| Full name: leucine zipper tumor suppressor 1 | Alias Symbol: FEZ1 | ||
| Type: protein-coding gene | Cytoband: 8p21.3 | ||
| Entrez ID: 11178 | HGNC ID: HGNC:13861 | Ensembl Gene: ENSG00000061337 | OMIM ID: 606551 |
| Drug and gene relationship at DGIdb | |||
Expression of LZTS1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LZTS1 | 11178 | 47550_at | -0.2227 | 0.7782 | |
| GSE20347 | LZTS1 | 11178 | 222107_x_at | 0.0686 | 0.4838 | |
| GSE23400 | LZTS1 | 11178 | 222107_x_at | -0.0676 | 0.0900 | |
| GSE26886 | LZTS1 | 11178 | 47550_at | 0.3528 | 0.4106 | |
| GSE29001 | LZTS1 | 11178 | 222107_x_at | -0.1164 | 0.5580 | |
| GSE38129 | LZTS1 | 11178 | 222107_x_at | -0.0577 | 0.4585 | |
| GSE45670 | LZTS1 | 11178 | 222107_x_at | 0.1526 | 0.1365 | |
| GSE53622 | LZTS1 | 11178 | 103276 | -0.0394 | 0.8750 | |
| GSE53624 | LZTS1 | 11178 | 102915 | -0.3589 | 0.0049 | |
| GSE63941 | LZTS1 | 11178 | 222107_x_at | -0.0043 | 0.9821 | |
| GSE77861 | LZTS1 | 11178 | 222107_x_at | -0.0170 | 0.9102 | |
| GSE97050 | LZTS1 | 11178 | A_33_P3212305 | 0.3509 | 0.2151 | |
| SRP007169 | LZTS1 | 11178 | RNAseq | 0.7374 | 0.2539 | |
| SRP064894 | LZTS1 | 11178 | RNAseq | -0.6013 | 0.0319 | |
| SRP133303 | LZTS1 | 11178 | RNAseq | -0.5694 | 0.0414 | |
| SRP159526 | LZTS1 | 11178 | RNAseq | -0.6296 | 0.1503 | |
| SRP193095 | LZTS1 | 11178 | RNAseq | -0.9224 | 0.0003 | |
| SRP219564 | LZTS1 | 11178 | RNAseq | -0.3134 | 0.3692 | |
| TCGA | LZTS1 | 11178 | RNAseq | 0.3995 | 0.0057 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by LZTS1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LZTS1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LZTS1 | 11178 | 4 | 10 | 16 | |
| GSE20123 | LZTS1 | 11178 | 4 | 10 | 16 | |
| GSE43470 | LZTS1 | 11178 | 4 | 8 | 31 | |
| GSE46452 | LZTS1 | 11178 | 14 | 13 | 32 | |
| GSE47630 | LZTS1 | 11178 | 10 | 8 | 22 | |
| GSE54993 | LZTS1 | 11178 | 2 | 14 | 54 | |
| GSE54994 | LZTS1 | 11178 | 8 | 18 | 27 | |
| GSE60625 | LZTS1 | 11178 | 3 | 0 | 8 | |
| GSE74703 | LZTS1 | 11178 | 4 | 7 | 25 | |
| GSE74704 | LZTS1 | 11178 | 3 | 6 | 11 | |
| TCGA | LZTS1 | 11178 | 14 | 42 | 40 |
Total number of gains: 70; Total number of losses: 136; Total Number of normals: 282.
Somatic mutations of LZTS1:
Generating mutation plots.
Highly correlated genes for LZTS1:
Showing top 20/850 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LZTS1 | LMAN1 | 0.855026 | 3 | 0 | 3 |
| LZTS1 | NAGLU | 0.772678 | 4 | 0 | 4 |
| LZTS1 | FBXL18 | 0.769474 | 3 | 0 | 3 |
| LZTS1 | BUB1 | 0.756572 | 3 | 0 | 3 |
| LZTS1 | CHRNB1 | 0.742674 | 3 | 0 | 3 |
| LZTS1 | ZBTB33 | 0.73835 | 3 | 0 | 3 |
| LZTS1 | GK | 0.734206 | 3 | 0 | 3 |
| LZTS1 | MAPK11 | 0.722988 | 4 | 0 | 3 |
| LZTS1 | MTAP | 0.721985 | 6 | 0 | 5 |
| LZTS1 | GNGT2 | 0.721813 | 3 | 0 | 3 |
| LZTS1 | IRF4 | 0.719724 | 4 | 0 | 4 |
| LZTS1 | RBFADN | 0.71798 | 3 | 0 | 3 |
| LZTS1 | ZNF771 | 0.717447 | 5 | 0 | 4 |
| LZTS1 | CIITA | 0.711823 | 5 | 0 | 5 |
| LZTS1 | CDH15 | 0.711577 | 6 | 0 | 6 |
| LZTS1 | CRX | 0.711332 | 4 | 0 | 3 |
| LZTS1 | UNC93B1 | 0.710077 | 3 | 0 | 3 |
| LZTS1 | DECR2 | 0.706503 | 3 | 0 | 3 |
| LZTS1 | FGB | 0.704801 | 3 | 0 | 3 |
| LZTS1 | OS9 | 0.703282 | 3 | 0 | 3 |
For details and further investigation, click here
