| Full name: splA/ryanodine receptor domain and SOCS box containing 3 | Alias Symbol: SSB-3 | ||
| Type: protein-coding gene | Cytoband: 16p13.3 | ||
| Entrez ID: 90864 | HGNC ID: HGNC:30629 | Ensembl Gene: ENSG00000162032 | OMIM ID: 611659 |
| Drug and gene relationship at DGIdb | |||
Expression of SPSB3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SPSB3 | 90864 | 46256_at | -0.3330 | 0.4713 | |
| GSE20347 | SPSB3 | 90864 | 46256_at | -0.5633 | 0.0000 | |
| GSE23400 | SPSB3 | 90864 | 46256_at | -0.4196 | 0.0000 | |
| GSE26886 | SPSB3 | 90864 | 46256_at | -0.5930 | 0.0107 | |
| GSE29001 | SPSB3 | 90864 | 46256_at | -0.5442 | 0.0542 | |
| GSE38129 | SPSB3 | 90864 | 46256_at | -0.6021 | 0.0000 | |
| GSE45670 | SPSB3 | 90864 | 46256_at | -0.6629 | 0.0011 | |
| GSE53622 | SPSB3 | 90864 | 33012 | -0.8216 | 0.0000 | |
| GSE53624 | SPSB3 | 90864 | 33012 | -0.7566 | 0.0000 | |
| GSE63941 | SPSB3 | 90864 | 46256_at | 0.3141 | 0.2400 | |
| GSE77861 | SPSB3 | 90864 | 46256_at | -0.6063 | 0.0049 | |
| GSE97050 | SPSB3 | 90864 | A_33_P3235716 | -0.5512 | 0.1811 | |
| SRP007169 | SPSB3 | 90864 | RNAseq | -3.5358 | 0.0000 | |
| SRP008496 | SPSB3 | 90864 | RNAseq | -3.3505 | 0.0000 | |
| SRP064894 | SPSB3 | 90864 | RNAseq | -0.9745 | 0.0008 | |
| SRP133303 | SPSB3 | 90864 | RNAseq | -0.8826 | 0.0000 | |
| SRP159526 | SPSB3 | 90864 | RNAseq | -1.0312 | 0.0000 | |
| SRP193095 | SPSB3 | 90864 | RNAseq | -0.8113 | 0.0000 | |
| SRP219564 | SPSB3 | 90864 | RNAseq | -0.6673 | 0.1783 | |
| TCGA | SPSB3 | 90864 | RNAseq | -0.0827 | 0.1116 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by SPSB3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SPSB3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SPSB3 | 90864 | 5 | 5 | 20 | |
| GSE20123 | SPSB3 | 90864 | 5 | 4 | 21 | |
| GSE43470 | SPSB3 | 90864 | 4 | 7 | 32 | |
| GSE46452 | SPSB3 | 90864 | 38 | 1 | 20 | |
| GSE47630 | SPSB3 | 90864 | 13 | 6 | 21 | |
| GSE54993 | SPSB3 | 90864 | 3 | 5 | 62 | |
| GSE54994 | SPSB3 | 90864 | 6 | 8 | 39 | |
| GSE60625 | SPSB3 | 90864 | 4 | 0 | 7 | |
| GSE74703 | SPSB3 | 90864 | 4 | 5 | 27 | |
| GSE74704 | SPSB3 | 90864 | 3 | 2 | 15 | |
| TCGA | SPSB3 | 90864 | 19 | 14 | 63 |
Total number of gains: 104; Total number of losses: 57; Total Number of normals: 327.
Somatic mutations of SPSB3:
Generating mutation plots.
Highly correlated genes for SPSB3:
Showing top 20/936 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SPSB3 | C5orf66-AS1 | 0.791487 | 6 | 0 | 6 |
| SPSB3 | MIEF2 | 0.773542 | 6 | 0 | 6 |
| SPSB3 | FAM163B | 0.76635 | 3 | 0 | 3 |
| SPSB3 | ARHGEF10L | 0.76534 | 10 | 0 | 10 |
| SPSB3 | TAX1BP1 | 0.765137 | 8 | 0 | 8 |
| SPSB3 | MUC22 | 0.755755 | 3 | 0 | 3 |
| SPSB3 | SASH1 | 0.75543 | 10 | 0 | 10 |
| SPSB3 | SNORA68 | 0.752386 | 4 | 0 | 4 |
| SPSB3 | FAM214A | 0.751993 | 6 | 0 | 6 |
| SPSB3 | FAM221A | 0.742903 | 6 | 0 | 6 |
| SPSB3 | NCCRP1 | 0.73724 | 3 | 0 | 3 |
| SPSB3 | SH3BGRL2 | 0.727307 | 6 | 0 | 6 |
| SPSB3 | SMIM5 | 0.726859 | 6 | 0 | 6 |
| SPSB3 | TTC9 | 0.72322 | 10 | 0 | 10 |
| SPSB3 | SLC37A1 | 0.722407 | 11 | 0 | 10 |
| SPSB3 | MXD1 | 0.721437 | 10 | 0 | 10 |
| SPSB3 | MFSD2B | 0.720871 | 3 | 0 | 3 |
| SPSB3 | ANKRD13A | 0.717918 | 5 | 0 | 5 |
| SPSB3 | ANXA9 | 0.717792 | 10 | 0 | 9 |
| SPSB3 | HEBP2 | 0.717585 | 9 | 0 | 9 |
For details and further investigation, click here
