| Full name: Rho guanine nucleotide exchange factor 10 like | Alias Symbol: FLJ10521|KIAA1626 | ||
| Type: protein-coding gene | Cytoband: 1p36.13 | ||
| Entrez ID: 55160 | HGNC ID: HGNC:25540 | Ensembl Gene: ENSG00000074964 | OMIM ID: 612494 |
| Drug and gene relationship at DGIdb | |||
Expression of ARHGEF10L:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ARHGEF10L | 55160 | 221656_s_at | -0.8906 | 0.0401 | |
| GSE20347 | ARHGEF10L | 55160 | 221656_s_at | -1.5588 | 0.0000 | |
| GSE23400 | ARHGEF10L | 55160 | 221656_s_at | -0.9608 | 0.0000 | |
| GSE26886 | ARHGEF10L | 55160 | 221656_s_at | -1.0282 | 0.0002 | |
| GSE29001 | ARHGEF10L | 55160 | 221656_s_at | -1.0836 | 0.0005 | |
| GSE38129 | ARHGEF10L | 55160 | 221656_s_at | -1.2985 | 0.0000 | |
| GSE45670 | ARHGEF10L | 55160 | 221656_s_at | -0.6691 | 0.0038 | |
| GSE53622 | ARHGEF10L | 55160 | 92658 | -1.8494 | 0.0000 | |
| GSE53624 | ARHGEF10L | 55160 | 92658 | -1.9798 | 0.0000 | |
| GSE63941 | ARHGEF10L | 55160 | 221656_s_at | -0.3732 | 0.2934 | |
| GSE77861 | ARHGEF10L | 55160 | 221656_s_at | -1.0476 | 0.0007 | |
| GSE97050 | ARHGEF10L | 55160 | A_33_P3799936 | -0.8470 | 0.0828 | |
| SRP007169 | ARHGEF10L | 55160 | RNAseq | -3.5067 | 0.0000 | |
| SRP008496 | ARHGEF10L | 55160 | RNAseq | -3.1764 | 0.0000 | |
| SRP064894 | ARHGEF10L | 55160 | RNAseq | -1.4453 | 0.0000 | |
| SRP133303 | ARHGEF10L | 55160 | RNAseq | -1.6950 | 0.0000 | |
| SRP159526 | ARHGEF10L | 55160 | RNAseq | -1.7242 | 0.0000 | |
| SRP193095 | ARHGEF10L | 55160 | RNAseq | -1.2018 | 0.0000 | |
| SRP219564 | ARHGEF10L | 55160 | RNAseq | -1.1964 | 0.0062 | |
| TCGA | ARHGEF10L | 55160 | RNAseq | -0.3720 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 14.
Survival by ARHGEF10L expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ARHGEF10L:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ARHGEF10L | 55160 | 0 | 5 | 25 | |
| GSE20123 | ARHGEF10L | 55160 | 0 | 4 | 26 | |
| GSE43470 | ARHGEF10L | 55160 | 0 | 8 | 35 | |
| GSE46452 | ARHGEF10L | 55160 | 5 | 1 | 53 | |
| GSE47630 | ARHGEF10L | 55160 | 8 | 3 | 29 | |
| GSE54993 | ARHGEF10L | 55160 | 3 | 1 | 66 | |
| GSE54994 | ARHGEF10L | 55160 | 10 | 4 | 39 | |
| GSE60625 | ARHGEF10L | 55160 | 0 | 0 | 11 | |
| GSE74703 | ARHGEF10L | 55160 | 0 | 5 | 31 | |
| GSE74704 | ARHGEF10L | 55160 | 0 | 0 | 20 | |
| TCGA | ARHGEF10L | 55160 | 10 | 23 | 63 |
Total number of gains: 36; Total number of losses: 54; Total Number of normals: 398.
Somatic mutations of ARHGEF10L:
Generating mutation plots.
Highly correlated genes for ARHGEF10L:
Showing top 20/1819 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ARHGEF10L | EPS8L1 | 0.858659 | 10 | 0 | 10 |
| ARHGEF10L | SMIM5 | 0.851201 | 6 | 0 | 6 |
| ARHGEF10L | TRIP10 | 0.848177 | 11 | 0 | 11 |
| ARHGEF10L | SNORA68 | 0.847954 | 4 | 0 | 4 |
| ARHGEF10L | C5orf66-AS1 | 0.843916 | 6 | 0 | 6 |
| ARHGEF10L | HPGD | 0.843777 | 11 | 0 | 11 |
| ARHGEF10L | CPEB3 | 0.835411 | 10 | 0 | 10 |
| ARHGEF10L | CGNL1 | 0.833699 | 7 | 0 | 7 |
| ARHGEF10L | SASH1 | 0.831299 | 12 | 0 | 12 |
| ARHGEF10L | KAT2B | 0.8272 | 11 | 0 | 10 |
| ARHGEF10L | PADI1 | 0.827049 | 8 | 0 | 8 |
| ARHGEF10L | FAM95B1 | 0.826518 | 4 | 0 | 4 |
| ARHGEF10L | SORT1 | 0.823594 | 11 | 0 | 11 |
| ARHGEF10L | MAL | 0.821947 | 10 | 0 | 10 |
| ARHGEF10L | FCHO2 | 0.819872 | 7 | 0 | 7 |
| ARHGEF10L | SIM2 | 0.819327 | 11 | 0 | 11 |
| ARHGEF10L | PRSS27 | 0.81908 | 6 | 0 | 6 |
| ARHGEF10L | SLURP1 | 0.817052 | 10 | 0 | 10 |
| ARHGEF10L | VPS13D | 0.81593 | 11 | 0 | 11 |
| ARHGEF10L | SCNN1B | 0.814689 | 11 | 0 | 10 |
For details and further investigation, click here
