EFNA2

 

Full name: ephrin A2 Alias Symbol: ELF-1|LERK6
Type: protein-coding gene Cytoband: 19p13.3
Entrez ID: 1943 HGNC ID: HGNC:3222 Ensembl Gene: ENSG00000099617 OMIM ID: 602756
Drug and gene relationship at DGIdb

 

EFNA2 involved pathways:

KEGG pathway Description View
hsa04014Ras signaling pathway
hsa04015Rap1 signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04360Axon guidance

 

Expression of EFNA2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 EFNA2 1943 238956_at -0.6797 0.0330
GSE20347 EFNA2 1943 208256_at -0.0696 0.3111
GSE23400 EFNA2 1943 208256_at -0.0791 0.0026
GSE26886 EFNA2 1943 238956_at -0.3157 0.2822
GSE29001 EFNA2 1943 208256_at -0.1848 0.1763
GSE38129 EFNA2 1943 208256_at -0.1077 0.0608
GSE45670 EFNA2 1943 238956_at -0.0664 0.8530
GSE53622 EFNA2 1943 68736 -0.1929 0.0012
GSE53624 EFNA2 1943 68736 0.0963 0.0726
GSE63941 EFNA2 1943 238956_at 1.7824 0.0740
GSE77861 EFNA2 1943 208256_at -0.0978 0.3270
GSE97050 EFNA2 1943 A_23_P119535 0.1894 0.4509
SRP133303 EFNA2 1943 RNAseq 0.2572 0.3157
TCGA EFNA2 1943 RNAseq 0.7236 0.4481

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by EFNA2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of EFNA2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 EFNA2 1943 4 6 20
GSE20123 EFNA2 1943 4 5 21
GSE43470 EFNA2 1943 1 11 31
GSE46452 EFNA2 1943 47 1 11
GSE47630 EFNA2 1943 5 7 28
GSE54993 EFNA2 1943 13 4 53
GSE54994 EFNA2 1943 8 15 30
GSE60625 EFNA2 1943 9 0 2
GSE74703 EFNA2 1943 1 8 27
GSE74704 EFNA2 1943 3 3 14
TCGA EFNA2 1943 7 25 64

Total number of gains: 102; Total number of losses: 85; Total Number of normals: 301.  

 

Somatic mutations of EFNA2:

 

Generating mutation plots.

 

Highly correlated genes for EFNA2:

 

Showing top 20/700 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
EFNA2PRAMEF120.757866303
EFNA2CDHR50.725538606
EFNA2FRMPD10.714711303
EFNA2C20orf1730.712428303
EFNA2TNN0.709413303
EFNA2CNFN0.708976303
EFNA2ZNF503-AS10.70124303
EFNA2SYT30.700477303
EFNA2FAM81A0.697235303
EFNA2PRKCG0.69515403
EFNA2TMEM370.693925303
EFNA2DPF10.693492303
EFNA2ALDH1L10.693051303
EFNA2HS3ST40.691706303
EFNA2BRSK10.684527303
EFNA2KCNK90.67398403
EFNA2MYLPF0.673285605
EFNA2RNF390.672995303
EFNA2AMHR20.670218605
EFNA2GUCY2C0.666958303

For details and further investigation, click here