TAX1BP1

 

Full name: Tax1 binding protein 1 Alias Symbol: TXBP151|CALCOCO3
Type: protein-coding gene Cytoband: 7p15.2
Entrez ID: 8887 HGNC ID: HGNC:11575 Ensembl Gene: ENSG00000106052 OMIM ID: 605326
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of TAX1BP1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 TAX1BP1 8887 200977_s_at -0.7539 0.1188
GSE20347 TAX1BP1 8887 200977_s_at -1.1280 0.0000
GSE23400 TAX1BP1 8887 200976_s_at -0.8208 0.0000
GSE26886 TAX1BP1 8887 200977_s_at -0.6031 0.0159
GSE29001 TAX1BP1 8887 200977_s_at -0.9931 0.0109
GSE38129 TAX1BP1 8887 200976_s_at -0.7366 0.0000
GSE45670 TAX1BP1 8887 200977_s_at -0.8210 0.0002
GSE53622 TAX1BP1 8887 80565 -0.9007 0.0000
GSE53624 TAX1BP1 8887 80565 -1.0443 0.0000
GSE63941 TAX1BP1 8887 200977_s_at 0.2085 0.6453
GSE77861 TAX1BP1 8887 200977_s_at -0.9798 0.0098
GSE97050 TAX1BP1 8887 A_24_P95029 -0.9954 0.0950
SRP007169 TAX1BP1 8887 RNAseq -2.8307 0.0000
SRP008496 TAX1BP1 8887 RNAseq -2.4229 0.0000
SRP064894 TAX1BP1 8887 RNAseq -1.7127 0.0000
SRP133303 TAX1BP1 8887 RNAseq -0.9200 0.0000
SRP159526 TAX1BP1 8887 RNAseq -1.1975 0.0000
SRP193095 TAX1BP1 8887 RNAseq -1.5834 0.0000
SRP219564 TAX1BP1 8887 RNAseq -1.5165 0.0027
TCGA TAX1BP1 8887 RNAseq -0.1227 0.0165

Upregulated datasets: 0; Downregulated datasets: 8.  

 

Survival by TAX1BP1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of TAX1BP1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 TAX1BP1 8887 16 1 13
GSE20123 TAX1BP1 8887 16 1 13
GSE43470 TAX1BP1 8887 4 0 39
GSE46452 TAX1BP1 8887 10 2 47
GSE47630 TAX1BP1 8887 8 1 31
GSE54993 TAX1BP1 8887 0 6 64
GSE54994 TAX1BP1 8887 20 2 31
GSE60625 TAX1BP1 8887 0 0 11
GSE74703 TAX1BP1 8887 4 0 32
GSE74704 TAX1BP1 8887 10 1 9
TCGA TAX1BP1 8887 53 9 34

Total number of gains: 141; Total number of losses: 23; Total Number of normals: 324.  

 

Somatic mutations of TAX1BP1:

 

Generating mutation plots.

 

Highly correlated genes for TAX1BP1:

 

Showing top 20/1472 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
TAX1BP1NUCB20.81286511011
TAX1BP1GYS20.79849910010
TAX1BP1STRADB0.790988707
TAX1BP1YOD10.78167111011
TAX1BP1EHD30.77259111011
TAX1BP1HPGD0.76694110010
TAX1BP1CAST0.76579611011
TAX1BP1TRIP100.76514411010
TAX1BP1SPSB30.765137808
TAX1BP1ABLIM30.76412710010
TAX1BP1SASH10.76308211011
TAX1BP1RANBP90.76153212011
TAX1BP1C18orf250.75964311011
TAX1BP1ECM10.75924611010
TAX1BP1SORT10.75890610010
TAX1BP1UBL30.75788611010
TAX1BP1AIF1L0.756688606
TAX1BP1ABHD50.75639912011
TAX1BP1CA130.756345303
TAX1BP1EMC30.75584810010

For details and further investigation, click here