| Full name: sprouty RTK signaling antagonist 2 | Alias Symbol: hSPRY2 | ||
| Type: protein-coding gene | Cytoband: 13q31.1 | ||
| Entrez ID: 10253 | HGNC ID: HGNC:11270 | Ensembl Gene: ENSG00000136158 | OMIM ID: 602466 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of SPRY2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SPRY2 | 10253 | 204011_at | -1.1494 | 0.1471 | |
| GSE20347 | SPRY2 | 10253 | 204011_at | -0.4949 | 0.1421 | |
| GSE23400 | SPRY2 | 10253 | 204011_at | 0.0093 | 0.9516 | |
| GSE26886 | SPRY2 | 10253 | 204011_at | 1.1889 | 0.0149 | |
| GSE29001 | SPRY2 | 10253 | 204011_at | -0.1087 | 0.8880 | |
| GSE38129 | SPRY2 | 10253 | 204011_at | -0.5892 | 0.0625 | |
| GSE45670 | SPRY2 | 10253 | 204011_at | -1.1729 | 0.0048 | |
| GSE53622 | SPRY2 | 10253 | 140795 | -0.7678 | 0.0000 | |
| GSE53624 | SPRY2 | 10253 | 140795 | -0.5445 | 0.0002 | |
| GSE63941 | SPRY2 | 10253 | 204011_at | -1.2071 | 0.1957 | |
| GSE77861 | SPRY2 | 10253 | 204011_at | 0.4072 | 0.3488 | |
| GSE97050 | SPRY2 | 10253 | A_23_P128698 | -0.7353 | 0.1108 | |
| SRP007169 | SPRY2 | 10253 | RNAseq | 1.3879 | 0.0650 | |
| SRP008496 | SPRY2 | 10253 | RNAseq | 1.1615 | 0.0204 | |
| SRP064894 | SPRY2 | 10253 | RNAseq | -0.3339 | 0.2688 | |
| SRP133303 | SPRY2 | 10253 | RNAseq | -0.3228 | 0.4088 | |
| SRP159526 | SPRY2 | 10253 | RNAseq | -0.0335 | 0.9219 | |
| SRP193095 | SPRY2 | 10253 | RNAseq | -0.6252 | 0.0057 | |
| SRP219564 | SPRY2 | 10253 | RNAseq | -0.2934 | 0.6685 | |
| TCGA | SPRY2 | 10253 | RNAseq | -0.3559 | 0.0005 |
Upregulated datasets: 2; Downregulated datasets: 1.
Survival by SPRY2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SPRY2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SPRY2 | 10253 | 3 | 11 | 16 | |
| GSE20123 | SPRY2 | 10253 | 3 | 11 | 16 | |
| GSE43470 | SPRY2 | 10253 | 2 | 11 | 30 | |
| GSE46452 | SPRY2 | 10253 | 0 | 32 | 27 | |
| GSE47630 | SPRY2 | 10253 | 3 | 27 | 10 | |
| GSE54993 | SPRY2 | 10253 | 11 | 3 | 56 | |
| GSE54994 | SPRY2 | 10253 | 3 | 14 | 36 | |
| GSE60625 | SPRY2 | 10253 | 0 | 3 | 8 | |
| GSE74703 | SPRY2 | 10253 | 1 | 9 | 26 | |
| GSE74704 | SPRY2 | 10253 | 1 | 9 | 10 | |
| TCGA | SPRY2 | 10253 | 11 | 34 | 51 |
Total number of gains: 38; Total number of losses: 164; Total Number of normals: 286.
Somatic mutations of SPRY2:
Generating mutation plots.
Highly correlated genes for SPRY2:
Showing top 20/731 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SPRY2 | KCNE3 | 0.773618 | 3 | 0 | 3 |
| SPRY2 | EPC1 | 0.758874 | 3 | 0 | 3 |
| SPRY2 | ZNF862 | 0.747079 | 3 | 0 | 3 |
| SPRY2 | LONRF2 | 0.729339 | 4 | 0 | 3 |
| SPRY2 | XPC | 0.727655 | 3 | 0 | 3 |
| SPRY2 | LRFN5 | 0.715404 | 4 | 0 | 4 |
| SPRY2 | RHOJ | 0.71368 | 4 | 0 | 4 |
| SPRY2 | NR2F1 | 0.706433 | 3 | 0 | 3 |
| SPRY2 | DHRSX | 0.70555 | 3 | 0 | 3 |
| SPRY2 | EMILIN2 | 0.702719 | 3 | 0 | 3 |
| SPRY2 | TTC7B | 0.695349 | 3 | 0 | 3 |
| SPRY2 | FGF12 | 0.694235 | 4 | 0 | 4 |
| SPRY2 | GDPD1 | 0.693404 | 4 | 0 | 3 |
| SPRY2 | RBM7 | 0.692499 | 3 | 0 | 3 |
| SPRY2 | IFT46 | 0.68399 | 3 | 0 | 3 |
| SPRY2 | GPRASP2 | 0.682162 | 3 | 0 | 3 |
| SPRY2 | TCEAL6 | 0.678422 | 3 | 0 | 3 |
| SPRY2 | CRBN | 0.671944 | 4 | 0 | 3 |
| SPRY2 | MYOCD | 0.669044 | 5 | 0 | 4 |
| SPRY2 | AKIRIN1 | 0.668989 | 3 | 0 | 3 |
For details and further investigation, click here
