| Full name: speedy/RINGO cell cycle regulator family member A | Alias Symbol: SPY1|Ringo3 | ||
| Type: protein-coding gene | Cytoband: 2p23.2 | ||
| Entrez ID: 245711 | HGNC ID: HGNC:30613 | Ensembl Gene: ENSG00000163806 | OMIM ID: 614029 |
| Drug and gene relationship at DGIdb | |||
SPDYA involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04114 | Oocyte meiosis | |
| hsa04914 | Progesterone-mediated oocyte maturation |
Expression of SPDYA:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SPDYA | 245711 | 238262_at | -0.0736 | 0.7329 | |
| GSE26886 | SPDYA | 245711 | 238262_at | -0.0138 | 0.9110 | |
| GSE45670 | SPDYA | 245711 | 238262_at | 0.3996 | 0.0344 | |
| GSE53622 | SPDYA | 245711 | 101405 | 0.7353 | 0.0000 | |
| GSE53624 | SPDYA | 245711 | 101405 | 0.3260 | 0.0038 | |
| GSE63941 | SPDYA | 245711 | 238262_at | 0.0938 | 0.6345 | |
| GSE77861 | SPDYA | 245711 | 238262_at | -0.0673 | 0.3555 | |
| GSE97050 | SPDYA | 245711 | A_32_P102935 | 0.1059 | 0.6249 | |
| SRP133303 | SPDYA | 245711 | RNAseq | 1.0851 | 0.0001 | |
| SRP159526 | SPDYA | 245711 | RNAseq | 1.0223 | 0.1289 | |
| SRP219564 | SPDYA | 245711 | RNAseq | 0.6060 | 0.4183 | |
| TCGA | SPDYA | 245711 | RNAseq | 0.2234 | 0.2033 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by SPDYA expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SPDYA:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SPDYA | 245711 | 11 | 2 | 17 | |
| GSE20123 | SPDYA | 245711 | 11 | 2 | 17 | |
| GSE43470 | SPDYA | 245711 | 3 | 1 | 39 | |
| GSE46452 | SPDYA | 245711 | 2 | 4 | 53 | |
| GSE47630 | SPDYA | 245711 | 8 | 0 | 32 | |
| GSE54993 | SPDYA | 245711 | 0 | 6 | 64 | |
| GSE54994 | SPDYA | 245711 | 10 | 0 | 43 | |
| GSE60625 | SPDYA | 245711 | 0 | 3 | 8 | |
| GSE74703 | SPDYA | 245711 | 3 | 0 | 33 | |
| GSE74704 | SPDYA | 245711 | 9 | 1 | 10 | |
| TCGA | SPDYA | 245711 | 36 | 2 | 58 |
Total number of gains: 93; Total number of losses: 21; Total Number of normals: 374.
Somatic mutations of SPDYA:
Generating mutation plots.
Highly correlated genes for SPDYA:
Showing all 14 correlated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SPDYA | WDR44 | 0.70165 | 3 | 0 | 3 |
| SPDYA | ATP6AP1L | 0.657457 | 3 | 0 | 3 |
| SPDYA | EFNA2 | 0.645416 | 3 | 0 | 3 |
| SPDYA | VHL | 0.638327 | 4 | 0 | 3 |
| SPDYA | ATP10D | 0.636326 | 3 | 0 | 3 |
| SPDYA | ZNF705G | 0.624067 | 4 | 0 | 3 |
| SPDYA | DKK4 | 0.617501 | 3 | 0 | 3 |
| SPDYA | SUCLA2 | 0.58722 | 3 | 0 | 3 |
| SPDYA | RAP1GAP | 0.586554 | 4 | 0 | 3 |
| SPDYA | ALOX12B | 0.578268 | 4 | 0 | 3 |
| SPDYA | ZNF280A | 0.569875 | 3 | 0 | 3 |
| SPDYA | PPP1R14D | 0.563729 | 4 | 0 | 3 |
| SPDYA | DND1 | 0.546298 | 4 | 0 | 3 |
| SPDYA | LRRC71 | 0.523552 | 4 | 0 | 3 |
For details and further investigation, click here
