| Full name: thromboxane A2 receptor | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 19p13.3 | ||
| Entrez ID: 6915 | HGNC ID: HGNC:11608 | Ensembl Gene: ENSG00000006638 | OMIM ID: 188070 |
| Drug and gene relationship at DGIdb | |||
TBXA2R involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04020 | Calcium signaling pathway | |
| hsa04611 | Platelet activation |
Expression of TBXA2R:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TBXA2R | 6915 | 211590_x_at | -0.0766 | 0.7368 | |
| GSE20347 | TBXA2R | 6915 | 207555_s_at | -0.2044 | 0.0056 | |
| GSE23400 | TBXA2R | 6915 | 211590_x_at | -0.1393 | 0.0029 | |
| GSE26886 | TBXA2R | 6915 | 207555_s_at | -0.3125 | 0.0495 | |
| GSE29001 | TBXA2R | 6915 | 211590_x_at | -0.1418 | 0.4445 | |
| GSE38129 | TBXA2R | 6915 | 207555_s_at | -0.2533 | 0.0003 | |
| GSE45670 | TBXA2R | 6915 | 207555_s_at | -0.0704 | 0.4607 | |
| GSE53622 | TBXA2R | 6915 | 157713 | -0.9697 | 0.0000 | |
| GSE53624 | TBXA2R | 6915 | 157713 | -0.6481 | 0.0000 | |
| GSE63941 | TBXA2R | 6915 | 207555_s_at | 0.1021 | 0.6486 | |
| GSE77861 | TBXA2R | 6915 | 207555_s_at | -0.2780 | 0.0708 | |
| GSE97050 | TBXA2R | 6915 | A_33_P3307886 | 0.3835 | 0.1692 | |
| SRP064894 | TBXA2R | 6915 | RNAseq | -0.5492 | 0.0296 | |
| SRP133303 | TBXA2R | 6915 | RNAseq | -0.8137 | 0.0005 | |
| SRP159526 | TBXA2R | 6915 | RNAseq | -1.0707 | 0.0143 | |
| SRP193095 | TBXA2R | 6915 | RNAseq | -0.0623 | 0.7092 | |
| SRP219564 | TBXA2R | 6915 | RNAseq | -1.2596 | 0.0806 | |
| TCGA | TBXA2R | 6915 | RNAseq | -0.5393 | 0.0005 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by TBXA2R expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TBXA2R:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TBXA2R | 6915 | 5 | 3 | 22 | |
| GSE20123 | TBXA2R | 6915 | 4 | 2 | 24 | |
| GSE43470 | TBXA2R | 6915 | 1 | 9 | 33 | |
| GSE46452 | TBXA2R | 6915 | 47 | 1 | 11 | |
| GSE47630 | TBXA2R | 6915 | 5 | 7 | 28 | |
| GSE54993 | TBXA2R | 6915 | 16 | 3 | 51 | |
| GSE54994 | TBXA2R | 6915 | 8 | 16 | 29 | |
| GSE60625 | TBXA2R | 6915 | 9 | 0 | 2 | |
| GSE74703 | TBXA2R | 6915 | 1 | 6 | 29 | |
| GSE74704 | TBXA2R | 6915 | 1 | 2 | 17 | |
| TCGA | TBXA2R | 6915 | 10 | 19 | 67 |
Total number of gains: 107; Total number of losses: 68; Total Number of normals: 313.
Somatic mutations of TBXA2R:
Generating mutation plots.
Highly correlated genes for TBXA2R:
Showing top 20/854 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TBXA2R | FGF4 | 0.73745 | 4 | 0 | 4 |
| TBXA2R | NACAD | 0.706344 | 4 | 0 | 4 |
| TBXA2R | IL17B | 0.699968 | 5 | 0 | 5 |
| TBXA2R | DNMT3L | 0.697897 | 4 | 0 | 4 |
| TBXA2R | COLEC10 | 0.695087 | 3 | 0 | 3 |
| TBXA2R | ABCC6 | 0.693972 | 3 | 0 | 3 |
| TBXA2R | SIRT3 | 0.690287 | 5 | 0 | 4 |
| TBXA2R | GIP | 0.683803 | 4 | 0 | 4 |
| TBXA2R | HMCN2 | 0.678061 | 4 | 0 | 3 |
| TBXA2R | BVES-AS1 | 0.678007 | 4 | 0 | 3 |
| TBXA2R | GTPBP10 | 0.67798 | 3 | 0 | 3 |
| TBXA2R | RAX | 0.676022 | 6 | 0 | 6 |
| TBXA2R | KANK2 | 0.672812 | 5 | 0 | 4 |
| TBXA2R | CIITA | 0.672355 | 4 | 0 | 3 |
| TBXA2R | ZPBP | 0.670113 | 3 | 0 | 3 |
| TBXA2R | ASIP | 0.668226 | 3 | 0 | 3 |
| TBXA2R | FOXH1 | 0.666536 | 3 | 0 | 3 |
| TBXA2R | MYO1A | 0.666144 | 7 | 0 | 6 |
| TBXA2R | PRR34 | 0.665585 | 5 | 0 | 4 |
| TBXA2R | VGF | 0.665461 | 4 | 0 | 3 |
For details and further investigation, click here
