| Full name: serpin family A member 5 | Alias Symbol: PAI3|PROCI | ||
| Type: protein-coding gene | Cytoband: 14q32.13 | ||
| Entrez ID: 5104 | HGNC ID: HGNC:8723 | Ensembl Gene: ENSG00000188488 | OMIM ID: 601841 |
| Drug and gene relationship at DGIdb | |||
SERPINA5 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04610 | Complement and coagulation cascades |
Expression of SERPINA5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SERPINA5 | 5104 | 209443_at | -0.0551 | 0.8573 | |
| GSE20347 | SERPINA5 | 5104 | 209443_at | 0.0557 | 0.5668 | |
| GSE23400 | SERPINA5 | 5104 | 209443_at | -0.2641 | 0.0000 | |
| GSE26886 | SERPINA5 | 5104 | 209443_at | 0.1161 | 0.4981 | |
| GSE29001 | SERPINA5 | 5104 | 209443_at | -0.0896 | 0.6009 | |
| GSE38129 | SERPINA5 | 5104 | 209443_at | -0.3607 | 0.0224 | |
| GSE45670 | SERPINA5 | 5104 | 209443_at | -0.0890 | 0.3642 | |
| GSE53622 | SERPINA5 | 5104 | 88651 | -0.5926 | 0.0034 | |
| GSE53624 | SERPINA5 | 5104 | 88651 | -0.8345 | 0.0004 | |
| GSE63941 | SERPINA5 | 5104 | 209443_at | 0.1315 | 0.5422 | |
| GSE77861 | SERPINA5 | 5104 | 209443_at | -0.1607 | 0.0711 | |
| GSE97050 | SERPINA5 | 5104 | A_24_P321766 | -0.2101 | 0.5259 | |
| SRP159526 | SERPINA5 | 5104 | RNAseq | -0.1310 | 0.8629 | |
| TCGA | SERPINA5 | 5104 | RNAseq | -3.0663 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by SERPINA5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SERPINA5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SERPINA5 | 5104 | 10 | 4 | 16 | |
| GSE20123 | SERPINA5 | 5104 | 10 | 3 | 17 | |
| GSE43470 | SERPINA5 | 5104 | 7 | 3 | 33 | |
| GSE46452 | SERPINA5 | 5104 | 16 | 3 | 40 | |
| GSE47630 | SERPINA5 | 5104 | 11 | 8 | 21 | |
| GSE54993 | SERPINA5 | 5104 | 3 | 8 | 59 | |
| GSE54994 | SERPINA5 | 5104 | 21 | 4 | 28 | |
| GSE60625 | SERPINA5 | 5104 | 0 | 2 | 9 | |
| GSE74703 | SERPINA5 | 5104 | 6 | 3 | 27 | |
| GSE74704 | SERPINA5 | 5104 | 6 | 3 | 11 | |
| TCGA | SERPINA5 | 5104 | 30 | 20 | 46 |
Total number of gains: 120; Total number of losses: 61; Total Number of normals: 307.
Somatic mutations of SERPINA5:
Generating mutation plots.
Highly correlated genes for SERPINA5:
Showing top 20/912 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SERPINA5 | HAND1 | 0.744798 | 3 | 0 | 3 |
| SERPINA5 | DNAH11 | 0.73688 | 3 | 0 | 3 |
| SERPINA5 | OPHN1 | 0.732952 | 4 | 0 | 4 |
| SERPINA5 | DACT2 | 0.727056 | 3 | 0 | 3 |
| SERPINA5 | SOX5 | 0.71392 | 4 | 0 | 3 |
| SERPINA5 | ENTPD2 | 0.711141 | 5 | 0 | 5 |
| SERPINA5 | SMO | 0.708868 | 4 | 0 | 3 |
| SERPINA5 | SIRT3 | 0.707598 | 5 | 0 | 5 |
| SERPINA5 | ZNF540 | 0.704121 | 3 | 0 | 3 |
| SERPINA5 | RASD2 | 0.697236 | 3 | 0 | 3 |
| SERPINA5 | ZMAT4 | 0.696769 | 6 | 0 | 6 |
| SERPINA5 | CGA | 0.696006 | 6 | 0 | 6 |
| SERPINA5 | CYGB | 0.694894 | 4 | 0 | 4 |
| SERPINA5 | OPRM1 | 0.693905 | 3 | 0 | 3 |
| SERPINA5 | AKAP6 | 0.691281 | 6 | 0 | 5 |
| SERPINA5 | CCDC7 | 0.689951 | 4 | 0 | 4 |
| SERPINA5 | PRKACG | 0.68319 | 5 | 0 | 5 |
| SERPINA5 | ARSK | 0.681967 | 3 | 0 | 3 |
| SERPINA5 | NPFF | 0.681799 | 5 | 0 | 5 |
| SERPINA5 | LONRF3 | 0.68125 | 3 | 0 | 3 |
For details and further investigation, click here
