| Full name: teratocarcinoma-derived growth factor 1 | Alias Symbol: CRIPTO|CR|Cripto-1|CR-1 | ||
| Type: protein-coding gene | Cytoband: 3p21.31 | ||
| Entrez ID: 6997 | HGNC ID: HGNC:11701 | Ensembl Gene: ENSG00000241186 | OMIM ID: 187395 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of TDGF1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE53622 | TDGF1 | 6997 | 85434 | -0.4796 | 0.0000 | |
| GSE53624 | TDGF1 | 6997 | 85434 | -0.6426 | 0.0000 | |
| GSE97050 | TDGF1 | 6997 | A_23_P366376 | -0.2088 | 0.3961 | |
| SRP133303 | TDGF1 | 6997 | RNAseq | -0.2078 | 0.2883 | |
| SRP193095 | TDGF1 | 6997 | RNAseq | -0.1775 | 0.3063 | |
| TCGA | TDGF1 | 6997 | RNAseq | -4.1577 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by TDGF1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TDGF1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TDGF1 | 6997 | 0 | 17 | 13 | |
| GSE20123 | TDGF1 | 6997 | 0 | 18 | 12 | |
| GSE43470 | TDGF1 | 6997 | 0 | 19 | 24 | |
| GSE46452 | TDGF1 | 6997 | 2 | 17 | 40 | |
| GSE47630 | TDGF1 | 6997 | 2 | 23 | 15 | |
| GSE54993 | TDGF1 | 6997 | 7 | 2 | 61 | |
| GSE54994 | TDGF1 | 6997 | 0 | 36 | 17 | |
| GSE60625 | TDGF1 | 6997 | 5 | 0 | 6 | |
| GSE74703 | TDGF1 | 6997 | 0 | 15 | 21 | |
| GSE74704 | TDGF1 | 6997 | 0 | 12 | 8 | |
| TCGA | TDGF1 | 6997 | 1 | 75 | 20 |
Total number of gains: 17; Total number of losses: 234; Total Number of normals: 237.
Somatic mutations of TDGF1:
Generating mutation plots.
Highly correlated genes for TDGF1:
Showing top 20/111 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TDGF1 | GPT | 0.796034 | 3 | 0 | 3 |
| TDGF1 | PRDM16 | 0.792708 | 3 | 0 | 3 |
| TDGF1 | HTR3A | 0.790476 | 3 | 0 | 3 |
| TDGF1 | KRTAP6-1 | 0.782921 | 3 | 0 | 3 |
| TDGF1 | SCARA5 | 0.782263 | 3 | 0 | 3 |
| TDGF1 | BEST4 | 0.782133 | 3 | 0 | 3 |
| TDGF1 | FOXA3 | 0.773807 | 3 | 0 | 3 |
| TDGF1 | MAP3K10 | 0.773465 | 3 | 0 | 3 |
| TDGF1 | SCNN1D | 0.771698 | 3 | 0 | 3 |
| TDGF1 | TNR | 0.768926 | 3 | 0 | 3 |
| TDGF1 | IL17RE | 0.765271 | 3 | 0 | 3 |
| TDGF1 | RAB40B | 0.760804 | 3 | 0 | 3 |
| TDGF1 | DNAJB8 | 0.752652 | 3 | 0 | 3 |
| TDGF1 | KRTAP19-1 | 0.75152 | 3 | 0 | 3 |
| TDGF1 | USH1C | 0.750832 | 3 | 0 | 3 |
| TDGF1 | GDF7 | 0.750334 | 3 | 0 | 3 |
| TDGF1 | KCNJ13 | 0.748234 | 3 | 0 | 3 |
| TDGF1 | CHRND | 0.742706 | 3 | 0 | 3 |
| TDGF1 | SRPK3 | 0.742014 | 3 | 0 | 3 |
| TDGF1 | KIRREL2 | 0.741877 | 3 | 0 | 3 |
For details and further investigation, click here
