| Full name: dickkopf WNT signaling pathway inhibitor 4 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 8p11.21 | ||
| Entrez ID: 27121 | HGNC ID: HGNC:2894 | Ensembl Gene: ENSG00000104371 | OMIM ID: 605417 |
| Drug and gene relationship at DGIdb | |||
DKK4 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04310 | Wnt signaling pathway |
Expression of DKK4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DKK4 | 27121 | 206619_at | -0.9705 | 0.0616 | |
| GSE20347 | DKK4 | 27121 | 206619_at | -0.4480 | 0.0000 | |
| GSE23400 | DKK4 | 27121 | 206619_at | -0.4799 | 0.0000 | |
| GSE26886 | DKK4 | 27121 | 206619_at | -0.8189 | 0.0001 | |
| GSE29001 | DKK4 | 27121 | 206619_at | -1.0626 | 0.0001 | |
| GSE38129 | DKK4 | 27121 | 206619_at | -0.6131 | 0.0000 | |
| GSE45670 | DKK4 | 27121 | 206619_at | -0.4992 | 0.1481 | |
| GSE53622 | DKK4 | 27121 | 28762 | -2.1521 | 0.0000 | |
| GSE53624 | DKK4 | 27121 | 28762 | -3.0094 | 0.0000 | |
| GSE63941 | DKK4 | 27121 | 206619_at | 0.0698 | 0.6165 | |
| GSE77861 | DKK4 | 27121 | 206619_at | -0.6904 | 0.0357 | |
| GSE97050 | DKK4 | 27121 | A_23_P94275 | -0.3476 | 0.3062 | |
| SRP007169 | DKK4 | 27121 | RNAseq | -5.4735 | 0.0000 | |
| SRP064894 | DKK4 | 27121 | RNAseq | -4.4556 | 0.0000 | |
| SRP133303 | DKK4 | 27121 | RNAseq | -3.5171 | 0.0000 | |
| SRP159526 | DKK4 | 27121 | RNAseq | -4.4706 | 0.0000 | |
| SRP219564 | DKK4 | 27121 | RNAseq | -1.8934 | 0.0682 | |
| TCGA | DKK4 | 27121 | RNAseq | -0.7645 | 0.4110 |
Upregulated datasets: 0; Downregulated datasets: 7.
Survival by DKK4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DKK4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DKK4 | 27121 | 10 | 5 | 15 | |
| GSE20123 | DKK4 | 27121 | 10 | 5 | 15 | |
| GSE43470 | DKK4 | 27121 | 9 | 6 | 28 | |
| GSE46452 | DKK4 | 27121 | 19 | 5 | 35 | |
| GSE47630 | DKK4 | 27121 | 22 | 1 | 17 | |
| GSE54993 | DKK4 | 27121 | 1 | 16 | 53 | |
| GSE54994 | DKK4 | 27121 | 19 | 7 | 27 | |
| GSE60625 | DKK4 | 27121 | 3 | 0 | 8 | |
| GSE74703 | DKK4 | 27121 | 8 | 5 | 23 | |
| GSE74704 | DKK4 | 27121 | 9 | 2 | 9 | |
| TCGA | DKK4 | 27121 | 41 | 21 | 34 |
Total number of gains: 151; Total number of losses: 73; Total Number of normals: 264.
Somatic mutations of DKK4:
Generating mutation plots.
Highly correlated genes for DKK4:
Showing top 20/980 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DKK4 | FAM163B | 0.842041 | 3 | 0 | 3 |
| DKK4 | CLDN17 | 0.79253 | 10 | 0 | 10 |
| DKK4 | GYS2 | 0.779932 | 10 | 0 | 10 |
| DKK4 | OR2Z1 | 0.773654 | 3 | 0 | 3 |
| DKK4 | IL36A | 0.773543 | 11 | 0 | 11 |
| DKK4 | NCCRP1 | 0.773406 | 3 | 0 | 3 |
| DKK4 | MFSD2B | 0.773353 | 3 | 0 | 3 |
| DKK4 | MUC22 | 0.771439 | 3 | 0 | 3 |
| DKK4 | TRIP10 | 0.769641 | 10 | 0 | 10 |
| DKK4 | KLKB1 | 0.767872 | 6 | 0 | 6 |
| DKK4 | KRTAP20-1 | 0.766037 | 3 | 0 | 3 |
| DKK4 | PRSS2 | 0.760892 | 9 | 0 | 9 |
| DKK4 | ENDOU | 0.759683 | 10 | 0 | 10 |
| DKK4 | TEN1 | 0.759052 | 3 | 0 | 3 |
| DKK4 | PRSS27 | 0.758959 | 7 | 0 | 7 |
| DKK4 | MAPK3 | 0.75814 | 10 | 0 | 10 |
| DKK4 | KPRP | 0.756831 | 3 | 0 | 3 |
| DKK4 | CAPN5 | 0.755924 | 10 | 0 | 10 |
| DKK4 | FAM214A | 0.755811 | 6 | 0 | 6 |
| DKK4 | ST3GAL4 | 0.753817 | 11 | 0 | 11 |
For details and further investigation, click here
