| Full name: mastermind like transcriptional coactivator 3 | Alias Symbol: KIAA1816|MAM2|CAGH3|GDN | ||
| Type: protein-coding gene | Cytoband: 4q31.1 | ||
| Entrez ID: 55534 | HGNC ID: HGNC:16272 | Ensembl Gene: ENSG00000196782 | OMIM ID: 608991 |
| Drug and gene relationship at DGIdb | |||
MAML3 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04330 | Notch signaling pathway |
Expression of MAML3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MAML3 | 55534 | 242794_at | -1.7094 | 0.0632 | |
| GSE20347 | MAML3 | 55534 | 207946_at | -0.1256 | 0.0207 | |
| GSE23400 | MAML3 | 55534 | 207946_at | -0.1380 | 0.0028 | |
| GSE26886 | MAML3 | 55534 | 242794_at | -1.7177 | 0.0001 | |
| GSE29001 | MAML3 | 55534 | 207946_at | -0.2151 | 0.1483 | |
| GSE38129 | MAML3 | 55534 | 207946_at | -0.1093 | 0.0402 | |
| GSE45670 | MAML3 | 55534 | 242794_at | -1.1567 | 0.0019 | |
| GSE53622 | MAML3 | 55534 | 6342 | 0.0152 | 0.8414 | |
| GSE53624 | MAML3 | 55534 | 6342 | 0.0040 | 0.9650 | |
| GSE63941 | MAML3 | 55534 | 228508_at | 0.3159 | 0.1291 | |
| GSE77861 | MAML3 | 55534 | 228508_at | -0.1405 | 0.2480 | |
| GSE97050 | MAML3 | 55534 | A_33_P3335371 | -0.1368 | 0.4936 | |
| SRP007169 | MAML3 | 55534 | RNAseq | -2.0282 | 0.0004 | |
| SRP008496 | MAML3 | 55534 | RNAseq | -1.8475 | 0.0000 | |
| SRP064894 | MAML3 | 55534 | RNAseq | -1.5761 | 0.0000 | |
| SRP133303 | MAML3 | 55534 | RNAseq | -1.6884 | 0.0000 | |
| SRP159526 | MAML3 | 55534 | RNAseq | -1.6223 | 0.0000 | |
| SRP193095 | MAML3 | 55534 | RNAseq | -1.1384 | 0.0000 | |
| SRP219564 | MAML3 | 55534 | RNAseq | -1.5227 | 0.0002 | |
| TCGA | MAML3 | 55534 | RNAseq | -0.3655 | 0.0004 |
Upregulated datasets: 0; Downregulated datasets: 9.
Survival by MAML3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MAML3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MAML3 | 55534 | 0 | 14 | 16 | |
| GSE20123 | MAML3 | 55534 | 0 | 14 | 16 | |
| GSE43470 | MAML3 | 55534 | 0 | 13 | 30 | |
| GSE46452 | MAML3 | 55534 | 1 | 36 | 22 | |
| GSE47630 | MAML3 | 55534 | 0 | 22 | 18 | |
| GSE54993 | MAML3 | 55534 | 10 | 0 | 60 | |
| GSE54994 | MAML3 | 55534 | 2 | 11 | 40 | |
| GSE60625 | MAML3 | 55534 | 0 | 1 | 10 | |
| GSE74703 | MAML3 | 55534 | 0 | 11 | 25 | |
| GSE74704 | MAML3 | 55534 | 0 | 7 | 13 | |
| TCGA | MAML3 | 55534 | 12 | 31 | 53 |
Total number of gains: 25; Total number of losses: 160; Total Number of normals: 303.
Somatic mutations of MAML3:
Generating mutation plots.
Highly correlated genes for MAML3:
Showing top 20/847 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MAML3 | FAR1 | 0.781532 | 3 | 0 | 3 |
| MAML3 | FAM3D | 0.767347 | 4 | 0 | 4 |
| MAML3 | FAM214A | 0.764853 | 4 | 0 | 4 |
| MAML3 | SOCS6 | 0.749549 | 3 | 0 | 3 |
| MAML3 | A2ML1 | 0.748435 | 4 | 0 | 4 |
| MAML3 | ROBO2 | 0.743909 | 3 | 0 | 3 |
| MAML3 | KRT78 | 0.73678 | 4 | 0 | 3 |
| MAML3 | KATNBL1 | 0.735704 | 3 | 0 | 3 |
| MAML3 | SLTM | 0.73559 | 4 | 0 | 3 |
| MAML3 | VSIG2 | 0.730762 | 4 | 0 | 4 |
| MAML3 | HCG22 | 0.72863 | 4 | 0 | 4 |
| MAML3 | CBR3-AS1 | 0.728451 | 3 | 0 | 3 |
| MAML3 | ZNF770 | 0.728165 | 3 | 0 | 3 |
| MAML3 | WDR64 | 0.726199 | 3 | 0 | 3 |
| MAML3 | BRK1 | 0.725477 | 4 | 0 | 4 |
| MAML3 | SH3BGRL2 | 0.72189 | 4 | 0 | 3 |
| MAML3 | FAM219B | 0.721291 | 3 | 0 | 3 |
| MAML3 | SAMD5 | 0.720408 | 4 | 0 | 3 |
| MAML3 | PRSS27 | 0.72038 | 4 | 0 | 3 |
| MAML3 | CAPN14 | 0.718883 | 4 | 0 | 3 |
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