| Full name: otopetrin 3 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 17q25.1 | ||
| Entrez ID: 347741 | HGNC ID: HGNC:19658 | Ensembl Gene: ENSG00000182938 | OMIM ID: 607828 |
| Drug and gene relationship at DGIdb | |||
Expression of OTOP3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE53622 | OTOP3 | 347741 | 39495 | -2.3987 | 0.0000 | |
| GSE53624 | OTOP3 | 347741 | 39495 | -2.6042 | 0.0000 | |
| GSE97050 | OTOP3 | 347741 | A_23_P365201 | -0.5815 | 0.3192 | |
| SRP007169 | OTOP3 | 347741 | RNAseq | -0.4654 | 0.8234 | |
| SRP008496 | OTOP3 | 347741 | RNAseq | -1.1604 | 0.4006 | |
| SRP064894 | OTOP3 | 347741 | RNAseq | -4.2011 | 0.0000 | |
| SRP133303 | OTOP3 | 347741 | RNAseq | -3.1248 | 0.0000 | |
| SRP159526 | OTOP3 | 347741 | RNAseq | -1.2673 | 0.1906 | |
| SRP193095 | OTOP3 | 347741 | RNAseq | -3.0683 | 0.0000 | |
| TCGA | OTOP3 | 347741 | RNAseq | 0.1051 | 0.8946 |
Upregulated datasets: 0; Downregulated datasets: 5.
Survival by OTOP3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of OTOP3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | OTOP3 | 347741 | 6 | 2 | 22 | |
| GSE20123 | OTOP3 | 347741 | 6 | 2 | 22 | |
| GSE43470 | OTOP3 | 347741 | 5 | 3 | 35 | |
| GSE46452 | OTOP3 | 347741 | 33 | 0 | 26 | |
| GSE47630 | OTOP3 | 347741 | 8 | 1 | 31 | |
| GSE54993 | OTOP3 | 347741 | 2 | 5 | 63 | |
| GSE54994 | OTOP3 | 347741 | 10 | 4 | 39 | |
| GSE60625 | OTOP3 | 347741 | 6 | 0 | 5 | |
| GSE74703 | OTOP3 | 347741 | 5 | 1 | 30 | |
| GSE74704 | OTOP3 | 347741 | 4 | 1 | 15 | |
| TCGA | OTOP3 | 347741 | 32 | 10 | 54 |
Total number of gains: 117; Total number of losses: 29; Total Number of normals: 342.
Somatic mutations of OTOP3:
Generating mutation plots.
Highly correlated genes for OTOP3:
Showing top 20/383 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| OTOP3 | PRSS27 | 0.872729 | 3 | 0 | 3 |
| OTOP3 | SCEL | 0.865321 | 3 | 0 | 3 |
| OTOP3 | CEACAM1 | 0.8614 | 3 | 0 | 3 |
| OTOP3 | NCCRP1 | 0.861326 | 3 | 0 | 3 |
| OTOP3 | CEACAM7 | 0.858897 | 3 | 0 | 3 |
| OTOP3 | CEACAM5 | 0.857727 | 3 | 0 | 3 |
| OTOP3 | SPATA19 | 0.856347 | 3 | 0 | 3 |
| OTOP3 | CEACAM3 | 0.855589 | 3 | 0 | 3 |
| OTOP3 | EPS8L2 | 0.854162 | 3 | 0 | 3 |
| OTOP3 | DEGS2 | 0.848661 | 3 | 0 | 3 |
| OTOP3 | SLURP1 | 0.845414 | 3 | 0 | 3 |
| OTOP3 | NCR1 | 0.843844 | 3 | 0 | 3 |
| OTOP3 | SPINK7 | 0.843809 | 3 | 0 | 3 |
| OTOP3 | VSIG10L | 0.843284 | 3 | 0 | 3 |
| OTOP3 | RAET1E | 0.840826 | 3 | 0 | 3 |
| OTOP3 | TMPRSS11A | 0.839745 | 3 | 0 | 3 |
| OTOP3 | IL36A | 0.83627 | 3 | 0 | 3 |
| OTOP3 | APOA1 | 0.835334 | 3 | 0 | 3 |
| OTOP3 | CNFN | 0.834337 | 3 | 0 | 3 |
| OTOP3 | RHCG | 0.832571 | 3 | 0 | 3 |
For details and further investigation, click here
