CALML6

 

Full name: calmodulin like 6 Alias Symbol: CAGLP
Type: protein-coding gene Cytoband: 1p36.33
Entrez ID: 163688 HGNC ID: HGNC:24193 Ensembl Gene: ENSG00000169885 OMIM ID: 610171
Drug and gene relationship at DGIdb

 

CALML6 involved pathways:

KEGG pathway Description View
hsa04014Ras signaling pathway
hsa04015Rap1 signaling pathway
hsa04020Calcium signaling pathway
hsa04022cGMP-PKG signaling pathway
hsa04024cAMP signaling pathway
hsa04114Oocyte meiosis
hsa04261Adrenergic signaling in cardiomyocytes
hsa04270Vascular smooth muscle contraction
hsa04713Circadian entrainment
hsa04720Long-term potentiation
hsa04722Neurotrophin signaling pathway
hsa04728Dopaminergic synapse
hsa04740Olfactory transduction
hsa04750Inflammatory mediator regulation of TRP channels
hsa04910Insulin signaling pathway
hsa04912GnRH signaling pathway
hsa04915Estrogen signaling pathway
hsa04916Melanogenesis
hsa04921Oxytocin signaling pathway
hsa04922Glucagon signaling pathway
hsa04924Renin secretion
hsa04925Aldosterone synthesis and secretion
hsa04970Salivary secretion
hsa04971Gastric acid secretion
hsa05010Alzheimer's disease
hsa05031Amphetamine addiction
hsa05034Alcoholism
hsa05152Tuberculosis
hsa05214Glioma

 

Expression of CALML6:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 CALML6 163688 1552402_at 0.0810 0.6907
GSE26886 CALML6 163688 1552402_at -0.0236 0.8932
GSE45670 CALML6 163688 1552402_at -0.0025 0.9809
GSE53622 CALML6 163688 51336 0.1723 0.0148
GSE53624 CALML6 163688 51336 0.2662 0.0024
GSE63941 CALML6 163688 1552402_at 0.1513 0.3932
GSE77861 CALML6 163688 1552402_at 0.0245 0.8275
GSE97050 CALML6 163688 A_23_P62588 -0.0126 0.9615
TCGA CALML6 163688 RNAseq 0.8744 0.2360

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by CALML6 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of CALML6:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 CALML6 163688 4 7 19
GSE20123 CALML6 163688 4 6 20
GSE43470 CALML6 163688 3 5 35
GSE46452 CALML6 163688 7 1 51
GSE47630 CALML6 163688 8 4 28
GSE54993 CALML6 163688 2 2 66
GSE54994 CALML6 163688 15 2 36
GSE60625 CALML6 163688 0 0 11
GSE74703 CALML6 163688 3 3 30
GSE74704 CALML6 163688 4 0 16
TCGA CALML6 163688 14 20 62

Total number of gains: 64; Total number of losses: 50; Total Number of normals: 374.  

 

Somatic mutations of CALML6:

 

Generating mutation plots.

 

Highly correlated genes for CALML6:

 

Showing top 20/275 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
CALML6MOS0.776387303
CALML6KCNJ130.775148303
CALML6C19orf710.755634303
CALML6OR2T10.751179303
CALML6HAP10.748972303
CALML6CFC10.747662303
CALML6CRYGA0.744691303
CALML6FFAR10.742139403
CALML6KRT770.734218303
CALML6GPR880.733309303
CALML6THPO0.73176303
CALML6TCTE10.729833303
CALML6GHRHR0.729688505
CALML6C20orf1410.729478303
CALML6IQCH0.72862303
CALML6GPR1500.726966303
CALML6C2CD4D0.725279303
CALML6MRGPRG0.724857303
CALML6ATCAY0.724191403
CALML6KATNAL20.717689303

For details and further investigation, click here