| Full name: luteinizing hormone subunit beta | Alias Symbol: LSH-B|CGB4|hLHB | ||
| Type: protein-coding gene | Cytoband: 19q13.3 | ||
| Entrez ID: 3972 | HGNC ID: HGNC:6584 | Ensembl Gene: ENSG00000104826 | OMIM ID: 152780 |
| Drug and gene relationship at DGIdb | |||
LHB involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04913 | Ovarian steroidogenesis | |
| hsa04917 | Prolactin signaling pathway |
Expression of LHB:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE53622 | LHB | 3972 | 33250 | 0.3497 | 0.0001 | |
| GSE53624 | LHB | 3972 | 33250 | 0.5055 | 0.0000 | |
| GSE97050 | LHB | 3972 | A_23_P218505 | 0.4473 | 0.2451 | |
| TCGA | LHB | 3972 | RNAseq | 0.0612 | 0.9093 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by LHB expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LHB:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LHB | 3972 | 4 | 4 | 22 | |
| GSE20123 | LHB | 3972 | 4 | 3 | 23 | |
| GSE43470 | LHB | 3972 | 4 | 10 | 29 | |
| GSE46452 | LHB | 3972 | 45 | 1 | 13 | |
| GSE47630 | LHB | 3972 | 9 | 6 | 25 | |
| GSE54993 | LHB | 3972 | 17 | 4 | 49 | |
| GSE54994 | LHB | 3972 | 4 | 14 | 35 | |
| GSE60625 | LHB | 3972 | 9 | 0 | 2 | |
| GSE74703 | LHB | 3972 | 4 | 7 | 25 | |
| GSE74704 | LHB | 3972 | 4 | 1 | 15 | |
| TCGA | LHB | 3972 | 14 | 18 | 64 |
Total number of gains: 118; Total number of losses: 68; Total Number of normals: 302.
Somatic mutations of LHB:
Generating mutation plots.
Highly correlated genes for LHB:
Showing top 20/250 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LHB | SLC6A3 | 0.837536 | 3 | 0 | 3 |
| LHB | NKX6-3 | 0.822567 | 3 | 0 | 3 |
| LHB | CNOT3 | 0.808863 | 3 | 0 | 3 |
| LHB | FFAR1 | 0.808316 | 3 | 0 | 3 |
| LHB | CLDN9 | 0.807172 | 3 | 0 | 3 |
| LHB | AGRP | 0.802226 | 3 | 0 | 3 |
| LHB | DEFB121 | 0.802106 | 3 | 0 | 3 |
| LHB | MRGPRG | 0.79792 | 3 | 0 | 3 |
| LHB | MEGF11 | 0.793806 | 3 | 0 | 3 |
| LHB | NTNG2 | 0.792197 | 3 | 0 | 3 |
| LHB | SERPINA10 | 0.791693 | 3 | 0 | 3 |
| LHB | POM121L12 | 0.791131 | 3 | 0 | 3 |
| LHB | NPPB | 0.790284 | 3 | 0 | 3 |
| LHB | STRC | 0.788123 | 3 | 0 | 3 |
| LHB | PRDM13 | 0.787295 | 3 | 0 | 3 |
| LHB | AQP8 | 0.787279 | 3 | 0 | 3 |
| LHB | RBM43 | 0.785038 | 3 | 0 | 3 |
| LHB | SPRED3 | 0.783093 | 3 | 0 | 3 |
| LHB | GPR32 | 0.782882 | 3 | 0 | 3 |
| LHB | FBRSL1 | 0.782377 | 3 | 0 | 3 |
For details and further investigation, click here
