| Full name: sirtuin 3 | Alias Symbol: SIR2L3 | ||
| Type: protein-coding gene | Cytoband: 11p15.5 | ||
| Entrez ID: 23410 | HGNC ID: HGNC:14931 | Ensembl Gene: ENSG00000142082 | OMIM ID: 604481 |
| Drug and gene relationship at DGIdb | |||
Expression of SIRT3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SIRT3 | 23410 | 49327_at | -0.0791 | 0.7041 | |
| GSE20347 | SIRT3 | 23410 | 49327_at | 0.0113 | 0.9395 | |
| GSE23400 | SIRT3 | 23410 | 49327_at | -0.0364 | 0.3191 | |
| GSE26886 | SIRT3 | 23410 | 49327_at | -0.2368 | 0.1054 | |
| GSE29001 | SIRT3 | 23410 | 49327_at | -0.1080 | 0.5369 | |
| GSE38129 | SIRT3 | 23410 | 49327_at | -0.1496 | 0.0679 | |
| GSE45670 | SIRT3 | 23410 | 49327_at | 0.0855 | 0.2982 | |
| GSE53622 | SIRT3 | 23410 | 30607 | -0.0188 | 0.8223 | |
| GSE53624 | SIRT3 | 23410 | 85524 | 0.1884 | 0.0039 | |
| GSE63941 | SIRT3 | 23410 | 49327_at | 0.4942 | 0.0421 | |
| GSE77861 | SIRT3 | 23410 | 49327_at | 0.0013 | 0.9883 | |
| GSE97050 | SIRT3 | 23410 | A_24_P85158 | -0.1121 | 0.6674 | |
| SRP007169 | SIRT3 | 23410 | RNAseq | -0.4931 | 0.3011 | |
| SRP008496 | SIRT3 | 23410 | RNAseq | -0.1940 | 0.5609 | |
| SRP064894 | SIRT3 | 23410 | RNAseq | 0.1632 | 0.4116 | |
| SRP133303 | SIRT3 | 23410 | RNAseq | -0.1644 | 0.3073 | |
| SRP159526 | SIRT3 | 23410 | RNAseq | -0.2034 | 0.4245 | |
| SRP193095 | SIRT3 | 23410 | RNAseq | 0.1415 | 0.1429 | |
| SRP219564 | SIRT3 | 23410 | RNAseq | 0.2534 | 0.4287 | |
| TCGA | SIRT3 | 23410 | RNAseq | -0.0621 | 0.2715 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SIRT3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SIRT3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SIRT3 | 23410 | 1 | 11 | 18 | |
| GSE20123 | SIRT3 | 23410 | 1 | 12 | 17 | |
| GSE43470 | SIRT3 | 23410 | 1 | 11 | 31 | |
| GSE46452 | SIRT3 | 23410 | 7 | 8 | 44 | |
| GSE47630 | SIRT3 | 23410 | 4 | 12 | 24 | |
| GSE54993 | SIRT3 | 23410 | 3 | 2 | 65 | |
| GSE54994 | SIRT3 | 23410 | 1 | 12 | 40 | |
| GSE60625 | SIRT3 | 23410 | 0 | 0 | 11 | |
| GSE74703 | SIRT3 | 23410 | 1 | 9 | 26 | |
| GSE74704 | SIRT3 | 23410 | 0 | 8 | 12 | |
| TCGA | SIRT3 | 23410 | 8 | 38 | 50 |
Total number of gains: 27; Total number of losses: 123; Total Number of normals: 338.
Somatic mutations of SIRT3:
Generating mutation plots.
Highly correlated genes for SIRT3:
Showing top 20/966 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SIRT3 | SERPINA5 | 0.707598 | 5 | 0 | 5 |
| SIRT3 | DNAAF1 | 0.705045 | 4 | 0 | 4 |
| SIRT3 | MAML3 | 0.704296 | 4 | 0 | 4 |
| SIRT3 | CAMK2B | 0.701686 | 8 | 0 | 7 |
| SIRT3 | LGI4 | 0.700649 | 3 | 0 | 3 |
| SIRT3 | VWA8-AS1 | 0.696331 | 3 | 0 | 3 |
| SIRT3 | FOXN3-AS2 | 0.691721 | 5 | 0 | 5 |
| SIRT3 | LALBA | 0.691139 | 4 | 0 | 4 |
| SIRT3 | TBXA2R | 0.690287 | 5 | 0 | 4 |
| SIRT3 | SCGB1D1 | 0.6888 | 3 | 0 | 3 |
| SIRT3 | CGA | 0.685643 | 5 | 0 | 5 |
| SIRT3 | NPTXR | 0.678377 | 5 | 0 | 5 |
| SIRT3 | OR2J2 | 0.675941 | 3 | 0 | 3 |
| SIRT3 | LINC00950 | 0.675755 | 6 | 0 | 6 |
| SIRT3 | PRODH2 | 0.674922 | 9 | 0 | 8 |
| SIRT3 | MUC5AC | 0.673543 | 7 | 0 | 6 |
| SIRT3 | GPR15 | 0.672973 | 6 | 0 | 6 |
| SIRT3 | AKAP6 | 0.671134 | 7 | 0 | 6 |
| SIRT3 | GIP | 0.670793 | 3 | 0 | 3 |
| SIRT3 | NTNG1 | 0.669709 | 4 | 0 | 3 |
For details and further investigation, click here
