| Full name: XPC complex subunit, DNA damage recognition and repair factor | Alias Symbol: XPCC|RAD4 | ||
| Type: protein-coding gene | Cytoband: 3p25.1 | ||
| Entrez ID: 7508 | HGNC ID: HGNC:12816 | Ensembl Gene: ENSG00000154767 | OMIM ID: 613208 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of XPC:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | XPC | 7508 | 209375_at | -0.7151 | 0.0207 | |
| GSE20347 | XPC | 7508 | 209375_at | -0.4240 | 0.0034 | |
| GSE23400 | XPC | 7508 | 209375_at | -0.1635 | 0.0006 | |
| GSE26886 | XPC | 7508 | 209375_at | 0.0421 | 0.8405 | |
| GSE29001 | XPC | 7508 | 209375_at | -0.5551 | 0.0006 | |
| GSE38129 | XPC | 7508 | 209375_at | -0.5197 | 0.0000 | |
| GSE45670 | XPC | 7508 | 209375_at | -0.6913 | 0.0000 | |
| GSE63941 | XPC | 7508 | 209375_at | -0.8146 | 0.0680 | |
| GSE77861 | XPC | 7508 | 209375_at | -0.2279 | 0.3088 | |
| GSE97050 | XPC | 7508 | A_24_P88921 | -0.0927 | 0.7160 | |
| SRP007169 | XPC | 7508 | RNAseq | 0.7528 | 0.2589 | |
| SRP064894 | XPC | 7508 | RNAseq | -0.3508 | 0.0644 | |
| SRP133303 | XPC | 7508 | RNAseq | -0.8402 | 0.0000 | |
| SRP159526 | XPC | 7508 | RNAseq | -0.7288 | 0.0005 | |
| SRP193095 | XPC | 7508 | RNAseq | -0.4247 | 0.0000 | |
| SRP219564 | XPC | 7508 | RNAseq | -0.4221 | 0.1770 | |
| TCGA | XPC | 7508 | RNAseq | -0.2439 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by XPC expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of XPC:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | XPC | 7508 | 2 | 18 | 10 | |
| GSE20123 | XPC | 7508 | 2 | 18 | 10 | |
| GSE43470 | XPC | 7508 | 0 | 21 | 22 | |
| GSE46452 | XPC | 7508 | 2 | 17 | 40 | |
| GSE47630 | XPC | 7508 | 2 | 23 | 15 | |
| GSE54993 | XPC | 7508 | 6 | 1 | 63 | |
| GSE54994 | XPC | 7508 | 1 | 32 | 20 | |
| GSE60625 | XPC | 7508 | 5 | 0 | 6 | |
| GSE74703 | XPC | 7508 | 0 | 17 | 19 | |
| GSE74704 | XPC | 7508 | 1 | 11 | 8 | |
| TCGA | XPC | 7508 | 2 | 68 | 26 |
Total number of gains: 23; Total number of losses: 226; Total Number of normals: 239.
Somatic mutations of XPC:
Generating mutation plots.
Highly correlated genes for XPC:
Showing top 20/914 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| XPC | DOCK8 | 0.825204 | 3 | 0 | 3 |
| XPC | KCTD6 | 0.784382 | 3 | 0 | 3 |
| XPC | SMTNL2 | 0.77366 | 3 | 0 | 3 |
| XPC | IGBP1 | 0.7667 | 3 | 0 | 3 |
| XPC | KCNT2 | 0.765798 | 3 | 0 | 3 |
| XPC | ZNF441 | 0.759741 | 3 | 0 | 3 |
| XPC | ZNF44 | 0.758986 | 3 | 0 | 3 |
| XPC | CLU | 0.758503 | 3 | 0 | 3 |
| XPC | COMMD6 | 0.74872 | 3 | 0 | 3 |
| XPC | FRMD3 | 0.747962 | 3 | 0 | 3 |
| XPC | WWTR1 | 0.747476 | 3 | 0 | 3 |
| XPC | RNPC3 | 0.746571 | 3 | 0 | 3 |
| XPC | ST6GALNAC6 | 0.746532 | 4 | 0 | 4 |
| XPC | CHID1 | 0.744395 | 3 | 0 | 3 |
| XPC | FGD5-AS1 | 0.743952 | 3 | 0 | 3 |
| XPC | CGGBP1 | 0.743424 | 4 | 0 | 4 |
| XPC | C1QTNF7 | 0.742276 | 3 | 0 | 3 |
| XPC | RBM20 | 0.741254 | 3 | 0 | 3 |
| XPC | SETD4 | 0.741038 | 3 | 0 | 3 |
| XPC | PNISR | 0.740005 | 3 | 0 | 3 |
For details and further investigation, click here
