| Full name: glycoprotein hormones, alpha polypeptide | Alias Symbol: HCG|GPHa|GPHA1|FSHA|LHA|TSHA|GPA1 | ||
| Type: protein-coding gene | Cytoband: 6q14.3 | ||
| Entrez ID: 1081 | HGNC ID: HGNC:1885 | Ensembl Gene: ENSG00000135346 | OMIM ID: 118850 |
| Drug and gene relationship at DGIdb | |||
CGA involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04913 | Ovarian steroidogenesis | |
| hsa04917 | Prolactin signaling pathway | |
| hsa04918 | Thyroid hormone synthesis | |
| hsa04923 | Regulation of lipolysis in adipocytes |
Expression of CGA:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CGA | 1081 | 204637_at | 0.0660 | 0.8218 | |
| GSE20347 | CGA | 1081 | 204637_at | 0.0706 | 0.5006 | |
| GSE23400 | CGA | 1081 | 204637_at | -0.1750 | 0.0050 | |
| GSE26886 | CGA | 1081 | 204637_at | 0.1868 | 0.3094 | |
| GSE29001 | CGA | 1081 | 204637_at | -0.2055 | 0.3801 | |
| GSE38129 | CGA | 1081 | 204637_at | -0.1386 | 0.3069 | |
| GSE45670 | CGA | 1081 | 204637_at | 0.1100 | 0.2820 | |
| GSE53622 | CGA | 1081 | 35354 | 0.0439 | 0.7527 | |
| GSE53624 | CGA | 1081 | 35354 | 0.5433 | 0.0000 | |
| GSE63941 | CGA | 1081 | 204637_at | 0.5687 | 0.7209 | |
| GSE77861 | CGA | 1081 | 204637_at | -0.1005 | 0.4736 | |
| SRP133303 | CGA | 1081 | RNAseq | 0.0989 | 0.7641 | |
| TCGA | CGA | 1081 | RNAseq | -1.7619 | 0.2052 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by CGA expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CGA:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CGA | 1081 | 1 | 4 | 25 | |
| GSE20123 | CGA | 1081 | 1 | 3 | 26 | |
| GSE43470 | CGA | 1081 | 2 | 1 | 40 | |
| GSE46452 | CGA | 1081 | 2 | 11 | 46 | |
| GSE47630 | CGA | 1081 | 8 | 6 | 26 | |
| GSE54993 | CGA | 1081 | 3 | 2 | 65 | |
| GSE54994 | CGA | 1081 | 8 | 8 | 37 | |
| GSE60625 | CGA | 1081 | 0 | 1 | 10 | |
| GSE74703 | CGA | 1081 | 2 | 1 | 33 | |
| GSE74704 | CGA | 1081 | 0 | 2 | 18 | |
| TCGA | CGA | 1081 | 5 | 21 | 70 |
Total number of gains: 32; Total number of losses: 60; Total Number of normals: 396.
Somatic mutations of CGA:
Generating mutation plots.
Highly correlated genes for CGA:
Showing top 20/1082 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CGA | RBP4 | 0.8189 | 3 | 0 | 3 |
| CGA | HHLA1 | 0.785765 | 4 | 0 | 4 |
| CGA | IFNA17 | 0.779134 | 4 | 0 | 4 |
| CGA | GH2 | 0.770189 | 4 | 0 | 4 |
| CGA | ZMAT4 | 0.762102 | 3 | 0 | 3 |
| CGA | ASCL3 | 0.748554 | 4 | 0 | 4 |
| CGA | HLA-DOA | 0.746681 | 4 | 0 | 4 |
| CGA | CCIN | 0.745757 | 3 | 0 | 3 |
| CGA | FSHR | 0.744178 | 4 | 0 | 4 |
| CGA | IL1RAPL2 | 0.74358 | 7 | 0 | 6 |
| CGA | NCR2 | 0.743443 | 5 | 0 | 5 |
| CGA | OVGP1 | 0.741815 | 3 | 0 | 3 |
| CGA | TRPM3 | 0.741812 | 4 | 0 | 3 |
| CGA | ACSL6 | 0.739799 | 3 | 0 | 3 |
| CGA | AQP2 | 0.739655 | 5 | 0 | 5 |
| CGA | ATG10 | 0.739273 | 5 | 0 | 4 |
| CGA | TUB | 0.738266 | 4 | 0 | 4 |
| CGA | ZNF835 | 0.736695 | 3 | 0 | 3 |
| CGA | FSTL4 | 0.736387 | 6 | 0 | 6 |
| CGA | FGF5 | 0.735585 | 3 | 0 | 3 |
For details and further investigation, click here
