| Full name: complement component 4 binding protein alpha | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 1q32.2 | ||
| Entrez ID: 722 | HGNC ID: HGNC:1325 | Ensembl Gene: ENSG00000123838 | OMIM ID: 120830 |
| Drug and gene relationship at DGIdb | |||
C4BPA involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05133 | Pertussis |
Expression of C4BPA:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | C4BPA | 722 | 205654_at | 0.1070 | 0.7288 | |
| GSE20347 | C4BPA | 722 | 205654_at | 0.0930 | 0.3724 | |
| GSE23400 | C4BPA | 722 | 205654_at | -0.0720 | 0.0735 | |
| GSE26886 | C4BPA | 722 | 205654_at | 0.0411 | 0.7527 | |
| GSE29001 | C4BPA | 722 | 205654_at | 0.0425 | 0.7807 | |
| GSE38129 | C4BPA | 722 | 205654_at | 0.0040 | 0.9675 | |
| GSE45670 | C4BPA | 722 | 205654_at | 0.1854 | 0.0470 | |
| GSE53622 | C4BPA | 722 | 14503 | -0.0255 | 0.7902 | |
| GSE53624 | C4BPA | 722 | 14503 | -0.1967 | 0.0396 | |
| GSE63941 | C4BPA | 722 | 205654_at | 0.1352 | 0.4753 | |
| GSE77861 | C4BPA | 722 | 205654_at | -0.0997 | 0.2979 | |
| GSE97050 | C4BPA | 722 | A_23_P97541 | -0.0218 | 0.9381 | |
| TCGA | C4BPA | 722 | RNAseq | -0.8515 | 0.5273 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by C4BPA expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of C4BPA:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | C4BPA | 722 | 11 | 0 | 19 | |
| GSE20123 | C4BPA | 722 | 11 | 0 | 19 | |
| GSE43470 | C4BPA | 722 | 8 | 0 | 35 | |
| GSE46452 | C4BPA | 722 | 3 | 1 | 55 | |
| GSE47630 | C4BPA | 722 | 14 | 0 | 26 | |
| GSE54993 | C4BPA | 722 | 0 | 6 | 64 | |
| GSE54994 | C4BPA | 722 | 14 | 0 | 39 | |
| GSE60625 | C4BPA | 722 | 0 | 0 | 11 | |
| GSE74703 | C4BPA | 722 | 8 | 0 | 28 | |
| GSE74704 | C4BPA | 722 | 5 | 0 | 15 | |
| TCGA | C4BPA | 722 | 45 | 3 | 48 |
Total number of gains: 119; Total number of losses: 10; Total Number of normals: 359.
Somatic mutations of C4BPA:
Generating mutation plots.
Highly correlated genes for C4BPA:
Showing top 20/874 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| C4BPA | OBSL1 | 0.843737 | 3 | 0 | 3 |
| C4BPA | SLC6A3 | 0.818847 | 3 | 0 | 3 |
| C4BPA | GHSR | 0.761519 | 3 | 0 | 3 |
| C4BPA | MEPE | 0.761154 | 6 | 0 | 6 |
| C4BPA | PRKAR1B | 0.75783 | 3 | 0 | 3 |
| C4BPA | TSKS | 0.755324 | 3 | 0 | 3 |
| C4BPA | ERN1 | 0.752175 | 4 | 0 | 4 |
| C4BPA | LHX9 | 0.747513 | 3 | 0 | 3 |
| C4BPA | FAM71A | 0.743774 | 3 | 0 | 3 |
| C4BPA | F2 | 0.738703 | 3 | 0 | 3 |
| C4BPA | PHOSPHO1 | 0.733296 | 3 | 0 | 3 |
| C4BPA | PALM3 | 0.733283 | 4 | 0 | 3 |
| C4BPA | ZMYND10 | 0.730751 | 3 | 0 | 3 |
| C4BPA | TBC1D10C | 0.730534 | 3 | 0 | 3 |
| C4BPA | MAGEE1 | 0.729348 | 3 | 0 | 3 |
| C4BPA | MYLK3 | 0.724605 | 3 | 0 | 3 |
| C4BPA | LRTM1 | 0.722812 | 5 | 0 | 5 |
| C4BPA | SPTA1 | 0.72171 | 4 | 0 | 3 |
| C4BPA | SLC9A7 | 0.720299 | 4 | 0 | 4 |
| C4BPA | KIR3DL3 | 0.720187 | 7 | 0 | 6 |
For details and further investigation, click here
