| Full name: splA/ryanodine receptor domain and SOCS box containing 1 | Alias Symbol: SSB-1 | ||
| Type: protein-coding gene | Cytoband: 1p36.22 | ||
| Entrez ID: 80176 | HGNC ID: HGNC:30628 | Ensembl Gene: ENSG00000171621 | OMIM ID: 611657 |
| Drug and gene relationship at DGIdb | |||
Expression of SPSB1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SPSB1 | 80176 | 226075_at | 0.7748 | 0.2749 | |
| GSE20347 | SPSB1 | 80176 | 219677_at | 0.1826 | 0.2864 | |
| GSE23400 | SPSB1 | 80176 | 219677_at | 0.2925 | 0.0000 | |
| GSE26886 | SPSB1 | 80176 | 219677_at | 1.3542 | 0.0000 | |
| GSE29001 | SPSB1 | 80176 | 219677_at | 0.1953 | 0.6104 | |
| GSE38129 | SPSB1 | 80176 | 219677_at | 0.2569 | 0.1346 | |
| GSE45670 | SPSB1 | 80176 | 219677_at | 0.4337 | 0.0154 | |
| GSE53622 | SPSB1 | 80176 | 43357 | 0.6631 | 0.0000 | |
| GSE53624 | SPSB1 | 80176 | 43357 | 0.5766 | 0.0000 | |
| GSE63941 | SPSB1 | 80176 | 219677_at | -0.2588 | 0.7053 | |
| GSE77861 | SPSB1 | 80176 | 226075_at | 0.3671 | 0.2612 | |
| GSE97050 | SPSB1 | 80176 | A_23_P200096 | 0.1042 | 0.7015 | |
| SRP007169 | SPSB1 | 80176 | RNAseq | -0.1330 | 0.7461 | |
| SRP008496 | SPSB1 | 80176 | RNAseq | 0.1871 | 0.5180 | |
| SRP064894 | SPSB1 | 80176 | RNAseq | -0.0407 | 0.8579 | |
| SRP133303 | SPSB1 | 80176 | RNAseq | 0.7252 | 0.0067 | |
| SRP159526 | SPSB1 | 80176 | RNAseq | 0.6360 | 0.0121 | |
| SRP193095 | SPSB1 | 80176 | RNAseq | 0.6171 | 0.0060 | |
| SRP219564 | SPSB1 | 80176 | RNAseq | 0.4323 | 0.3727 | |
| TCGA | SPSB1 | 80176 | RNAseq | 0.1789 | 0.0083 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by SPSB1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SPSB1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SPSB1 | 80176 | 1 | 5 | 24 | |
| GSE20123 | SPSB1 | 80176 | 1 | 3 | 26 | |
| GSE43470 | SPSB1 | 80176 | 6 | 5 | 32 | |
| GSE46452 | SPSB1 | 80176 | 7 | 1 | 51 | |
| GSE47630 | SPSB1 | 80176 | 8 | 4 | 28 | |
| GSE54993 | SPSB1 | 80176 | 3 | 2 | 65 | |
| GSE54994 | SPSB1 | 80176 | 12 | 4 | 37 | |
| GSE60625 | SPSB1 | 80176 | 0 | 0 | 11 | |
| GSE74703 | SPSB1 | 80176 | 5 | 3 | 28 | |
| GSE74704 | SPSB1 | 80176 | 1 | 0 | 19 | |
| TCGA | SPSB1 | 80176 | 10 | 24 | 62 |
Total number of gains: 54; Total number of losses: 51; Total Number of normals: 383.
Somatic mutations of SPSB1:
Generating mutation plots.
Highly correlated genes for SPSB1:
Showing top 20/624 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SPSB1 | HDAC7 | 0.770473 | 3 | 0 | 3 |
| SPSB1 | ZNF574 | 0.752276 | 3 | 0 | 3 |
| SPSB1 | ARHGEF2 | 0.740028 | 3 | 0 | 3 |
| SPSB1 | SSBP4 | 0.7387 | 4 | 0 | 4 |
| SPSB1 | ANKRD27 | 0.727887 | 3 | 0 | 3 |
| SPSB1 | PPP1R16A | 0.714485 | 3 | 0 | 3 |
| SPSB1 | EGFL7 | 0.710873 | 3 | 0 | 3 |
| SPSB1 | DEXI | 0.710059 | 3 | 0 | 3 |
| SPSB1 | ZFYVE27 | 0.707281 | 3 | 0 | 3 |
| SPSB1 | ZNF18 | 0.707132 | 3 | 0 | 3 |
| SPSB1 | ZNF628 | 0.703278 | 4 | 0 | 4 |
| SPSB1 | CHIC1 | 0.70192 | 3 | 0 | 3 |
| SPSB1 | C11orf68 | 0.700002 | 3 | 0 | 3 |
| SPSB1 | POGLUT1 | 0.69841 | 3 | 0 | 3 |
| SPSB1 | SLC26A11 | 0.69656 | 3 | 0 | 3 |
| SPSB1 | ANKRD23 | 0.696077 | 3 | 0 | 3 |
| SPSB1 | SLC25A29 | 0.689977 | 3 | 0 | 3 |
| SPSB1 | CENPV | 0.687524 | 3 | 0 | 3 |
| SPSB1 | DHRSX | 0.686449 | 3 | 0 | 3 |
| SPSB1 | CSNK1G2 | 0.686151 | 3 | 0 | 3 |
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