PARP2

 

Full name: poly(ADP-ribose) polymerase 2 Alias Symbol: 
Type: protein-coding gene Cytoband: 14q11.2
Entrez ID: 10038 HGNC ID: HGNC:272 Ensembl Gene: ENSG00000129484 OMIM ID: 607725
Drug and gene relationship at DGIdb

 

PARP2 involved pathways:

KEGG pathway Description View
hsa04210Apoptosis

 

Expression of PARP2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 PARP2 10038 215773_x_at 0.0338 0.9570
GSE20347 PARP2 10038 204752_x_at 0.8049 0.0001
GSE23400 PARP2 10038 204752_x_at 0.4644 0.0000
GSE26886 PARP2 10038 215773_x_at 0.4246 0.0263
GSE29001 PARP2 10038 215773_x_at 0.5597 0.0303
GSE38129 PARP2 10038 215773_x_at 0.6592 0.0000
GSE45670 PARP2 10038 215773_x_at 0.4264 0.0097
GSE53622 PARP2 10038 25974 0.4772 0.0000
GSE53624 PARP2 10038 25974 0.7762 0.0000
GSE63941 PARP2 10038 204752_x_at 1.6104 0.0035
GSE77861 PARP2 10038 204752_x_at 0.7662 0.0353
GSE97050 PARP2 10038 A_23_P163027 0.4296 0.1443
SRP007169 PARP2 10038 RNAseq 1.7058 0.0001
SRP008496 PARP2 10038 RNAseq 1.2420 0.0004
SRP064894 PARP2 10038 RNAseq 0.7464 0.0002
SRP133303 PARP2 10038 RNAseq 0.4841 0.0053
SRP159526 PARP2 10038 RNAseq 0.7134 0.0247
SRP193095 PARP2 10038 RNAseq 0.5017 0.0000
SRP219564 PARP2 10038 RNAseq 0.3762 0.1680
TCGA PARP2 10038 RNAseq 0.2052 0.0009

Upregulated datasets: 3; Downregulated datasets: 0.  

 

Survival by PARP2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of PARP2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PARP2 10038 11 3 16
GSE20123 PARP2 10038 9 3 18
GSE43470 PARP2 10038 7 1 35
GSE46452 PARP2 10038 19 2 38
GSE47630 PARP2 10038 10 10 20
GSE54993 PARP2 10038 3 11 56
GSE54994 PARP2 10038 18 5 30
GSE60625 PARP2 10038 0 2 9
GSE74703 PARP2 10038 6 1 29
GSE74704 PARP2 10038 4 2 14
TCGA PARP2 10038 28 16 52

Total number of gains: 115; Total number of losses: 56; Total Number of normals: 317.  

 

Somatic mutations of PARP2:

 

Generating mutation plots.

 

Highly correlated genes for PARP2:

 

Showing top 20/1248 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PARP2GNAI10.812569303
PARP2RAB3GAP10.780231303
PARP2SUPT16H0.77271413013
PARP2ZNF3170.763274404
PARP2BICD20.744679303
PARP2BOD10.743423505
PARP2LCLAT10.740233303
PARP2APEX10.73157713012
PARP2RIOK20.727857403
PARP2NGDN0.72477113012
PARP2METTL170.7212551109
PARP2G2E30.719266606
PARP2SLC2A90.718655303
PARP2LRRC580.713562403
PARP2ALG10.71269303
PARP2CCNB1IP10.71234213011
PARP2RNF1300.710253404
PARP2SET0.708319403
PARP2KLF110.70809303
PARP2SPIRE10.703303

For details and further investigation, click here