| Full name: A-kinase anchoring protein 6 | Alias Symbol: KIAA0311|mAKAP|AKAP100|PRKA6|ADAP6 | ||
| Type: protein-coding gene | Cytoband: 14q12 | ||
| Entrez ID: 9472 | HGNC ID: HGNC:376 | Ensembl Gene: ENSG00000151320 | OMIM ID: 604691 |
| Drug and gene relationship at DGIdb | |||
Expression of AKAP6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | AKAP6 | 9472 | 205359_at | -0.4250 | 0.4519 | |
| GSE20347 | AKAP6 | 9472 | 205359_at | -0.0330 | 0.7893 | |
| GSE23400 | AKAP6 | 9472 | 205359_at | -0.2552 | 0.0000 | |
| GSE26886 | AKAP6 | 9472 | 205359_at | -0.0398 | 0.7694 | |
| GSE29001 | AKAP6 | 9472 | 205359_at | -0.1785 | 0.4361 | |
| GSE38129 | AKAP6 | 9472 | 205359_at | -0.3486 | 0.0006 | |
| GSE45670 | AKAP6 | 9472 | 217669_s_at | -0.0646 | 0.5147 | |
| GSE53622 | AKAP6 | 9472 | 32294 | -1.4166 | 0.0000 | |
| GSE53624 | AKAP6 | 9472 | 32294 | -1.4075 | 0.0000 | |
| GSE63941 | AKAP6 | 9472 | 217669_s_at | 0.2802 | 0.1779 | |
| GSE77861 | AKAP6 | 9472 | 205359_at | 0.0366 | 0.6561 | |
| GSE97050 | AKAP6 | 9472 | A_23_P14351 | -1.1482 | 0.1318 | |
| SRP007169 | AKAP6 | 9472 | RNAseq | -1.7565 | 0.0007 | |
| SRP064894 | AKAP6 | 9472 | RNAseq | -1.0201 | 0.0050 | |
| SRP133303 | AKAP6 | 9472 | RNAseq | -0.9223 | 0.0695 | |
| SRP159526 | AKAP6 | 9472 | RNAseq | -0.7634 | 0.2103 | |
| SRP193095 | AKAP6 | 9472 | RNAseq | -0.8032 | 0.0007 | |
| SRP219564 | AKAP6 | 9472 | RNAseq | -0.3124 | 0.6675 | |
| TCGA | AKAP6 | 9472 | RNAseq | -0.5117 | 0.0044 |
Upregulated datasets: 0; Downregulated datasets: 4.
Survival by AKAP6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of AKAP6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | AKAP6 | 9472 | 10 | 4 | 16 | |
| GSE20123 | AKAP6 | 9472 | 10 | 4 | 16 | |
| GSE43470 | AKAP6 | 9472 | 9 | 2 | 32 | |
| GSE46452 | AKAP6 | 9472 | 18 | 2 | 39 | |
| GSE47630 | AKAP6 | 9472 | 11 | 10 | 19 | |
| GSE54993 | AKAP6 | 9472 | 3 | 11 | 56 | |
| GSE54994 | AKAP6 | 9472 | 19 | 5 | 29 | |
| GSE60625 | AKAP6 | 9472 | 0 | 2 | 9 | |
| GSE74703 | AKAP6 | 9472 | 8 | 2 | 26 | |
| GSE74704 | AKAP6 | 9472 | 4 | 3 | 13 | |
| TCGA | AKAP6 | 9472 | 32 | 18 | 46 |
Total number of gains: 124; Total number of losses: 63; Total Number of normals: 301.
Somatic mutations of AKAP6:
Generating mutation plots.
Highly correlated genes for AKAP6:
Showing top 20/970 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| AKAP6 | UBXN10 | 0.822569 | 3 | 0 | 3 |
| AKAP6 | FLNA | 0.817423 | 3 | 0 | 3 |
| AKAP6 | CSDE1 | 0.787419 | 3 | 0 | 3 |
| AKAP6 | NFATC4 | 0.777431 | 3 | 0 | 3 |
| AKAP6 | LRCH2 | 0.774158 | 3 | 0 | 3 |
| AKAP6 | ZMAT4 | 0.772466 | 5 | 0 | 5 |
| AKAP6 | CYS1 | 0.770679 | 3 | 0 | 3 |
| AKAP6 | ASB5 | 0.76769 | 4 | 0 | 4 |
| AKAP6 | SCGB1D1 | 0.759179 | 3 | 0 | 3 |
| AKAP6 | MSRB2 | 0.7475 | 3 | 0 | 3 |
| AKAP6 | RBPMS2 | 0.747192 | 4 | 0 | 4 |
| AKAP6 | ARHGEF33 | 0.746177 | 3 | 0 | 3 |
| AKAP6 | CIITA | 0.745654 | 5 | 0 | 5 |
| AKAP6 | XKR4 | 0.738473 | 4 | 0 | 4 |
| AKAP6 | ATG10 | 0.737421 | 5 | 0 | 5 |
| AKAP6 | CER1 | 0.735535 | 4 | 0 | 4 |
| AKAP6 | FAM83D | 0.733439 | 3 | 0 | 3 |
| AKAP6 | TREML2 | 0.732074 | 4 | 0 | 4 |
| AKAP6 | JMY | 0.731186 | 3 | 0 | 3 |
| AKAP6 | RNF150 | 0.729911 | 4 | 0 | 4 |
For details and further investigation, click here
