| Full name: NEDD8 ubiquitin like modifier | Alias Symbol: Nedd-8 | ||
| Type: protein-coding gene | Cytoband: 14q12 | ||
| Entrez ID: 4738 | HGNC ID: HGNC:7732 | Ensembl Gene: ENSG00000129559 | OMIM ID: 603171 |
| Drug and gene relationship at DGIdb | |||
Expression of NEDD8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NEDD8 | 4738 | 201840_at | 0.1990 | 0.8084 | |
| GSE20347 | NEDD8 | 4738 | 201840_at | 0.0828 | 0.6424 | |
| GSE23400 | NEDD8 | 4738 | 201840_at | 0.1934 | 0.0008 | |
| GSE26886 | NEDD8 | 4738 | 201840_at | 0.0084 | 0.9682 | |
| GSE29001 | NEDD8 | 4738 | 201840_at | 0.2566 | 0.4001 | |
| GSE38129 | NEDD8 | 4738 | 201840_at | 0.1049 | 0.4277 | |
| GSE45670 | NEDD8 | 4738 | 201840_at | 0.1454 | 0.3529 | |
| GSE53622 | NEDD8 | 4738 | 37934 | 0.2109 | 0.0032 | |
| GSE53624 | NEDD8 | 4738 | 37934 | 0.5002 | 0.0000 | |
| GSE63941 | NEDD8 | 4738 | 201840_at | -0.1511 | 0.7727 | |
| GSE77861 | NEDD8 | 4738 | 201840_at | 0.1446 | 0.6944 | |
| GSE97050 | NEDD8 | 4738 | A_23_P88420 | 0.2251 | 0.2903 | |
| SRP007169 | NEDD8 | 4738 | RNAseq | -0.2394 | 0.4440 | |
| SRP008496 | NEDD8 | 4738 | RNAseq | -0.2512 | 0.2330 | |
| SRP064894 | NEDD8 | 4738 | RNAseq | 0.4507 | 0.0998 | |
| SRP133303 | NEDD8 | 4738 | RNAseq | 0.4390 | 0.0661 | |
| SRP159526 | NEDD8 | 4738 | RNAseq | -0.0206 | 0.9217 | |
| SRP193095 | NEDD8 | 4738 | RNAseq | -0.1419 | 0.4587 | |
| SRP219564 | NEDD8 | 4738 | RNAseq | 0.0655 | 0.7560 | |
| TCGA | NEDD8 | 4738 | RNAseq | 0.1330 | 0.0097 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by NEDD8 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NEDD8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NEDD8 | 4738 | 8 | 3 | 19 | |
| GSE20123 | NEDD8 | 4738 | 8 | 3 | 19 | |
| GSE43470 | NEDD8 | 4738 | 8 | 2 | 33 | |
| GSE46452 | NEDD8 | 4738 | 16 | 2 | 41 | |
| GSE47630 | NEDD8 | 4738 | 11 | 10 | 19 | |
| GSE54993 | NEDD8 | 4738 | 3 | 11 | 56 | |
| GSE54994 | NEDD8 | 4738 | 18 | 5 | 30 | |
| GSE60625 | NEDD8 | 4738 | 0 | 2 | 9 | |
| GSE74703 | NEDD8 | 4738 | 7 | 2 | 27 | |
| GSE74704 | NEDD8 | 4738 | 3 | 2 | 15 | |
| TCGA | NEDD8 | 4738 | 27 | 13 | 56 |
Total number of gains: 109; Total number of losses: 55; Total Number of normals: 324.
Somatic mutations of NEDD8:
Generating mutation plots.
Highly correlated genes for NEDD8:
Showing top 20/457 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NEDD8 | SNRNP200 | 0.790418 | 3 | 0 | 3 |
| NEDD8 | ZNF787 | 0.771265 | 3 | 0 | 3 |
| NEDD8 | MRPL52 | 0.770168 | 8 | 0 | 8 |
| NEDD8 | C14orf119 | 0.760696 | 4 | 0 | 4 |
| NEDD8 | BRAT1 | 0.753175 | 3 | 0 | 3 |
| NEDD8 | RIOK2 | 0.744804 | 4 | 0 | 3 |
| NEDD8 | GMPR2 | 0.737213 | 13 | 0 | 13 |
| NEDD8 | MRPL32 | 0.733731 | 4 | 0 | 3 |
| NEDD8 | RAB12 | 0.732131 | 3 | 0 | 3 |
| NEDD8 | TM9SF1 | 0.718743 | 9 | 0 | 8 |
| NEDD8 | USP37 | 0.715144 | 3 | 0 | 3 |
| NEDD8 | APH1B | 0.713903 | 3 | 0 | 3 |
| NEDD8 | DAD1 | 0.712828 | 13 | 0 | 11 |
| NEDD8 | DDX54 | 0.7069 | 3 | 0 | 3 |
| NEDD8 | CSNK1A1 | 0.697965 | 3 | 0 | 3 |
| NEDD8 | RPL35A | 0.696798 | 3 | 0 | 3 |
| NEDD8 | ALDH7A1 | 0.695476 | 4 | 0 | 3 |
| NEDD8 | EXT2 | 0.694437 | 5 | 0 | 4 |
| NEDD8 | RNF145 | 0.692284 | 3 | 0 | 3 |
| NEDD8 | CHURC1 | 0.692115 | 5 | 0 | 4 |
For details and further investigation, click here
