| Full name: apolipoprotein A1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 11q23.3 | ||
| Entrez ID: 335 | HGNC ID: HGNC:600 | Ensembl Gene: ENSG00000118137 | OMIM ID: 107680 |
| Drug and gene relationship at DGIdb | |||
APOA1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa03320 | PPAR signaling pathway |
Expression of APOA1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | APOA1 | 335 | 204450_x_at | -0.0867 | 0.6966 | |
| GSE20347 | APOA1 | 335 | 204450_x_at | -0.0949 | 0.1810 | |
| GSE23400 | APOA1 | 335 | 217073_x_at | -0.3510 | 0.0000 | |
| GSE26886 | APOA1 | 335 | 217073_x_at | 0.0195 | 0.9016 | |
| GSE29001 | APOA1 | 335 | 217073_x_at | -0.1586 | 0.2299 | |
| GSE38129 | APOA1 | 335 | 204450_x_at | -0.2730 | 0.0134 | |
| GSE45670 | APOA1 | 335 | 204450_x_at | -0.0621 | 0.5458 | |
| GSE53622 | APOA1 | 335 | 151583 | -2.1864 | 0.0000 | |
| GSE53624 | APOA1 | 335 | 151583 | -2.5393 | 0.0000 | |
| GSE63941 | APOA1 | 335 | 217073_x_at | 0.0080 | 0.9665 | |
| GSE77861 | APOA1 | 335 | 217073_x_at | -0.2089 | 0.0677 | |
| GSE97050 | APOA1 | 335 | A_33_P3298539 | -0.8487 | 0.1861 | |
| TCGA | APOA1 | 335 | RNAseq | -3.1677 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by APOA1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of APOA1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | APOA1 | 335 | 0 | 13 | 17 | |
| GSE20123 | APOA1 | 335 | 0 | 13 | 17 | |
| GSE43470 | APOA1 | 335 | 2 | 8 | 33 | |
| GSE46452 | APOA1 | 335 | 3 | 26 | 30 | |
| GSE47630 | APOA1 | 335 | 2 | 19 | 19 | |
| GSE54993 | APOA1 | 335 | 10 | 0 | 60 | |
| GSE54994 | APOA1 | 335 | 5 | 19 | 29 | |
| GSE60625 | APOA1 | 335 | 0 | 3 | 8 | |
| GSE74703 | APOA1 | 335 | 1 | 5 | 30 | |
| GSE74704 | APOA1 | 335 | 0 | 9 | 11 | |
| TCGA | APOA1 | 335 | 5 | 50 | 41 |
Total number of gains: 28; Total number of losses: 165; Total Number of normals: 295.
Somatic mutations of APOA1:
Generating mutation plots.
Highly correlated genes for APOA1:
Showing top 20/1234 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| APOA1 | ARID5A | 0.922618 | 3 | 0 | 3 |
| APOA1 | FAM163B | 0.918917 | 3 | 0 | 3 |
| APOA1 | NCCRP1 | 0.89048 | 3 | 0 | 3 |
| APOA1 | HCG22 | 0.860409 | 3 | 0 | 3 |
| APOA1 | KRTAP20-1 | 0.847244 | 3 | 0 | 3 |
| APOA1 | MUC22 | 0.846379 | 3 | 0 | 3 |
| APOA1 | PRSS27 | 0.84629 | 4 | 0 | 4 |
| APOA1 | TMPRSS11A | 0.844304 | 3 | 0 | 3 |
| APOA1 | KPRP | 0.84312 | 3 | 0 | 3 |
| APOA1 | OTOP3 | 0.835334 | 3 | 0 | 3 |
| APOA1 | RNF222 | 0.831947 | 3 | 0 | 3 |
| APOA1 | MFSD2B | 0.82385 | 3 | 0 | 3 |
| APOA1 | CYSRT1 | 0.816909 | 3 | 0 | 3 |
| APOA1 | HECTD1 | 0.81348 | 3 | 0 | 3 |
| APOA1 | TECPR1 | 0.80196 | 3 | 0 | 3 |
| APOA1 | AIF1L | 0.789543 | 4 | 0 | 4 |
| APOA1 | OR10G8 | 0.785929 | 3 | 0 | 3 |
| APOA1 | LYNX1 | 0.784841 | 4 | 0 | 4 |
| APOA1 | C6orf132 | 0.781725 | 4 | 0 | 4 |
| APOA1 | CYP3A7 | 0.777945 | 3 | 0 | 3 |
For details and further investigation, click here
