNRNP35 | 0.699974 | 3 | 0 | 3 |
| P2RX7 | PPP6R2 | 0.677316 | 3 | 0 | 3 |
| P2RX7 | NCOA6 | 0.669227 | 4 | 0 | 3 |
| P2RX7 | ARHGEF37 | 0.667665 | 3 | 0 | 3 |
| P2RX7 | RIPK3 | 0.665255 | 3 | 0 | 3 |
| P2RX7 | PTDSS2 | 0.663507 | 3 | 0 | 3 |
| P2RX7 | PI4K2A | 0.6553 | 4 | 0 | 3 |
| P2RX7 | HERC4 | 0.655082 | 3 | 0 | 3 |
| P2RX7 | SDHC | 0.649771 | 3 | 0 | 3 |
For details and further investigation, click here
