| Full name: enhancer of polycomb homolog 1 | Alias Symbol: Epl1 | ||
| Type: protein-coding gene | Cytoband: 10p11.22 | ||
| Entrez ID: 80314 | HGNC ID: HGNC:19876 | Ensembl Gene: ENSG00000120616 | OMIM ID: 610999 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of EPC1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | EPC1 | 80314 | 234969_s_at | -0.3552 | 0.4115 | |
| GSE26886 | EPC1 | 80314 | 234969_s_at | -0.9126 | 0.0005 | |
| GSE45670 | EPC1 | 80314 | 234969_s_at | -0.3033 | 0.0576 | |
| GSE53622 | EPC1 | 80314 | 7265 | -0.6051 | 0.0000 | |
| GSE53624 | EPC1 | 80314 | 7265 | -0.5093 | 0.0000 | |
| GSE63941 | EPC1 | 80314 | 234969_s_at | 0.2452 | 0.6187 | |
| GSE77861 | EPC1 | 80314 | 234969_s_at | -0.1838 | 0.2996 | |
| GSE97050 | EPC1 | 80314 | A_23_P46725 | -0.3384 | 0.1818 | |
| SRP007169 | EPC1 | 80314 | RNAseq | -0.0469 | 0.9017 | |
| SRP008496 | EPC1 | 80314 | RNAseq | -0.0524 | 0.8709 | |
| SRP064894 | EPC1 | 80314 | RNAseq | -0.2258 | 0.0851 | |
| SRP133303 | EPC1 | 80314 | RNAseq | -0.2954 | 0.0148 | |
| SRP159526 | EPC1 | 80314 | RNAseq | -0.4908 | 0.0372 | |
| SRP193095 | EPC1 | 80314 | RNAseq | -0.2941 | 0.0046 | |
| SRP219564 | EPC1 | 80314 | RNAseq | -0.3225 | 0.3830 | |
| TCGA | EPC1 | 80314 | RNAseq | -0.2066 | 0.0004 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by EPC1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of EPC1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | EPC1 | 80314 | 5 | 7 | 18 | |
| GSE20123 | EPC1 | 80314 | 5 | 6 | 19 | |
| GSE43470 | EPC1 | 80314 | 4 | 3 | 36 | |
| GSE46452 | EPC1 | 80314 | 1 | 14 | 44 | |
| GSE47630 | EPC1 | 80314 | 5 | 15 | 20 | |
| GSE54993 | EPC1 | 80314 | 9 | 0 | 61 | |
| GSE54994 | EPC1 | 80314 | 3 | 9 | 41 | |
| GSE60625 | EPC1 | 80314 | 0 | 0 | 11 | |
| GSE74703 | EPC1 | 80314 | 2 | 2 | 32 | |
| GSE74704 | EPC1 | 80314 | 0 | 5 | 15 | |
| TCGA | EPC1 | 80314 | 17 | 24 | 55 |
Total number of gains: 51; Total number of losses: 85; Total Number of normals: 352.
Somatic mutations of EPC1:
Generating mutation plots.
Highly correlated genes for EPC1:
Showing top 20/876 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| EPC1 | CCDC159 | 0.821932 | 3 | 0 | 3 |
| EPC1 | CNST | 0.79651 | 3 | 0 | 3 |
| EPC1 | HDHD2 | 0.764871 | 3 | 0 | 3 |
| EPC1 | ZDHHC17 | 0.762903 | 3 | 0 | 3 |
| EPC1 | CBLL1 | 0.762189 | 3 | 0 | 3 |
| EPC1 | SPRY2 | 0.758874 | 3 | 0 | 3 |
| EPC1 | TRIP11 | 0.752481 | 3 | 0 | 3 |
| EPC1 | OCRL | 0.746775 | 3 | 0 | 3 |
| EPC1 | HEATR5A | 0.746116 | 3 | 0 | 3 |
| EPC1 | NDST2 | 0.738446 | 3 | 0 | 3 |
| EPC1 | ZNF155 | 0.738053 | 3 | 0 | 3 |
| EPC1 | YTHDF2 | 0.731852 | 3 | 0 | 3 |
| EPC1 | ZNF225 | 0.731723 | 3 | 0 | 3 |
| EPC1 | C5orf51 | 0.728656 | 3 | 0 | 3 |
| EPC1 | SF3A1 | 0.728155 | 3 | 0 | 3 |
| EPC1 | ZFAND5 | 0.724587 | 4 | 0 | 3 |
| EPC1 | TBRG1 | 0.723224 | 3 | 0 | 3 |
| EPC1 | UQCR11 | 0.719126 | 3 | 0 | 3 |
| EPC1 | LETMD1 | 0.71775 | 4 | 0 | 4 |
| EPC1 | DMAP1 | 0.712684 | 3 | 0 | 3 |
For details and further investigation, click here
