| Full name: tetratricopeptide repeat domain 9 | Alias Symbol: KIAA0227|TTC9A | ||
| Type: protein-coding gene | Cytoband: 14q24.2 | ||
| Entrez ID: 23508 | HGNC ID: HGNC:20267 | Ensembl Gene: ENSG00000133985 | OMIM ID: 610488 |
| Drug and gene relationship at DGIdb | |||
Expression of TTC9:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TTC9 | 23508 | 213174_at | -1.6246 | 0.1352 | |
| GSE20347 | TTC9 | 23508 | 213174_at | -2.5305 | 0.0000 | |
| GSE23400 | TTC9 | 23508 | 213174_at | -2.1232 | 0.0000 | |
| GSE26886 | TTC9 | 23508 | 213174_at | -3.2969 | 0.0000 | |
| GSE29001 | TTC9 | 23508 | 213172_at | -2.9180 | 0.0001 | |
| GSE38129 | TTC9 | 23508 | 213174_at | -2.1166 | 0.0000 | |
| GSE45670 | TTC9 | 23508 | 213174_at | -1.2967 | 0.0012 | |
| GSE53622 | TTC9 | 23508 | 80314 | -2.3176 | 0.0000 | |
| GSE53624 | TTC9 | 23508 | 80314 | -3.2718 | 0.0000 | |
| GSE63941 | TTC9 | 23508 | 213174_at | 0.4407 | 0.6218 | |
| GSE77861 | TTC9 | 23508 | 213174_at | -1.7742 | 0.0007 | |
| GSE97050 | TTC9 | 23508 | A_24_P273742 | -0.3945 | 0.2144 | |
| SRP007169 | TTC9 | 23508 | RNAseq | -4.0373 | 0.0000 | |
| SRP008496 | TTC9 | 23508 | RNAseq | -4.0402 | 0.0000 | |
| SRP064894 | TTC9 | 23508 | RNAseq | -4.3128 | 0.0000 | |
| SRP133303 | TTC9 | 23508 | RNAseq | -2.8272 | 0.0000 | |
| SRP159526 | TTC9 | 23508 | RNAseq | -3.9693 | 0.0000 | |
| SRP193095 | TTC9 | 23508 | RNAseq | -3.4797 | 0.0000 | |
| SRP219564 | TTC9 | 23508 | RNAseq | -4.2969 | 0.0000 | |
| TCGA | TTC9 | 23508 | RNAseq | -0.1292 | 0.4616 |
Upregulated datasets: 0; Downregulated datasets: 16.
Survival by TTC9 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TTC9:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TTC9 | 23508 | 8 | 3 | 19 | |
| GSE20123 | TTC9 | 23508 | 8 | 3 | 19 | |
| GSE43470 | TTC9 | 23508 | 8 | 3 | 32 | |
| GSE46452 | TTC9 | 23508 | 16 | 3 | 40 | |
| GSE47630 | TTC9 | 23508 | 11 | 9 | 20 | |
| GSE54993 | TTC9 | 23508 | 3 | 9 | 58 | |
| GSE54994 | TTC9 | 23508 | 18 | 5 | 30 | |
| GSE60625 | TTC9 | 23508 | 0 | 2 | 9 | |
| GSE74703 | TTC9 | 23508 | 7 | 3 | 26 | |
| GSE74704 | TTC9 | 23508 | 3 | 3 | 14 | |
| TCGA | TTC9 | 23508 | 32 | 16 | 48 |
Total number of gains: 114; Total number of losses: 59; Total Number of normals: 315.
Somatic mutations of TTC9:
Generating mutation plots.
Highly correlated genes for TTC9:
Showing top 20/1867 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TTC9 | CLIC3 | 0.882481 | 9 | 0 | 9 |
| TTC9 | GBP6 | 0.879842 | 4 | 0 | 4 |
| TTC9 | C5orf66-AS1 | 0.873751 | 6 | 0 | 6 |
| TTC9 | GYS2 | 0.873359 | 10 | 0 | 10 |
| TTC9 | EPS8L1 | 0.870982 | 12 | 0 | 12 |
| TTC9 | RANBP9 | 0.868466 | 11 | 0 | 11 |
| TTC9 | EHD3 | 0.86331 | 11 | 0 | 11 |
| TTC9 | ATG9B | 0.860532 | 7 | 0 | 7 |
| TTC9 | ARHGAP27 | 0.858467 | 7 | 0 | 7 |
| TTC9 | SPINK7 | 0.855793 | 6 | 0 | 6 |
| TTC9 | SNORA68 | 0.855754 | 4 | 0 | 4 |
| TTC9 | BLNK | 0.855126 | 11 | 0 | 11 |
| TTC9 | C18orf25 | 0.854383 | 11 | 0 | 11 |
| TTC9 | EVPL | 0.854247 | 11 | 0 | 11 |
| TTC9 | FUT3 | 0.853353 | 13 | 0 | 12 |
| TTC9 | CRISP3 | 0.852668 | 11 | 0 | 11 |
| TTC9 | ANXA9 | 0.852148 | 12 | 0 | 12 |
| TTC9 | SLC16A6 | 0.851886 | 11 | 0 | 11 |
| TTC9 | SLURP1 | 0.851313 | 11 | 0 | 11 |
| TTC9 | ESPL1 | 0.851137 | 10 | 0 | 10 |
For details and further investigation, click here
