| Full name: sphingosine-1-phosphate receptor 4 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 19p13.3 | ||
| Entrez ID: 8698 | HGNC ID: HGNC:3170 | Ensembl Gene: ENSG00000125910 | OMIM ID: 603751 |
| Drug and gene relationship at DGIdb | |||
S1PR4 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04068 | FoxO signaling pathway | |
| hsa04071 | Sphingolipid signaling pathway |
Expression of S1PR4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | S1PR4 | 8698 | 206437_at | 0.1305 | 0.6766 | |
| GSE20347 | S1PR4 | 8698 | 206437_at | 0.0270 | 0.7576 | |
| GSE23400 | S1PR4 | 8698 | 206437_at | -0.0677 | 0.0645 | |
| GSE26886 | S1PR4 | 8698 | 206437_at | 0.2755 | 0.0251 | |
| GSE29001 | S1PR4 | 8698 | 206437_at | -0.0994 | 0.5876 | |
| GSE38129 | S1PR4 | 8698 | 206437_at | -0.0920 | 0.3850 | |
| GSE45670 | S1PR4 | 8698 | 206437_at | 0.0414 | 0.6511 | |
| GSE53622 | S1PR4 | 8698 | 115115 | -0.0822 | 0.2549 | |
| GSE53624 | S1PR4 | 8698 | 115115 | -0.4977 | 0.0000 | |
| GSE63941 | S1PR4 | 8698 | 206437_at | 0.1180 | 0.4408 | |
| GSE77861 | S1PR4 | 8698 | 206437_at | -0.0252 | 0.8658 | |
| GSE97050 | S1PR4 | 8698 | A_33_P3281273 | 0.0754 | 0.7546 | |
| SRP064894 | S1PR4 | 8698 | RNAseq | 0.2071 | 0.6385 | |
| SRP133303 | S1PR4 | 8698 | RNAseq | -0.4248 | 0.1955 | |
| SRP159526 | S1PR4 | 8698 | RNAseq | -1.4081 | 0.1694 | |
| SRP219564 | S1PR4 | 8698 | RNAseq | 0.5725 | 0.1669 | |
| TCGA | S1PR4 | 8698 | RNAseq | -0.3093 | 0.2068 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by S1PR4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of S1PR4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | S1PR4 | 8698 | 4 | 4 | 22 | |
| GSE20123 | S1PR4 | 8698 | 3 | 4 | 23 | |
| GSE43470 | S1PR4 | 8698 | 1 | 9 | 33 | |
| GSE46452 | S1PR4 | 8698 | 47 | 1 | 11 | |
| GSE47630 | S1PR4 | 8698 | 5 | 7 | 28 | |
| GSE54993 | S1PR4 | 8698 | 16 | 3 | 51 | |
| GSE54994 | S1PR4 | 8698 | 8 | 16 | 29 | |
| GSE60625 | S1PR4 | 8698 | 9 | 0 | 2 | |
| GSE74703 | S1PR4 | 8698 | 1 | 6 | 29 | |
| GSE74704 | S1PR4 | 8698 | 1 | 3 | 16 | |
| TCGA | S1PR4 | 8698 | 8 | 22 | 66 |
Total number of gains: 103; Total number of losses: 75; Total Number of normals: 310.
Somatic mutations of S1PR4:
Generating mutation plots.
Highly correlated genes for S1PR4:
Showing top 20/885 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| S1PR4 | MYO15B | 0.767385 | 3 | 0 | 3 |
| S1PR4 | ABCA4 | 0.761196 | 4 | 0 | 4 |
| S1PR4 | SIGLEC7 | 0.756457 | 8 | 0 | 7 |
| S1PR4 | TSPAN10 | 0.7424 | 3 | 0 | 3 |
| S1PR4 | C14orf180 | 0.741492 | 3 | 0 | 3 |
| S1PR4 | HK3 | 0.726681 | 4 | 0 | 4 |
| S1PR4 | TSPAN11 | 0.726671 | 4 | 0 | 4 |
| S1PR4 | CFC1 | 0.726503 | 3 | 0 | 3 |
| S1PR4 | CELF5 | 0.72231 | 3 | 0 | 3 |
| S1PR4 | TDGF1 | 0.72079 | 3 | 0 | 3 |
| S1PR4 | HAGHL | 0.716462 | 4 | 0 | 3 |
| S1PR4 | ZFPM1 | 0.714148 | 4 | 0 | 4 |
| S1PR4 | C19orf81 | 0.712291 | 3 | 0 | 3 |
| S1PR4 | FES | 0.71162 | 3 | 0 | 3 |
| S1PR4 | TBC1D10C | 0.70857 | 3 | 0 | 3 |
| S1PR4 | CALML6 | 0.706826 | 3 | 0 | 3 |
| S1PR4 | KIRREL2 | 0.704855 | 5 | 0 | 5 |
| S1PR4 | YY2 | 0.702671 | 3 | 0 | 3 |
| S1PR4 | PABPN1L | 0.69843 | 3 | 0 | 3 |
| S1PR4 | C11orf94 | 0.697862 | 3 | 0 | 3 |
For details and further investigation, click here
