VHL

 

Full name: von Hippel-Lindau tumor suppressor Alias Symbol: VHL1
Type: protein-coding gene Cytoband: 3p25.3
Entrez ID: 7428 HGNC ID: HGNC:12687 Ensembl Gene: ENSG00000134086 OMIM ID: 608537
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 159/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

VHL involved pathways:

KEGG pathway Description View
hsa04066HIF-1 signaling pathway
hsa05200Pathways in cancer

 

Expression of VHL:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 VHL 7428 1559227_s_at 0.2785 0.4053
GSE20347 VHL 7428 203844_at -0.0210 0.7523
GSE23400 VHL 7428 203844_at -0.0362 0.0188
GSE26886 VHL 7428 1559227_s_at -0.0473 0.8365
GSE29001 VHL 7428 203844_at 0.0823 0.4365
GSE38129 VHL 7428 203844_at -0.0308 0.5109
GSE45670 VHL 7428 1559227_s_at 0.1292 0.2968
GSE53622 VHL 7428 29804 0.2936 0.0020
GSE53624 VHL 7428 29804 0.1127 0.1093
GSE63941 VHL 7428 1559227_s_at 0.3335 0.4758
GSE77861 VHL 7428 1559227_s_at -0.2132 0.3865
GSE97050 VHL 7428 A_33_P3419938 -0.0030 0.9898
SRP007169 VHL 7428 RNAseq 1.5894 0.0469
SRP008496 VHL 7428 RNAseq 0.0016 0.9952
SRP064894 VHL 7428 RNAseq -0.0453 0.7172
SRP133303 VHL 7428 RNAseq 0.0519 0.6485
SRP159526 VHL 7428 RNAseq 0.0871 0.4891
SRP193095 VHL 7428 RNAseq -0.1186 0.1433
SRP219564 VHL 7428 RNAseq -0.0550 0.8538
TCGA VHL 7428 RNAseq 0.0261 0.6688

Upregulated datasets: 1; Downregulated datasets: 0.  

 

Survival by VHL expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of VHL:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 VHL 7428 1 18 11
GSE20123 VHL 7428 1 18 11
GSE43470 VHL 7428 1 20 22
GSE46452 VHL 7428 2 17 40
GSE47630 VHL 7428 2 23 15
GSE54993 VHL 7428 6 1 63
GSE54994 VHL 7428 3 31 19
GSE60625 VHL 7428 5 0 6
GSE74703 VHL 7428 1 16 19
GSE74704 VHL 7428 1 11 8
TCGA VHL 7428 6 64 26

Total number of gains: 29; Total number of losses: 219; Total Number of normals: 240.  

 

Somatic mutations of VHL:

 

Generating mutation plots.

 

Highly correlated genes for VHL:

 

Showing top 20/227 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
VHLGJD40.884068303
VHLMRPS160.853699303
VHLKLF170.846455303
VHLC9orf1530.834039303
VHLRBM430.814756303
VHLSTRC0.803787303
VHLDCDC10.803039303
VHLGRIK40.800587303
VHLYY20.793264303
VHLPLA2G2C0.791378303
VHLLBX20.790085303
VHLSLC22A310.788378303
VHLDSCAM-AS10.780314303
VHLOR2T270.772926303
VHLLDHAL6A0.760733303
VHLMRGPRG0.759482303
VHLTTC120.756127303
VHLTNFRSF140.755854303
VHLOR10AD10.754183303
VHLC1QL20.744628303

For details and further investigation, click here