| Full name: ribosomal protein L22 | Alias Symbol: EAP|L22 | ||
| Type: protein-coding gene | Cytoband: 1p36.31 | ||
| Entrez ID: 6146 | HGNC ID: HGNC:10315 | Ensembl Gene: ENSG00000116251 | OMIM ID: 180474 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of RPL22:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RPL22 | 6146 | 221775_x_at | 0.0467 | 0.9020 | |
| GSE20347 | RPL22 | 6146 | 221775_x_at | 0.0846 | 0.2368 | |
| GSE23400 | RPL22 | 6146 | 221775_x_at | 0.1093 | 0.0290 | |
| GSE26886 | RPL22 | 6146 | 208768_x_at | 0.3945 | 0.0007 | |
| GSE29001 | RPL22 | 6146 | 221775_x_at | -0.2454 | 0.2631 | |
| GSE38129 | RPL22 | 6146 | 221775_x_at | 0.1229 | 0.0474 | |
| GSE45670 | RPL22 | 6146 | 208768_x_at | -0.1086 | 0.1508 | |
| GSE53622 | RPL22 | 6146 | 59788 | -0.6887 | 0.0000 | |
| GSE53624 | RPL22 | 6146 | 59788 | -0.7860 | 0.0000 | |
| GSE63941 | RPL22 | 6146 | 220960_x_at | 0.3917 | 0.0369 | |
| GSE77861 | RPL22 | 6146 | 221775_x_at | -0.1610 | 0.3456 | |
| GSE97050 | RPL22 | A_21_P0011271 | -0.3329 | 0.4468 | ||
| SRP007169 | RPL22 | 6146 | RNAseq | -1.1718 | 0.0001 | |
| SRP008496 | RPL22 | 6146 | RNAseq | -0.9937 | 0.0000 | |
| SRP064894 | RPL22 | 6146 | RNAseq | -0.4252 | 0.1103 | |
| SRP133303 | RPL22 | 6146 | RNAseq | -0.4181 | 0.0049 | |
| SRP159526 | RPL22 | 6146 | RNAseq | -0.5673 | 0.0065 | |
| SRP193095 | RPL22 | 6146 | RNAseq | -0.9227 | 0.0000 | |
| SRP219564 | RPL22 | 6146 | RNAseq | -0.7324 | 0.0102 | |
| TCGA | RPL22 | 6146 | RNAseq | -0.0125 | 0.7860 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by RPL22 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RPL22:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RPL22 | 6146 | 3 | 6 | 21 | |
| GSE20123 | RPL22 | 6146 | 3 | 5 | 22 | |
| GSE43470 | RPL22 | 6146 | 6 | 5 | 32 | |
| GSE46452 | RPL22 | 6146 | 7 | 1 | 51 | |
| GSE47630 | RPL22 | 6146 | 8 | 4 | 28 | |
| GSE54993 | RPL22 | 6146 | 3 | 2 | 65 | |
| GSE54994 | RPL22 | 6146 | 14 | 3 | 36 | |
| GSE60625 | RPL22 | 6146 | 0 | 0 | 11 | |
| GSE74703 | RPL22 | 6146 | 5 | 3 | 28 | |
| GSE74704 | RPL22 | 6146 | 3 | 0 | 17 | |
| TCGA | RPL22 | 6146 | 12 | 22 | 62 |
Total number of gains: 64; Total number of losses: 51; Total Number of normals: 373.
Somatic mutations of RPL22:
Generating mutation plots.
Highly correlated genes for RPL22:
Showing top 20/83 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RPL22 | MRPL43 | 0.704808 | 4 | 0 | 4 |
| RPL22 | ZNF879 | 0.697595 | 3 | 0 | 3 |
| RPL22 | NADK2 | 0.688527 | 3 | 0 | 3 |
| RPL22 | ZFAS1 | 0.678927 | 4 | 0 | 3 |
| RPL22 | RPL21 | 0.674954 | 4 | 0 | 3 |
| RPL22 | KIAA2013 | 0.656038 | 3 | 0 | 3 |
| RPL22 | RPL12 | 0.65602 | 4 | 0 | 3 |
| RPL22 | TMEM131 | 0.643937 | 3 | 0 | 3 |
| RPL22 | WDR83OS | 0.621418 | 4 | 0 | 3 |
| RPL22 | WRAP73 | 0.616896 | 7 | 0 | 5 |
| RPL22 | ARL6IP4 | 0.611228 | 4 | 0 | 3 |
| RPL22 | DDX49 | 0.610685 | 4 | 0 | 3 |
| RPL22 | RPL31 | 0.607087 | 8 | 0 | 6 |
| RPL22 | RPS12 | 0.605093 | 7 | 0 | 5 |
| RPL22 | EIF4B | 0.604248 | 6 | 0 | 5 |
| RPL22 | ADPRM | 0.604132 | 4 | 0 | 3 |
| RPL22 | GPC2 | 0.601174 | 3 | 0 | 3 |
| RPL22 | FRA10AC1 | 0.595905 | 5 | 0 | 4 |
| RPL22 | ACTR10 | 0.593858 | 4 | 0 | 3 |
| RPL22 | RPL37 | 0.591913 | 8 | 0 | 6 |
For details and further investigation, click here
