| Full name: sialic acid binding Ig like lectin 7 | Alias Symbol: SIGLEC-7|p75/AIRM1|QA79|CD328 | ||
| Type: protein-coding gene | Cytoband: 19q13.41 | ||
| Entrez ID: 27036 | HGNC ID: HGNC:10876 | Ensembl Gene: ENSG00000168995 | OMIM ID: 604410 |
| Drug and gene relationship at DGIdb | |||
Expression of SIGLEC7:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SIGLEC7 | 27036 | 216537_s_at | 0.0845 | 0.7308 | |
| GSE20347 | SIGLEC7 | 27036 | 216537_s_at | -0.0435 | 0.5355 | |
| GSE23400 | SIGLEC7 | 27036 | 217159_x_at | -0.0743 | 0.0821 | |
| GSE26886 | SIGLEC7 | 27036 | 216537_s_at | 0.0878 | 0.4760 | |
| GSE29001 | SIGLEC7 | 27036 | 216537_s_at | -0.1136 | 0.4494 | |
| GSE38129 | SIGLEC7 | 27036 | 216537_s_at | -0.1009 | 0.1815 | |
| GSE45670 | SIGLEC7 | 27036 | 216537_s_at | 0.0812 | 0.2874 | |
| GSE53622 | SIGLEC7 | 27036 | 80342 | 0.2039 | 0.0009 | |
| GSE53624 | SIGLEC7 | 27036 | 80342 | 0.3231 | 0.0000 | |
| GSE63941 | SIGLEC7 | 27036 | 216537_s_at | 0.1946 | 0.1163 | |
| GSE77861 | SIGLEC7 | 27036 | 216537_s_at | -0.0614 | 0.6051 | |
| GSE97050 | SIGLEC7 | 27036 | A_23_P38784 | 0.2202 | 0.3977 | |
| SRP064894 | SIGLEC7 | 27036 | RNAseq | 2.1412 | 0.0000 | |
| SRP133303 | SIGLEC7 | 27036 | RNAseq | 1.3303 | 0.0005 | |
| SRP159526 | SIGLEC7 | 27036 | RNAseq | 0.6420 | 0.3290 | |
| SRP219564 | SIGLEC7 | 27036 | RNAseq | 1.9669 | 0.0023 | |
| TCGA | SIGLEC7 | 27036 | RNAseq | 1.4952 | 0.0000 |
Upregulated datasets: 4; Downregulated datasets: 0.
Survival by SIGLEC7 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SIGLEC7:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SIGLEC7 | 27036 | 3 | 4 | 23 | |
| GSE20123 | SIGLEC7 | 27036 | 3 | 3 | 24 | |
| GSE43470 | SIGLEC7 | 27036 | 4 | 11 | 28 | |
| GSE46452 | SIGLEC7 | 27036 | 45 | 1 | 13 | |
| GSE47630 | SIGLEC7 | 27036 | 9 | 6 | 25 | |
| GSE54993 | SIGLEC7 | 27036 | 17 | 4 | 49 | |
| GSE54994 | SIGLEC7 | 27036 | 4 | 14 | 35 | |
| GSE60625 | SIGLEC7 | 27036 | 9 | 0 | 2 | |
| GSE74703 | SIGLEC7 | 27036 | 4 | 7 | 25 | |
| GSE74704 | SIGLEC7 | 27036 | 3 | 1 | 16 | |
| TCGA | SIGLEC7 | 27036 | 14 | 19 | 63 |
Total number of gains: 115; Total number of losses: 70; Total Number of normals: 303.
Somatic mutations of SIGLEC7:
Generating mutation plots.
Highly correlated genes for SIGLEC7:
Showing top 20/1127 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SIGLEC7 | PALM3 | 0.831259 | 3 | 0 | 3 |
| SIGLEC7 | POM121L12 | 0.804768 | 3 | 0 | 3 |
| SIGLEC7 | CFC1 | 0.784072 | 3 | 0 | 3 |
| SIGLEC7 | SLC10A1 | 0.776661 | 5 | 0 | 5 |
| SIGLEC7 | S1PR4 | 0.756457 | 8 | 0 | 7 |
| SIGLEC7 | ABCC6 | 0.747329 | 3 | 0 | 3 |
| SIGLEC7 | PNLIPRP1 | 0.74088 | 6 | 0 | 6 |
| SIGLEC7 | C9orf131 | 0.737494 | 3 | 0 | 3 |
| SIGLEC7 | CD247 | 0.734253 | 4 | 0 | 3 |
| SIGLEC7 | HOXB6 | 0.728977 | 3 | 0 | 3 |
| SIGLEC7 | OR4E2 | 0.727631 | 3 | 0 | 3 |
| SIGLEC7 | FAM178B | 0.726517 | 4 | 0 | 3 |
| SIGLEC7 | TMEM221 | 0.717816 | 3 | 0 | 3 |
| SIGLEC7 | PEX11G | 0.714687 | 3 | 0 | 3 |
| SIGLEC7 | APOL4 | 0.714245 | 4 | 0 | 3 |
| SIGLEC7 | SPINT3 | 0.714159 | 5 | 0 | 5 |
| SIGLEC7 | OR2C1 | 0.713359 | 6 | 0 | 6 |
| SIGLEC7 | ACR | 0.711169 | 7 | 0 | 6 |
| SIGLEC7 | MMP19 | 0.710371 | 8 | 0 | 6 |
| SIGLEC7 | CNTD2 | 0.709215 | 9 | 0 | 8 |
For details and further investigation, click here
