| Full name: defensin alpha 4 | Alias Symbol: HP-4 | ||
| Type: protein-coding gene | Cytoband: 8p23.1 | ||
| Entrez ID: 1669 | HGNC ID: HGNC:2763 | Ensembl Gene: ENSG00000164821 | OMIM ID: 601157 |
| Drug and gene relationship at DGIdb | |||
Expression of DEFA4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DEFA4 | 1669 | 207269_at | 0.0378 | 0.9088 | |
| GSE20347 | DEFA4 | 1669 | 207269_at | -0.0166 | 0.7959 | |
| GSE23400 | DEFA4 | 1669 | 207269_at | -0.0732 | 0.0800 | |
| GSE26886 | DEFA4 | 1669 | 207269_at | 0.0330 | 0.8240 | |
| GSE29001 | DEFA4 | 1669 | 207269_at | -0.2071 | 0.2603 | |
| GSE38129 | DEFA4 | 1669 | 207269_at | -0.0876 | 0.3245 | |
| GSE45670 | DEFA4 | 1669 | 207269_at | -0.0146 | 0.8833 | |
| GSE53622 | DEFA4 | 1669 | 22935 | 0.3648 | 0.1252 | |
| GSE53624 | DEFA4 | 1669 | 22935 | 0.1867 | 0.1331 | |
| GSE63941 | DEFA4 | 1669 | 207269_at | 0.2643 | 0.0545 | |
| GSE77861 | DEFA4 | 1669 | 207269_at | -0.0615 | 0.4955 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by DEFA4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DEFA4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DEFA4 | 1669 | 4 | 11 | 15 | |
| GSE20123 | DEFA4 | 1669 | 4 | 11 | 15 | |
| GSE43470 | DEFA4 | 1669 | 4 | 10 | 29 | |
| GSE46452 | DEFA4 | 1669 | 12 | 14 | 33 | |
| GSE47630 | DEFA4 | 1669 | 9 | 7 | 24 | |
| GSE54993 | DEFA4 | 1669 | 3 | 14 | 53 | |
| GSE54994 | DEFA4 | 1669 | 10 | 19 | 24 | |
| GSE60625 | DEFA4 | 1669 | 3 | 0 | 8 | |
| GSE74703 | DEFA4 | 1669 | 4 | 8 | 24 | |
| GSE74704 | DEFA4 | 1669 | 3 | 7 | 10 | |
| TCGA | DEFA4 | 1669 | 13 | 40 | 43 |
Total number of gains: 69; Total number of losses: 141; Total Number of normals: 278.
Somatic mutations of DEFA4:
Generating mutation plots.
Highly correlated genes for DEFA4:
Showing top 20/1017 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DEFA4 | NOS1 | 0.731178 | 5 | 0 | 5 |
| DEFA4 | PTH | 0.717015 | 3 | 0 | 3 |
| DEFA4 | SFRP5 | 0.700733 | 4 | 0 | 4 |
| DEFA4 | FSHR | 0.700475 | 3 | 0 | 3 |
| DEFA4 | GPR21 | 0.699345 | 3 | 0 | 3 |
| DEFA4 | AP4S1 | 0.698287 | 5 | 0 | 5 |
| DEFA4 | FSTL4 | 0.696218 | 4 | 0 | 4 |
| DEFA4 | BFSP2-AS1 | 0.694007 | 3 | 0 | 3 |
| DEFA4 | HABP2 | 0.691744 | 5 | 0 | 5 |
| DEFA4 | CYP2D6 | 0.68843 | 6 | 0 | 6 |
| DEFA4 | SYNGR4 | 0.685332 | 3 | 0 | 3 |
| DEFA4 | SLC6A11 | 0.684575 | 4 | 0 | 4 |
| DEFA4 | NMNAT2 | 0.683291 | 3 | 0 | 3 |
| DEFA4 | NPAP1 | 0.68268 | 4 | 0 | 4 |
| DEFA4 | HAND1 | 0.680522 | 4 | 0 | 4 |
| DEFA4 | CRHR2 | 0.679318 | 4 | 0 | 4 |
| DEFA4 | S1PR2 | 0.677049 | 4 | 0 | 4 |
| DEFA4 | KIR2DS5 | 0.676868 | 6 | 0 | 6 |
| DEFA4 | PSG9 | 0.675568 | 6 | 0 | 5 |
| DEFA4 | ERBB4 | 0.674728 | 3 | 0 | 3 |
For details and further investigation, click here
