| Full name: succinate-CoA ligase ADP-forming beta subunit | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 13q14.2 | ||
| Entrez ID: 8803 | HGNC ID: HGNC:11448 | Ensembl Gene: ENSG00000136143 | OMIM ID: 603921 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of SUCLA2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SUCLA2 | 8803 | 202930_s_at | -0.2079 | 0.7920 | |
| GSE20347 | SUCLA2 | 8803 | 202930_s_at | -0.6874 | 0.0012 | |
| GSE23400 | SUCLA2 | 8803 | 202930_s_at | -0.1903 | 0.0410 | |
| GSE26886 | SUCLA2 | 8803 | 202930_s_at | -1.0845 | 0.0007 | |
| GSE29001 | SUCLA2 | 8803 | 202930_s_at | -0.2525 | 0.5857 | |
| GSE38129 | SUCLA2 | 8803 | 202930_s_at | -0.6055 | 0.0000 | |
| GSE45670 | SUCLA2 | 8803 | 202930_s_at | -0.3235 | 0.0193 | |
| GSE53622 | SUCLA2 | 8803 | 47476 | -0.3009 | 0.0012 | |
| GSE53624 | SUCLA2 | 8803 | 47476 | -0.4590 | 0.0000 | |
| GSE63941 | SUCLA2 | 8803 | 202930_s_at | -0.5463 | 0.1733 | |
| GSE77861 | SUCLA2 | 8803 | 202930_s_at | -0.5354 | 0.0392 | |
| GSE97050 | SUCLA2 | 8803 | A_23_P117157 | -0.2798 | 0.2917 | |
| SRP007169 | SUCLA2 | 8803 | RNAseq | -0.9888 | 0.0104 | |
| SRP008496 | SUCLA2 | 8803 | RNAseq | -0.9449 | 0.0000 | |
| SRP064894 | SUCLA2 | 8803 | RNAseq | -0.4409 | 0.0479 | |
| SRP133303 | SUCLA2 | 8803 | RNAseq | -0.4149 | 0.0183 | |
| SRP159526 | SUCLA2 | 8803 | RNAseq | -0.7230 | 0.0086 | |
| SRP193095 | SUCLA2 | 8803 | RNAseq | -0.5674 | 0.0010 | |
| SRP219564 | SUCLA2 | 8803 | RNAseq | -0.7162 | 0.0494 | |
| TCGA | SUCLA2 | 8803 | RNAseq | -0.1428 | 0.0054 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by SUCLA2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SUCLA2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SUCLA2 | 8803 | 0 | 14 | 16 | |
| GSE20123 | SUCLA2 | 8803 | 0 | 13 | 17 | |
| GSE43470 | SUCLA2 | 8803 | 3 | 13 | 27 | |
| GSE46452 | SUCLA2 | 8803 | 0 | 32 | 27 | |
| GSE47630 | SUCLA2 | 8803 | 2 | 27 | 11 | |
| GSE54993 | SUCLA2 | 8803 | 12 | 2 | 56 | |
| GSE54994 | SUCLA2 | 8803 | 1 | 17 | 35 | |
| GSE60625 | SUCLA2 | 8803 | 0 | 3 | 8 | |
| GSE74703 | SUCLA2 | 8803 | 3 | 10 | 23 | |
| GSE74704 | SUCLA2 | 8803 | 0 | 10 | 10 | |
| TCGA | SUCLA2 | 8803 | 8 | 39 | 49 |
Total number of gains: 29; Total number of losses: 180; Total Number of normals: 279.
Somatic mutations of SUCLA2:
Generating mutation plots.
Highly correlated genes for SUCLA2:
Showing top 20/133 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SUCLA2 | CPEB2 | 0.705178 | 5 | 0 | 5 |
| SUCLA2 | SLC26A2 | 0.669962 | 3 | 0 | 3 |
| SUCLA2 | C4orf33 | 0.664139 | 3 | 0 | 3 |
| SUCLA2 | ZNF264 | 0.662693 | 3 | 0 | 3 |
| SUCLA2 | CENPC | 0.616015 | 4 | 0 | 3 |
| SUCLA2 | HACE1 | 0.612159 | 4 | 0 | 3 |
| SUCLA2 | CTTNBP2 | 0.611286 | 4 | 0 | 3 |
| SUCLA2 | SLC24A3 | 0.607728 | 6 | 0 | 5 |
| SUCLA2 | DENND2D | 0.601916 | 3 | 0 | 3 |
| SUCLA2 | GINM1 | 0.600675 | 3 | 0 | 3 |
| SUCLA2 | SARAF | 0.600022 | 6 | 0 | 3 |
| SUCLA2 | RTCA | 0.596688 | 7 | 0 | 6 |
| SUCLA2 | SNX16 | 0.596406 | 6 | 0 | 4 |
| SUCLA2 | FAAH2 | 0.595789 | 3 | 0 | 3 |
| SUCLA2 | SUMF1 | 0.59572 | 5 | 0 | 4 |
| SUCLA2 | DGAT2 | 0.592893 | 3 | 0 | 3 |
| SUCLA2 | GSKIP | 0.58888 | 5 | 0 | 5 |
| SUCLA2 | SPDYA | 0.58722 | 3 | 0 | 3 |
| SUCLA2 | LCORL | 0.585861 | 3 | 0 | 3 |
| SUCLA2 | PCCA | 0.585354 | 9 | 0 | 6 |
For details and further investigation, click here
