| Full name: leucine rich repeat LGI family member 4 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 19q13.12 | ||
| Entrez ID: 163175 | HGNC ID: HGNC:18712 | Ensembl Gene: ENSG00000153902 | OMIM ID: 608303 |
| Drug and gene relationship at DGIdb | |||
Expression of LGI4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LGI4 | 163175 | 227821_at | -0.4364 | 0.3841 | |
| GSE26886 | LGI4 | 163175 | 227821_at | 0.0355 | 0.7864 | |
| GSE45670 | LGI4 | 163175 | 227821_at | -0.3240 | 0.0000 | |
| GSE53622 | LGI4 | 163175 | 32878 | -1.1337 | 0.0000 | |
| GSE53624 | LGI4 | 163175 | 32878 | -1.2009 | 0.0000 | |
| GSE63941 | LGI4 | 163175 | 227821_at | 0.3042 | 0.0651 | |
| GSE77861 | LGI4 | 163175 | 227821_at | -0.0080 | 0.9643 | |
| GSE97050 | LGI4 | 163175 | A_24_P310256 | -0.4762 | 0.2286 | |
| SRP064894 | LGI4 | 163175 | RNAseq | -0.5547 | 0.1755 | |
| SRP133303 | LGI4 | 163175 | RNAseq | -1.7874 | 0.0002 | |
| SRP159526 | LGI4 | 163175 | RNAseq | -1.5345 | 0.0001 | |
| SRP219564 | LGI4 | 163175 | RNAseq | -0.6564 | 0.4886 | |
| TCGA | LGI4 | 163175 | RNAseq | -1.0464 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 5.
Survival by LGI4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LGI4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LGI4 | 163175 | 6 | 4 | 20 | |
| GSE20123 | LGI4 | 163175 | 6 | 3 | 21 | |
| GSE43470 | LGI4 | 163175 | 4 | 7 | 32 | |
| GSE46452 | LGI4 | 163175 | 48 | 1 | 10 | |
| GSE47630 | LGI4 | 163175 | 9 | 5 | 26 | |
| GSE54993 | LGI4 | 163175 | 17 | 3 | 50 | |
| GSE54994 | LGI4 | 163175 | 8 | 9 | 36 | |
| GSE60625 | LGI4 | 163175 | 9 | 0 | 2 | |
| GSE74703 | LGI4 | 163175 | 4 | 4 | 28 | |
| GSE74704 | LGI4 | 163175 | 6 | 1 | 13 | |
| TCGA | LGI4 | 163175 | 21 | 11 | 64 |
Total number of gains: 138; Total number of losses: 48; Total Number of normals: 302.
Somatic mutations of LGI4:
Generating mutation plots.
Highly correlated genes for LGI4:
Showing top 20/342 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LGI4 | ACTBL2 | 0.747842 | 3 | 0 | 3 |
| LGI4 | CDH19 | 0.735814 | 5 | 0 | 5 |
| LGI4 | XKR4 | 0.716063 | 5 | 0 | 5 |
| LGI4 | SPTBN4 | 0.711471 | 3 | 0 | 3 |
| LGI4 | ITGA7 | 0.709271 | 5 | 0 | 5 |
| LGI4 | OMD | 0.704563 | 3 | 0 | 3 |
| LGI4 | SIRT3 | 0.700649 | 3 | 0 | 3 |
| LGI4 | LRRTM1 | 0.696079 | 6 | 0 | 5 |
| LGI4 | L1CAM | 0.692107 | 5 | 0 | 5 |
| LGI4 | ZMAT4 | 0.689307 | 3 | 0 | 3 |
| LGI4 | FXYD1 | 0.683508 | 5 | 0 | 5 |
| LGI4 | PRR26 | 0.682002 | 5 | 0 | 5 |
| LGI4 | DOCK3 | 0.680528 | 3 | 0 | 3 |
| LGI4 | LPP | 0.679521 | 5 | 0 | 5 |
| LGI4 | SLC35F1 | 0.679031 | 4 | 0 | 3 |
| LGI4 | CYP21A2 | 0.676878 | 3 | 0 | 3 |
| LGI4 | PPP1R14A | 0.675363 | 6 | 0 | 4 |
| LGI4 | CACNB2 | 0.674658 | 5 | 0 | 5 |
| LGI4 | SH3BGR | 0.673432 | 5 | 0 | 5 |
| LGI4 | C9orf47 | 0.67123 | 3 | 0 | 3 |
For details and further investigation, click here
