| Full name: DEAD-box helicase 49 | Alias Symbol: FLJ10432|Dbp8 | ||
| Type: protein-coding gene | Cytoband: 19p13.11 | ||
| Entrez ID: 54555 | HGNC ID: HGNC:18684 | Ensembl Gene: ENSG00000105671 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of DDX49:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DDX49 | 54555 | 31807_at | 0.3517 | 0.4961 | |
| GSE20347 | DDX49 | 54555 | 31807_at | 0.0829 | 0.4125 | |
| GSE23400 | DDX49 | 54555 | 31807_at | -0.0276 | 0.4241 | |
| GSE26886 | DDX49 | 54555 | 31807_at | 0.4062 | 0.0195 | |
| GSE29001 | DDX49 | 54555 | 31807_at | 0.2063 | 0.3209 | |
| GSE38129 | DDX49 | 54555 | 31807_at | 0.2171 | 0.0124 | |
| GSE45670 | DDX49 | 54555 | 31807_at | 0.1872 | 0.0440 | |
| GSE53622 | DDX49 | 54555 | 153586 | 0.1686 | 0.0014 | |
| GSE53624 | DDX49 | 54555 | 153586 | -0.0114 | 0.8597 | |
| GSE63941 | DDX49 | 54555 | 31807_at | 0.0930 | 0.7957 | |
| GSE77861 | DDX49 | 54555 | 31807_at | 0.0966 | 0.5405 | |
| GSE97050 | DDX49 | 54555 | A_23_P16573 | -0.5685 | 0.3791 | |
| SRP007169 | DDX49 | 54555 | RNAseq | -0.2021 | 0.5262 | |
| SRP008496 | DDX49 | 54555 | RNAseq | -0.4666 | 0.0297 | |
| SRP064894 | DDX49 | 54555 | RNAseq | 0.6913 | 0.0214 | |
| SRP133303 | DDX49 | 54555 | RNAseq | 0.2968 | 0.0961 | |
| SRP159526 | DDX49 | 54555 | RNAseq | 0.3600 | 0.0404 | |
| SRP193095 | DDX49 | 54555 | RNAseq | 0.2338 | 0.0173 | |
| SRP219564 | DDX49 | 54555 | RNAseq | 0.4418 | 0.1635 | |
| TCGA | DDX49 | 54555 | RNAseq | 0.2544 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by DDX49 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DDX49:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DDX49 | 54555 | 4 | 5 | 21 | |
| GSE20123 | DDX49 | 54555 | 3 | 3 | 24 | |
| GSE43470 | DDX49 | 54555 | 2 | 5 | 36 | |
| GSE46452 | DDX49 | 54555 | 47 | 1 | 11 | |
| GSE47630 | DDX49 | 54555 | 5 | 8 | 27 | |
| GSE54993 | DDX49 | 54555 | 16 | 4 | 50 | |
| GSE54994 | DDX49 | 54555 | 6 | 13 | 34 | |
| GSE60625 | DDX49 | 54555 | 9 | 0 | 2 | |
| GSE74703 | DDX49 | 54555 | 2 | 3 | 31 | |
| GSE74704 | DDX49 | 54555 | 0 | 3 | 17 | |
| TCGA | DDX49 | 54555 | 16 | 10 | 70 |
Total number of gains: 110; Total number of losses: 55; Total Number of normals: 323.
Somatic mutations of DDX49:
Generating mutation plots.
Highly correlated genes for DDX49:
Showing top 20/195 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DDX49 | PRR15 | 0.783273 | 4 | 0 | 4 |
| DDX49 | TRPM2 | 0.729624 | 3 | 0 | 3 |
| DDX49 | ZNF526 | 0.715226 | 3 | 0 | 3 |
| DDX49 | RCOR2 | 0.706239 | 3 | 0 | 3 |
| DDX49 | ZFAT | 0.705957 | 3 | 0 | 3 |
| DDX49 | ARL8A | 0.689707 | 3 | 0 | 3 |
| DDX49 | C19orf53 | 0.689705 | 9 | 0 | 7 |
| DDX49 | ZNF620 | 0.686726 | 3 | 0 | 3 |
| DDX49 | THAP3 | 0.686392 | 3 | 0 | 3 |
| DDX49 | HPS1 | 0.684314 | 3 | 0 | 3 |
| DDX49 | ATG101 | 0.68402 | 3 | 0 | 3 |
| DDX49 | SETD1B | 0.679697 | 3 | 0 | 3 |
| DDX49 | NUBP1 | 0.677397 | 3 | 0 | 3 |
| DDX49 | ALKBH2 | 0.672834 | 4 | 0 | 3 |
| DDX49 | FAM24B | 0.661415 | 4 | 0 | 3 |
| DDX49 | WDR90 | 0.653815 | 4 | 0 | 3 |
| DDX49 | SIX2 | 0.651847 | 5 | 0 | 4 |
| DDX49 | PCP2 | 0.650653 | 3 | 0 | 3 |
| DDX49 | TMEM63A | 0.650318 | 3 | 0 | 3 |
| DDX49 | FOXJ1 | 0.634838 | 4 | 0 | 3 |
For details and further investigation, click here
