| Full name: solute carrier family 6 member 11 | Alias Symbol: GAT3 | ||
| Type: protein-coding gene | Cytoband: 3p25.3 | ||
| Entrez ID: 6538 | HGNC ID: HGNC:11044 | Ensembl Gene: ENSG00000132164 | OMIM ID: 607952 |
| Drug and gene relationship at DGIdb | |||
Expression of SLC6A11:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SLC6A11 | 6538 | 230286_at | -0.2586 | 0.6876 | |
| GSE20347 | SLC6A11 | 6538 | 207048_at | -0.1524 | 0.0526 | |
| GSE23400 | SLC6A11 | 6538 | 207048_at | -0.1903 | 0.0004 | |
| GSE26886 | SLC6A11 | 6538 | 230286_at | -0.2012 | 0.4321 | |
| GSE29001 | SLC6A11 | 6538 | 207048_at | -0.1036 | 0.5722 | |
| GSE38129 | SLC6A11 | 6538 | 207048_at | -0.1321 | 0.1440 | |
| GSE45670 | SLC6A11 | 6538 | 230286_at | -0.2205 | 0.2307 | |
| GSE53622 | SLC6A11 | 6538 | 60925 | -0.9800 | 0.0001 | |
| GSE53624 | SLC6A11 | 6538 | 60925 | -1.3239 | 0.0000 | |
| GSE63941 | SLC6A11 | 6538 | 207048_at | 0.0819 | 0.7223 | |
| GSE77861 | SLC6A11 | 6538 | 207048_at | -0.1358 | 0.5199 | |
| GSE97050 | SLC6A11 | 6538 | A_23_P418562 | -0.2535 | 0.6966 | |
| SRP007169 | SLC6A11 | 6538 | RNAseq | -2.9600 | 0.0005 | |
| SRP008496 | SLC6A11 | 6538 | RNAseq | -2.0499 | 0.0004 | |
| SRP064894 | SLC6A11 | 6538 | RNAseq | -0.7865 | 0.1614 | |
| SRP133303 | SLC6A11 | 6538 | RNAseq | -0.6738 | 0.1113 | |
| SRP159526 | SLC6A11 | 6538 | RNAseq | -2.9880 | 0.0000 | |
| SRP193095 | SLC6A11 | 6538 | RNAseq | -0.9035 | 0.0220 | |
| TCGA | SLC6A11 | 6538 | RNAseq | 1.2501 | 0.0203 |
Upregulated datasets: 1; Downregulated datasets: 4.
Survival by SLC6A11 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SLC6A11:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SLC6A11 | 6538 | 1 | 18 | 11 | |
| GSE20123 | SLC6A11 | 6538 | 2 | 18 | 10 | |
| GSE43470 | SLC6A11 | 6538 | 0 | 21 | 22 | |
| GSE46452 | SLC6A11 | 6538 | 2 | 17 | 40 | |
| GSE47630 | SLC6A11 | 6538 | 2 | 23 | 15 | |
| GSE54993 | SLC6A11 | 6538 | 6 | 1 | 63 | |
| GSE54994 | SLC6A11 | 6538 | 3 | 31 | 19 | |
| GSE60625 | SLC6A11 | 6538 | 5 | 0 | 6 | |
| GSE74703 | SLC6A11 | 6538 | 0 | 17 | 19 | |
| GSE74704 | SLC6A11 | 6538 | 1 | 10 | 9 | |
| TCGA | SLC6A11 | 6538 | 3 | 67 | 26 |
Total number of gains: 25; Total number of losses: 223; Total Number of normals: 240.
Somatic mutations of SLC6A11:
Generating mutation plots.
Highly correlated genes for SLC6A11:
Showing top 20/677 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SLC6A11 | RNF222 | 0.720921 | 3 | 0 | 3 |
| SLC6A11 | IGH | 0.719801 | 5 | 0 | 4 |
| SLC6A11 | KPRP | 0.701585 | 3 | 0 | 3 |
| SLC6A11 | NCCRP1 | 0.691696 | 3 | 0 | 3 |
| SLC6A11 | C19orf33 | 0.689534 | 4 | 0 | 4 |
| SLC6A11 | DEFA4 | 0.684575 | 4 | 0 | 4 |
| SLC6A11 | AMACR | 0.682057 | 4 | 0 | 4 |
| SLC6A11 | OR10C1 | 0.680304 | 4 | 0 | 4 |
| SLC6A11 | NR2E3 | 0.675019 | 3 | 0 | 3 |
| SLC6A11 | SSTR5 | 0.670075 | 4 | 0 | 4 |
| SLC6A11 | LZTS1 | 0.669783 | 3 | 0 | 3 |
| SLC6A11 | CLDN9 | 0.668854 | 7 | 0 | 7 |
| SLC6A11 | FAM153A | 0.668031 | 5 | 0 | 5 |
| SLC6A11 | FUT5 | 0.666412 | 5 | 0 | 4 |
| SLC6A11 | HES5 | 0.665749 | 3 | 0 | 3 |
| SLC6A11 | ARR3 | 0.663076 | 4 | 0 | 3 |
| SLC6A11 | APOA1 | 0.663003 | 6 | 0 | 6 |
| SLC6A11 | TMEM37 | 0.662328 | 3 | 0 | 3 |
| SLC6A11 | MYOG | 0.658248 | 3 | 0 | 3 |
| SLC6A11 | FAM163B | 0.658192 | 3 | 0 | 3 |
For details and further investigation, click here
